You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Prepronociceptin (PNOC) Antibodies

endogenous ligand of the opioid-like orphan receptor; reduces neuronal excitability and induces an increase in inward rectifying K+ conductance in thalamic neurons. Additionally we are shipping Prepronociceptin Kits (56) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PNOC 25516 Q62923
PNOC 5368 Q13519
PNOC 18155 Q64387
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-Prepronociceptin Antibodies at antibodies-online.com

Showing 10 out of 90 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-PNOC Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human brain tissue reacted with Nociceptin  Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of Nociceptin  Antibody  in HepG2 cell line lysates (35ug/lane). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of PNOC Antibody (Center) (ABIN653261) in HepG2 cell line lysates (35 µg/lane). PNOC (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with PNOC Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded rat brain labeled with Anti-Nociceptin Polyclonal Antibody, Unconjugated (ABIN724535) 1:300 followed by conjugation to the secondary antibody and DAB staining L1 rat brain, L2 rat liver lysates probed (ABIN724535) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band and observed band size: 19kDa. 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Guinea Pig Un-conjugated IHC, IHC (p) Orphanin FQ (nociceptin, OFQ), a heptadecapeptide peptide, has been designated as an endogenous ligand for the ORL1 receptor. The amino acid sequence of OFQ has homology with other opioid peptides, especially the prodynorphin fragment  dynorphin A, suggesting a close evolutionary relationship between the precursors. A diffuse distribution throughout the brain is seen with binding studies and in situ hybridization suggesting an extensive role for OFQ in a multitude of CNS functions. Immunocytochemical localizations in rat spinal cord have demonstrated OFQ abundance in superficial dorsal horn, lateral spinal nucleus and the region dorsal to the central canal. OFQ immunoreactivity was not affected by dorsal rhizotomy, indicating that in spinal cord the peptide is produced by central rather than primary afferent neurons. The localization is supported by its function in processing of nociceptive signals. 0.05 mL Log in to see 5 to 7 Days
$328.13
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IF, IHC (p), IHC, WB 0.05 mL Log in to see 5 to 7 Days
$328.13
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 0.1 mg Log in to see 2 to 6 Days
$359.70
Details
Human Rabbit Un-conjugated WB PNOC antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit Biotin IHC (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

PNOC Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus) , , , ,
,

, , , , , , , , , , ,
Human , , , ,
, , ,
,
, , , , , , , , , , , , , ,
Mouse (Murine) , , , ,
,

, , , , , , , , , , ,

Top referenced anti-Prepronociceptin Antibodies

  1. Human Polyclonal PNOC Primary Antibody for EIA, IHC (p) - ABIN953727 : Rocha, Orozco-Suarez, Alonso-Vanegas, Villeda-Hernandez, Gaona, Páldy, Benyhe, Borsodi: Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex. in Neurobiology of disease 2009 (PubMed)
    Show all 2 references for ABIN953727

  2. Human Polyclonal PNOC Primary Antibody for WB - ABIN2786845 : Williams, Thompson, Rowbotham, Lambert: Human peripheral blood mononuclear cells produce pre-pro-nociceptin/orphanin FQ mRNA. in Anesthesia and analgesia 2008 (PubMed)

More Antibodies against Prepronociceptin Interaction Partners

Human Prepronociceptin (PNOC) interaction partners

  1. Study presents evidence suggesting that the PNOC and OPRL1 (show OPRL1 Antibodies) are dysregulated in suicide completers, thereby potentially contributing to impaired emotional and behavioral control and, ultimately, to the suicidal crisis

  2. findings suggest that SNPs in opioid receptors and the PNOC genes are associated with NAS (show SCN9A Antibodies) severity.

  3. Data suggest that nociceptin and nociceptin receptor (show OPRL1 Antibodies) evolved as one of 4 opioid receptor systems in vertebrates; this system exhibits both analgesic and hyperalgesic effects. [REVIEW]

  4. Data suggest that nociceptin plays a crucial role in progress of meiosis during spermatogenesis. [REVIEW]

  5. Opioid neuropeptide systems are important mediators of ovarian steroid signaling that regulate reproduction in female; data suggest that nociceptin and nociceptin receptor (show OPRL1 Antibodies) system in arcuate nucleus of hypothalamus is such a system. [REVIEW]

  6. Data suggest that both nociceptin and nocistatin inhibit myometrial contractions and may play roles in perception of pain during delivery. [REVIEW]

  7. Data suggest that the nociceptin/nociceptin receptor (show OPRL1 Antibodies) system is involved in modulation of the immune response and in pathogenesis of autoimmune diseases. [REVIEW]

  8. Data suggest that the nociceptin/nociceptin receptor (show OPRL1 Antibodies) system is involved in modulation of psychological and inflammatory stress responses and in pathogenesis of anxiety. [REVIEW]

  9. Data suggest that interaction between the nociceptin/nociceptin receptor (show OPRL1 Antibodies) system and the orexin/orexin (show OX Antibodies) receptor system in neurons of the hypothalamus positively and negatively modulate complex and integrated responses to stress. [REVIEW]

  10. Data suggest that nociceptin/nociceptin receptor (show OPRL1 Antibodies) signaling in neurons of the hippocampus modulate learning and memory. [REVIEW]

Mouse (Murine) Prepronociceptin (PNOC) interaction partners

  1. the present results suggest that the endogenous OFQ/N/NOP (show CRYGB Antibodies) receptor system may modulate the development of cocaine-induced locomotor sensitization.

  2. Data suggest that nociceptin/nociceptin receptor (show OPRL1 Antibodies) signaling plays a role in the disease pathogenesis of inflammatory bowel diseases.

  3. these findings may identify nociceptin as a novel paracrine mediator of the FSH (show BRD2 Antibodies) effects in the regulation of spermatogenesis.

  4. MPTP (show PTPN2 Antibodies) increased by about 5-fold the number of neurons expressing ppN (show PORCN Antibodies)/OFQ mRNA in the pars (show EPRS Antibodies) reticulata of the substantia nigra by 24 h after treatment and the elevation remained significant for at least 7 days.

  5. Endogenous nociceptin/orphanin FQ contributes to reserpine-induced parkinsonism.

  6. N/OFQ and NOP (show CRYGB Antibodies) receptors have an important role in hippocampus-dependent spatial learning and memory, probably by modulation of glutamatergic functions

  7. reduction in endogenous N/OFQ, or the lack of its receptor, causes an increase in capsaicin-induced bronchoconstriction, implying a role for the N/OFQ-NOP (show CRYGB Antibodies) receptor system in the modulation of capsaicin effects

  8. This neuropeptide was tagged with a green fluorescent protein to visualize secretory vesicle dynamics in mouse neuroblastoma (show ARHGEF16 Antibodies) cells and cultures of primary hippocampus neurons.

  9. The N/OFQ receptor (show OPRL1 Antibodies) was seen at high levels in a subset of neurons showing large cell size and indented nucleus in the anterior hypothalamic area.

  10. The nocifensive responses were potentiated in NOP (show CRYGB Antibodies)(-/-) mice

Cow (Bovine) Prepronociceptin (PNOC) interaction partners

  1. The aim of the study was to determine by immunochemistry the expression of leptin (show LEP Antibodies), orexin A and orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow.

Prepronociceptin (PNOC) Antigen Profile

Protein Summary

endogenous ligand of the opioid-like orphan receptor; reduces neuronal excitability and induces an increase in inward rectifying K+ conductance in thalamic neurons

Gene names and symbols associated with anti-Prepronociceptin (PNOC) Antibodies

  • nociceptin-like (LOC100061049) antibody
  • prepronociceptin (PNOC) antibody
  • prepronociceptin (Pnoc) antibody
  • N/OFQ antibody
  • N23K antibody
  • Npnc1 antibody
  • OFQ antibody
  • OFQ/N antibody
  • PNOC antibody
  • PPNOC antibody

Protein level used designations for anti-Prepronociceptin (PNOC) Antibodies

nociceptin , Prepronociceptin (neuropeptide nociceptin) (N23K) , neuropeptide nociceptin 1 , orphanin FQ , nocistatin , propronociceptin , N23K/N27K , proorphanin , prepronociceptin

GENE ID SPECIES
100061049 Equus caballus
422019 Gallus gallus
25516 Rattus norvegicus
5368 Homo sapiens
18155 Mus musculus
281414 Bos taurus
397257 Sus scrofa
100294608 Ovis aries
Selected quality suppliers for anti-Prepronociceptin (PNOC) Antibodies
Did you look for something else?