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The protein encoded by PDSS2 is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. Additionally we are shipping PDSS2 Proteins (5) and PDSS2 Kits (3) and many more products for this protein.
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PDSS2 encodes a putative tumor suppressor, and its expression is regulated by hypermethylation of its promoter in gastric cancer cells.
Decreased PDSS2 expression is an unfavorable prognostic factor for hepatocellular carcinoma, and PDSS2 has potent anticancer activity in HCC (show FAM126A Antibodies) tissues and HepG2 cells.
Decreased PDSS2 mRNA levels were detected in HCC (show FAM126A Antibodies) tissues of 56 patients, correlated with shorter disease-specific survival, and was identified as an independent prognostic factor
PDSS2 has tumor-suppressing activity in human lung cancer cells by enhancing apoptosis and inhibiting tumorigenic capacity.
Human PDSS2 polymorphisms are associated with podocyte diseases. A deficiency of coenzyme Q10 (show EIF2C2 Antibodies) is manifested in lymphoblastoid cell lines derived from focal segmental glomerulosclerosis patients.
Loss of PDSS2 expression is associated with non-small cell lung cancer.
Data show that expression of either dlp1 or dps1 recovered the thermo-sensitive growth of an E. coli ispB(R321A) mutant and restored IspB activity and production of Coenzyme Q-8.
murine and human solanesyl and decaprenyl diphosphate synthases are heterotetramers composed of newly characterized hDPS1 (show PDSS1 Antibodies) (mSPS1 (show PDSS1 Antibodies)) and hDLP1 (mDLP1).
Expression of PDSS2 is downregulated in human gastric cancer. PDSS2 may be a potent gastric cancer growth suppressor in vitro acting through apoptosis pathways.
kidney-specific loss of mitochondria triggered by oxidative stress may be the cause of renal failure in Pdss2(kd/kd) mice
During cerebellum development, Pdss2 knockout results in severe cerebellum hypoplasia by impairing cell migration and eliciting ectopic apoptosis, whereas Pdss2 knockout in Purkinje cells at postnatal stages leads to the development of cerebellar ataxia.
Data show that focal segmental glomerulopathy-like kidney disease in Pdss2 mutant animals with primary coenzyme Q (CoQ) deficiency is significantly ameliorated by oral treatment with probucol.
kd is mutant allele of novel gene for prenyltransferase-like mitochondrial protein (PLMP). Alternatively spliced. Larger gene product has one domain resembling transprenyltransferase and another similar to geranylgeranyl pyrophosphate synthase (show GGPS1 Antibodies). (PLMP)
murine and human solanesyl and decaprenyl diphosphate synthases are heterotetramers composed of newly characterized hDPS1 (show PDSS1 Antibodies) (mSPS1 (show PDSS1 Antibodies)) and hDLP1 (mDLP1 (show PDSS1 Antibodies)).
a presumed autoimmune kidney disease in mice with the missense Pdss2(kd/kd) genotype can be attributed to a mitochondrial CoQ biosynthetic defect
Dietary supplementation with coenzyme Q10 provides a dramatic rescue of both proteinuria and interstitial nephritis in the Pdss2kd/kd mutant mice.
The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. Defects in this gene are a cause of coenzyme Q10 deficiency.
prenyl (decaprenyl) diphosphate synthase, subunit 2
, prenyl diphosphate synthase, subunit 2
, decaprenyl-diphosphate synthase subunit 2
, decaprenyl-diphosphate synthase subunit 2-like
, all-trans-decaprenyl-diphosphate synthase subunit 2
, decaprenyl pyrophosphate synthase subunit 2
, decaprenyl pyrophosphate synthetase subunit 2
, subunit 2 of decaprenyl diphosphate synthase
, prenyl (decaprenyl) diphosphate synthase subunit 2
, prenyl (solanesyl) diphosphate synthase, subunit 2
, prenyltransferase-like mitochondrial protein
, solanesyl-diphosphate synthase subunit 2