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During primary cilia disassembly, involved in cilia disassembly.
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Pitchfork and Gprasp2 (show GPRASP2 Proteins) Target Smoothened to the Primary Cilium for Hedgehog (show SHH Proteins) Pathway Activation.
The proper expression levels of Pitchfork might play a pivotal role in normal secondary palate morphogenesis.
1700027A23Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Pitchfork (Pifo) associates with ciliary targeting complexes and accumulates at the basal body during cilia disassembly. Haploinsufficiency causes a unique node cilia duplication phenotype, left-right asymmetry defects, and heart failure.
During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner (By similarity).