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anti-Presenilin Associated, Rhomboid-Like (PARL) Antibodies

PARL encodes a mitochondrial integral membrane protein. Additionally we are shipping PARL Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PARL 100362085  
PARL 55486 Q9H300
PARL 381038 Q5XJY4
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Top anti-PARL Antibodies at antibodies-online.com

Showing 10 out of 39 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IF, WB Immunocytochemistry of PARL in 3T3 cells with this product at 2.5 μg/ml. Western blot analysis of PARL in 3T3 cell lysate with this product at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated ELISA, WB Figure 1: Western blot analysis using PARL mouse mAb against truncated Trx-PARL recombinant protein (1) and truncated MBP-PARL (aa112-167) recombinant protein (2) . 100 μL Log in to see 3 to 4 Days
$345.40
Details
Human Mouse Un-conjugated WB   100 μL Log in to see 10 to 11 Days
$550.00
Details
Human Rabbit Un-conjugated IHC (p), WB Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE) Western blot analysis of PARL in 3T3 cell lysate with PARL antibody at (A) 1 and (B) 2 µg/ml. 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC, WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$485.83
Details
Human Mouse Un-conjugated ELISA, WB 0.1 mL Log in to see 6 to 11 Days
$414.29
Details
Dog Rabbit Un-conjugated IHC, ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated IHC (p), WB Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details

PARL Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Rat (Rattus) ,


Human ,
, ,
,
Mouse (Murine) ,
,

Top referenced anti-PARL Antibodies

  1. Human Polyclonal PARL Primary Antibody for EIA, IF - ABIN500451 : Walder, Kerr-Bayles, Civitarese, Jowett, Curran, Elliott, Trevaskis, Bishara, Zimmet, Mandarino, Ravussin, Blangero, Kissebah, Collier: The mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes. in Diabetologia 2005 (PubMed)
    Show all 4 references for ABIN500451

  2. Human Monoclonal PARL Primary Antibody for ELISA, WB - ABIN969340 : Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 3 references for ABIN969340

  3. Human Monoclonal PARL Primary Antibody for WB - ABIN2869331 : Pellegrini, Passer, Canelles, Lefterov, Ganjei, Fowlkes, Koonin, DAdamio: PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2. in Journal of Alzheimer's disease : JAD 2002 (PubMed)
    Show all 3 references for ABIN2869331

  4. Cow (Bovine) Polyclonal PARL Primary Antibody for IHC, WB - ABIN2782038 : Yoshioka, Katsu, Sakata, Okami, Wakai, Kinouchi, Chan: The role of PARL and HtrA2 in striatal neuronal injury after transient global cerebral ischemia. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2013 (PubMed)
    Show all 2 references for ABIN2782038

More Antibodies against PARL Interaction Partners

Human Presenilin Associated, Rhomboid-Like (PARL) interaction partners

  1. pathogenic PINK1 (show PINK1 Antibodies) mutants which are not cleaved by PARL affect PINK1 (show PINK1 Antibodies) kinase activity and the ability to induce PARK2 (show PARK2 Antibodies)-mediated mitophagy.

  2. Common genetic variants of the PINK1 (show PINK1 Antibodies) and PARL genes are unlikely to be involved in schizophrenia.

  3. the frequency of the haplotype AAC, and AAT were significantly higher in the unaffected cases and the frequencies of haplotype GGT were significantly higher in LHON cases

  4. Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.

  5. p.S77N variant, and, possibly, mutations in the PARL protein overall, are not a frequent cause of autosomal recessive early-onset Parkinson's disease

  6. work provides unexpected insights into the structural determinants regulating Parl stability and activity in vivo, and reveals a complex cascade of proteolytic events controlling the function of the protease in the mitochondrion

  7. PARL deficiency impairs PARKIN (show PARK2 Antibodies) recruitment to mitochondria.

  8. the PARL-catalyzed removal of the Pink1 (show PINK1 Antibodies) signal sequence in the canonical import pathway acts as a cellular checkpoint for mitochondrial integrity

  9. Mitochondrial protease PARL cleaves PINK1 (show PINK1 Antibodies) at position A103.

  10. Data show that no association between PARL gene SNPs and LHON in Chinese patients with m.11778G>A.

Mouse (Murine) Presenilin Associated, Rhomboid-Like (PARL) interaction partners

  1. Downregulation of PARL after ischemia is a key step in ischemic neuronal injury, and that it decreases HtrA2 (show HTRA2 Antibodies) processing and increases neuronal vulnerability.

  2. the OPA1 (show MED12 Antibodies)/PARL dependent pathway of cristae remodeling is implicated in heat shock.

  3. Suppression of PARL protein in healthy myotubes lowered mitochondrial mass and insulin (show INS Antibodies)-stimulated glycogen (show GYS1 Antibodies) synthesis and increased reactive oxygen species production.

  4. results indicate a different function and mechanism of Hax1 (show HAX1 Antibodies) in apoptosis and re-opens the question of whether mammalian PARL, in addition to apoptosis, regulates mitochondrial stress response through Omi/HtrA2 (show HTRA2 Antibodies) processing.

  5. Parl-/- mitochondria display reduced levels of OPA1 (show MED12 Antibodies), and OPA1 (show MED12 Antibodies) specifically targeted to IMS complements Parl-/- cells, substantiating the importance of PARL in OPA1 (show MED12 Antibodies) processing.(PARL protein, mouse)

  6. Hax1 (show HAX1 Antibodies), is required to suppress apoptosis in lymphocytes and neurons; suppression requires the interaction of Hax1 (show HAX1 Antibodies) with the mitochondrial proteases Parl and HtrA2 (show HTRA2 Antibodies)

PARL Antigen Profile

Protein Summary

This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with PARL

  • presenilin associated, rhomboid-like (PARL) antibody
  • presenilin associated, rhomboid-like (LOC100362085) antibody
  • presenilin associated, rhomboid-like (Parl) antibody
  • D16Ertd607e antibody
  • PRO2207 antibody
  • Psarl antibody
  • PSARL1 antibody
  • PSENIP2 antibody
  • RHBDS1 antibody

Protein level used designations for PARL

mitochondrial intramembrane cleaving protease PARL , mitochondrial intramembrane-cleaving protease PARL , presenilins-associated rhomboid-like protein, mitochondrial , rhomboid 7 homolog 1 , presenilin associated, rhomboid-like isoform 1 preproprotein , presenilin associated, rhomboid-like preproprotein

GENE ID SPECIES
100058851 Equus caballus
100362085 Rattus norvegicus
55486 Homo sapiens
488100 Canis lupus familiaris
514191 Bos taurus
381038 Mus musculus
287979 Rattus norvegicus
424767 Gallus gallus
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