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Pregnancy-Associated Plasma Protein A, Pappalysin 1 Proteins (PAPPA)

PAPPA encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Additionally we are shipping PAPPA Antibodies (415) and PAPPA Kits (47) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PAPPA 18491 Q8R4K8
Rat PAPPA PAPPA 313262  
PAPPA 5069 Q13219
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Top PAPPA Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
$11,073.30
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
$11,073.30
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$679.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
$753.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Human Human Un-conjugated   100 μg Log in to see 9 to 11 Days
$904.93
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$5,329.50
Details
HOST_Human Human Un-conjugated   100 mIU Log in to see 11 to 13 Days
$476.02
Details
HOST_Human Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$735.00
Details

PAPPA Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , , ,
,

More Proteins for Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) Interaction Partners

Mouse (Murine) Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) interaction partners

  1. STC2 (show STC2 Proteins) is involved in regulating PAPP-A activity during the development of atherosclerosis

  2. Study demonstrates proof-of-principle and provides feasibility for a novel therapeutic strategy to inhibit atherosclerotic plaque burden by selective targeting of PAPP-A.

  3. stimulation of PAPP-A expression by intermittent PTH (show PTH Proteins) treatment contributes to PTH (show PTH Proteins) bone anabolism in mice

  4. PAPP-A affects fascicle structure, thereby affecting tendon phenotype.

  5. PAPP-A has a role in development of advanced plaque with necrotic cores and buried fibrous caps (show CAPS Proteins) in the brachiocephalic artery

  6. these data indicate preferential impact of PAPP-A deficiency on visceral fat in the mouse that is associated with enhanced insulin receptor (show INSR Proteins) signaling

  7. Studies show a conditional PAPP-A knockout (KO) model for efficacy of tamoxifen-induced floxed PAPP-A excision in various tissues and indicate a significant reduction of neointimal formation after unilateral carotid artery ligation.

  8. absence of PAPP-A is associated with resistance to the development of indicators of diabetic nephropathy in mice

  9. Pregnancy-associated plasma protein (PAPP)-A expressed in the mammary gland controls epithelial cell proliferation and differentiation.

  10. Data conclude that PAPP-A proteolytic activity is required for the lesion-promoting effect of PAPP-A and that its specificity must be directed against IGFBP-4 (show IGFBP4 Proteins).

Human Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) interaction partners

  1. This study demonstrated no association between PAPP-A gene rs7020782 polymorphism and Preeclampsia (PE) and intrauterine growth restriction.

  2. data indicate that PAPP-A promotes TF expression in human endothelial cells and support the hypothesis that this proteinase, besides being involved in progression of atherosclerosis, does not represent an independent risk factor for adverse cardiovascular events, but it rather might play an "active" role in the pathophysiology of ACS as an effector molecule able to induce a pro-thrombotic phenotype in endothelial cells

  3. assessed serum PAPP-A levels in COPD (show ARCN1 Proteins) and the associations with disease severity; elevated levels of PAPP-A were observed in patients with COPD (show ARCN1 Proteins)

  4. STC2 (show STC2 Proteins) is involved in regulating PAPP-A activity during the development of atherosclerosis

  5. Data suggest that stanniocalcin 1 (show STC1 Proteins) and 2 (STC1 (show STC1 Proteins), STC2 (show STC2 Proteins)) participate in inhibition of proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A) during folliculogenesis.

  6. measurements of maternal serum PAPP-A concentration in the first trimester predict severe fetal growth restriction more effectively than they predict a birth weight below the 10th percentile among a Chinese population

  7. Women with PAPP-A PAPP-A >/=90th percentile is protective against small for gestational age, and is associated with an increased risk of large for gestational age for infants born after 32 weeks gestation.

  8. Data suggest that incidences of intrauterine growth restriction, pre-eclampsia, preterm birth, and fetal death are significantly greater in pregnant women with low serum levels of PAPP-A in first trimester (9-13 weeks of pregnancy) as compared to control pregnant women; study was conducted in India.

  9. The first trimester maternal PAPP-A levels were decreased in the ICSI group compared with those in the controls, but not in IVF (show SCN5A Proteins) and embryo transfer groups.

  10. miR (show MLXIP Proteins)-141 may play important roles in ox-LDL-induced abnormal proliferation of the vascular smooth muscle cells by targeting PAPPA.

Cow (Bovine) Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) interaction partners

  1. study determined IGFR1 (show IGF1R Proteins) and PAPP-A expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD (show SNRPB Proteins)) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 (show IGF1R Proteins) expression and PAPP-A secretion as a modulator of IGF1 (show IGF1 Proteins) in cattle with COD (show SNRPB Proteins)

  2. in preovulatory follicles, PAPP-A is responsible for IGF-dependent IGFBP-2 degradation

  3. concluded that changes in granulosa cell PAPP-A mRNA levels do not occur during final preovulatory follicular development in cattle

PAPPA Protein Profile

Protein Summary

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses.

Gene names and symbols associated with PAPPA

  • pregnancy-associated plasma protein-A (PAPP-A)
  • pregnancy-associated plasma protein A (Pappa)
  • pregnancy-associated plasma protein A, pappalysin 1 (PAPPA)
  • pregnancy-associated plasma protein A, pappalysin 1 (Pappa)
  • 8430414N03Rik protein
  • ASBABP2 protein
  • DIPLA1 protein
  • IGFBP-4ase protein
  • PAG1 protein
  • PAPA protein
  • PAPP-A protein
  • Pappa protein
  • PAPPA1 protein

Protein level used designations for PAPPA

IGF-dependent IGFBP-4 protease , insulin-like growth factor-dependent IGF-binding protein 4 protease , pappalysin-1 , aspecific BCL2 ARE-binding protein 2 , differentially placenta 1 expressed protein , insulin-like growth factor-dependent IGF binding protein-4 protease , pregnacy-associated plasma protein A , PAPPA-like protein , pregnancy-associated plasma protein A-like protein , cleaves insulin-like binding protein-4 (IGFBP-4) , metalloprotease

GENE ID SPECIES
100033920 Equus caballus
18491 Mus musculus
313262 Rattus norvegicus
5069 Homo sapiens
481692 Canis lupus familiaris
282647 Bos taurus
100734958 Cavia porcellus
417245 Gallus gallus
397219 Sus scrofa
443157 Ovis aries
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