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Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. Additionally we are shipping Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 1 Antibodies (28) and Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 1 Kits (18) and many more products for this protein.
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Data show that homozygous and compound heterozygous changes found in PLOD1 and SLC2A10 (show SLC2A10 Proteins) may confer autosomal recessive effects, and three MYH11 (show MYH11 Proteins), ACTA2 (show ACTA2 Proteins) and COL3A1 (show COL3A1 Proteins) heterozygous variants were considered as putative pathogenic gene alterations.
Common polymorphisms in four candidate genes (COL11A1, COL18A1 (show COL18A1 Proteins), FBN1 (show FBN1 Proteins) and PLOD1) were unlikely to play important roles in the genetic susceptibility to high myopia.
Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3. The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activity
Results indicate that a C-terminal 40 amino acid segment of lysyl hydroxylase confers endoplasmic reticulum residency in a KDEL-receptor-independent manner.
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity.
, lysyl hydroxylase 1
, procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1
, procollagen-lysine 2-oxoglutarate 5-dioxygenase (lysine hydroxylase Ehlers-Danlos syndrome type VI)
, procollagen-lysine, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase, Ehlers-Danlos syndrome type VI)
, procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
, lysine hydroxylase
, lysyl hydroxlase 1
, 2-oxoglutarate 5-dioxygenase 1
, procollagen-lysine 5-dioxygenase
, procollagen-lysine 2-oxoglutarate 5-dioxygenase 1