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endogenous ligand of the opioid-like orphan receptor; reduces neuronal excitability and induces an increase in inward rectifying K+ conductance in thalamic neurons. Additionally we are shipping Prepronociceptin Kits (42) and and many more products for this protein.
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Human Polyclonal PNOC Primary Antibody for EIA, IHC (p) - ABIN953727
Rocha, Orozco-Suarez, Alonso-Vanegas, Villeda-Hernandez, Gaona, Páldy, Benyhe, Borsodi: Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex. in Neurobiology of disease 2009
Show all 2 references for ABIN953727
Human Polyclonal PNOC Primary Antibody for WB - ABIN2786845
Williams, Thompson, Rowbotham, Lambert: Human peripheral blood mononuclear cells produce pre-pro-nociceptin/orphanin FQ mRNA. in Anesthesia and analgesia 2008
Human Polyclonal PNOC Primary Antibody for ICC, IHC (fro) - ABIN250446
Ulugol, Topuz, Gunduz, Kizilay, Karadag: Changes in nociceptin/orphanin FQ levels in rat brain regions after acute and chronic cannabinoid treatment in conjunction with the development of antinociceptive tolerance. in Fundamental & clinical pharmacology 2016
Human Polyclonal PNOC Primary Antibody for WB - ABIN4892213
Laufenberg, Weller, Lang, Ruiz-Velasco: Nociceptin receptor signaling in sympathetic neurons from septic rats. in The Journal of surgical research 2013
The presence of the PNOC rs732636 A allele was associated with the worse Neonatal abstinence syndrome outcomes in infants.
Study presents evidence suggesting that the PNOC and OPRL1 (show OPRL1 Antibodies) are dysregulated in suicide completers, thereby potentially contributing to impaired emotional and behavioral control and, ultimately, to the suicidal crisis
findings suggest that SNPs in opioid receptors and the PNOC genes are associated with NAS (show SCN9A Antibodies) severity.
Data suggest that nociceptin and nociceptin receptor (show OPRL1 Antibodies) evolved as one of 4 opioid receptor systems in vertebrates; this system exhibits both analgesic and hyperalgesic effects. [REVIEW]
Data suggest that nociceptin plays a crucial role in progress of meiosis during spermatogenesis. [REVIEW]
Opioid neuropeptide systems are important mediators of ovarian steroid signaling that regulate reproduction in female; data suggest that nociceptin and nociceptin receptor (show OPRL1 Antibodies) system in arcuate nucleus of hypothalamus is such a system. [REVIEW]
Data suggest that both nociceptin and nocistatin inhibit myometrial contractions and may play roles in perception of pain during delivery. [REVIEW]
Data suggest that the nociceptin/nociceptin receptor (show OPRL1 Antibodies) system is involved in modulation of the immune response and in pathogenesis of autoimmune diseases. [REVIEW]
Data suggest that the nociceptin/nociceptin receptor (show OPRL1 Antibodies) system is involved in modulation of psychological and inflammatory stress responses and in pathogenesis of anxiety. [REVIEW]
Data suggest that interaction between the nociceptin/nociceptin receptor (show OPRL1 Antibodies) system and the orexin/orexin (show OX Antibodies) receptor system in neurons of the hypothalamus positively and negatively modulate complex and integrated responses to stress. [REVIEW]
the present results suggest that the endogenous OFQ/N/NOP (show CRYGB Antibodies) receptor system may modulate the development of cocaine-induced locomotor sensitization.
Data suggest that nociceptin/nociceptin receptor (show OPRL1 Antibodies) signaling plays a role in the disease pathogenesis of inflammatory bowel diseases.
these findings may identify nociceptin as a novel paracrine mediator of the FSH (show BRD2 Antibodies) effects in the regulation of spermatogenesis.
MPTP (show PTPN2 Antibodies) increased by about 5-fold the number of neurons expressing ppN (show PORCN Antibodies)/OFQ mRNA in the pars (show EPRS Antibodies) reticulata of the substantia nigra by 24 h after treatment and the elevation remained significant for at least 7 days.
Endogenous nociceptin/orphanin FQ contributes to reserpine-induced parkinsonism.
N/OFQ and NOP (show CRYGB Antibodies) receptors have an important role in hippocampus-dependent spatial learning and memory, probably by modulation of glutamatergic functions
reduction in endogenous N/OFQ, or the lack of its receptor, causes an increase in capsaicin-induced bronchoconstriction, implying a role for the N/OFQ-NOP (show CRYGB Antibodies) receptor system in the modulation of capsaicin effects
This neuropeptide was tagged with a green fluorescent protein to visualize secretory vesicle dynamics in mouse neuroblastoma (show ARHGEF16 Antibodies) cells and cultures of primary hippocampus neurons.
The N/OFQ receptor (show OPRL1 Antibodies) was seen at high levels in a subset of neurons showing large cell size and indented nucleus in the anterior hypothalamic area.
The nocifensive responses were potentiated in NOP (show CRYGB Antibodies)(-/-) mice
The aim of the study was to determine by immunochemistry the expression of leptin (show LEP Antibodies), orexin A and orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow.
endogenous ligand of the opioid-like orphan receptor; reduces neuronal excitability and induces an increase in inward rectifying K+ conductance in thalamic neurons
, Prepronociceptin (neuropeptide nociceptin) (N23K)
, neuropeptide nociceptin 1
, orphanin FQ