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anti-Profilin 1 (PFN1) Antibodies

The protein encoded by PFN1 is a ubiquitous actin monomer-binding protein belonging to the profilin family. Additionally we are shipping Profilin 1 Proteins (30) and Profilin 1 Kits (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PFN1 5216 P07737
PFN1 18643 P62962
PFN1 64303 P62963
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Top anti-Profilin 1 Antibodies at

Showing 10 out of 91 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Cow Rabbit Un-conjugated IHC, IHC (p), SimWes, WB 0.1 mL Log in to see 5 to 7 Days
Human Rabbit Un-conjugated WB 0.1 mL Log in to see 5 to 7 Days
Human Rabbit Un-conjugated WB Anti- Profilin1 Picoband antibody, Western blotting All lanes: Anti Profilin1  at 0.5ug/ml Lane 1: Rat Testis Tissue Lysate at 50ug Lane 2: Mouse Testis Tissue Lysate at 50ug Lane 3: Human Placenta Tissue Lysate at 50ug Lane 4: PANC Whole Cell Lysate at 40ug Lane 5: SW620 Whole Cell Lysate at 40ug Predicted bind size: 15KD Observed bind size: 15KD 100 μg Log in to see 4 to 6 Days
Cow Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: 293T B: A431 C: HeLa D: HepG2 15% SDS PAGE antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded MDA-MB-231 xenograft, using Profilin 1, antibody at 1:500 dilution. 100 μL Log in to see 2 to 3 Days
Human Mouse Un-conjugated FACS, IF, IHC, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PFN1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PFN1. Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-PFN1 mouse monoclonal antibody. (ABIN2453453, Dilution 1:50) 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: Profilin 1 Antibody [NBP2-19941] - Immunohistochemical analysis of paraffin-embedded MDA-MB-231 xenograft, using antibody at 1:500 dilution. Western Blot: Profilin 1 Antibody [NBP2-19941] - Sample (30 ug of whole cell lysate) A: 293T B: A431 C: HeLa D: HepG2 15% SDS PAGE gel, diluted at 1:1000. 0.1 mL Log in to see 6 to 9 Days
Human Rabbit Un-conjugated WB Western blot analysis of Profilin 1 expression in HT29 (A), PC12 (B), COS7 (C) whole cell lysates. 200 μL Log in to see 9 Days
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days

PFN1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Profilin 1 Antibodies

  1. Human Polyclonal PFN1 Primary Antibody for WB - ABIN152302 : Salazar, Bell, Davis: Coordinate induction of the actin cytoskeletal regulatory proteins gelsolin, vasodilator-stimulated phosphoprotein, and profilin during capillary morphogenesis in vitro. in Experimental cell research 1999 (PubMed)
    Show all 5 references for ABIN152302

  2. Cow (Bovine) Polyclonal PFN1 Primary Antibody for WB - ABIN2783306 : Wen, McKane, Houtman, Rubenstein: Control of the ability of profilin to bind and facilitate nucleotide exchange from G-actin. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for ABIN2783306

  3. Cow (Bovine) Polyclonal PFN1 Primary Antibody for IHC, IHC (p) - ABIN446701 : van Blitterswijk, Baker, Bieniek, Knopman, Josephs, Boeve, Caselli, Wszolek, Petersen, Graff-Radford, Boylan, Dickson, Rademakers: Profilin-1 mutations are rare in patients with amyotrophic lateral sclerosis and frontotemporal dementia. in Amyotrophic lateral sclerosis & frontotemporal degeneration 2013 (PubMed)

More Antibodies against Profilin 1 Interaction Partners

Human Profilin 1 (PFN1) interaction partners

  1. Gain-of-toxic-function PFN1 gene mutation leads to conformational change of TDP-43 (show TARDBP Antibodies) and to neurodegeneration in amyotrophic lateral sclerosis.

  2. Profilin synergizes with chemotherapeutic drugs to induce tumor cell death by regulating NF-kappaB (show NFKB1 Antibodies) and p53 (show TP53 Antibodies). Thus, modulation of Profilin may be a useful strategy for effective combination therapy.

  3. Mutations of profilin-1, associated with familial amyotrophic lateral sclerosis, increase the tendency of profilin-1 to aggregate and that such aggregation behavior is largely determined by the mutation-induced structural changes occurring in the folded state of the protein.

  4. evidence, which suggests that Profilin increases tumour suppressor activity by regulating NF-kappaB (show NFKB1 Antibodies).

  5. Profilin-1 folding process occurs in the absence of thermodynamically stable partially folded states.

  6. Actin independent mechanisms contribute to the pathogenicity of PFN1 T109M and possibly other PFN1 mutations.

  7. expression of the ALS (show IGFALS Antibodies)-associated actin-binding deficient mutant of PFN1 (PFN1(C71G)) results in increased dendritic arborisation and spine formation, and cytoplasmic inclusions in cultured mouse hippocampal neurons

  8. PFN1 is a rare cause of ALS.

  9. findings suggest that a destabilized form of PFN1 underlies PFN1-mediated ALS pathogenesis

  10. Suggest that PFN1 plays a critical role in gastric carcinoma progression, and these effects are likely mediated through the integrin beta1/FAK (show PTK2 Antibodies) pathway.

Mouse (Murine) Profilin 1 (PFN1) interaction partners

  1. overexpression of profilin is sufficient to induce cardiomyocyte hypertrophy and sarcomeric remodelling, and silencing of profilin attenuates the hypertrophic response

  2. Pfn1 is a novel target of BMP and suppresses BMP-induced differentiation of osteoblasts at least in part via transcriptional event.

  3. knockdown of either profilin 1 or profilin 2a led to a significant decrease in cell spreading of astrocytes. Moreover, both isoforms proved to be crucial for forskolin-induced astrocytic stellation.

  4. Inactivation of profilin 1 impaired the radial migration of cerebellar granule neurons

  5. Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like (show WASL Antibodies) platelet defect.

  6. Depleting FMNL1 (show FMNL1 Antibodies), another Formin (show FMN1 Antibodies) family member, resulted in reduced mDia1 expression, while RhoA (show RHOA Antibodies) inhibition did not alter mDia1 expression, which indicated that there was a FMNL1 (show FMNL1 Antibodies)-mDia1-Profilin1 signaling pathway in mouse oocytes.

  7. association of cortactin (show CTTN Antibodies) with Pfn-1 is regulated by c-Abl (show ABL1 Antibodies)-mediated cortactin (show CTTN Antibodies) phosphorylation

  8. In glioblastomas endothelial cell-specific Pfn-1 phosphorylation elevates HIF-1alpha (show HIF1A Antibodies) expression leading to vascular abnormalities and tumor progression.

  9. Pfn1 as a key effector of the integrin linked kinase/Rho/ROCK pathway which acts in parallel with integrin beta1/LCK/Rac1 and regulates Schwann cells lamellipodia formation, radial sorting and myelination during peripheral nervous system maturation.

  10. pfn1 at least partially acts through the axis of pfn1/Galpha13 (show GNA13 Antibodies)/EGR1 (show EGR1 Antibodies) to regulate stem cell retention and metabolism in the bone marrow.

Cow (Bovine) Profilin 1 (PFN1) interaction partners

  1. biophysical analysis reveals that the open nucleotide pocket of the profilin/actin x-ray structure is unstable and closes in the absence of profilin

  2. nitric oxide and free radicals produced under different conditions could alter the functions of profilin through nitration, such as its interaction with actin and poly (l-proline).

  3. Profilin regulates actin dynamics both within the cytoplasm and inside the nuclei of developing mammalian embryos.

  4. Phosphorylation studies indicate that profilin dimers are not phosphorylated while teramers are preferentially phosphorylated over monomers.

Arabidopsis thaliana Profilin 1 (PFN1) interaction partners

  1. PRF1 coordinates the stochastic dynamic properties of actin filaments by modulating formin-mediated actin nucleation and assembly during plant cell expansion.

  2. formed a filamentous network likely associated with actin filaments

Caenorhabditis elegans (C. elegans) Profilin 1 (PFN1) interaction partners

  1. protein CYK-1 and the profilin PFN-1 mediate the Arp2/3-independent assembly of cortical microfilaments and are required for cytokinesis in the early embryo

  2. Thus the model organism Caenorhabditis elegans expresses three profilin isoforms and is the first invertebrate animal with tissue-specific profilin expression.

  3. profilin promotes actin organisation

Profilin 1 (PFN1) Antigen Profile

Protein Summary

This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1.

Gene names and symbols associated with anti-Profilin 1 (PFN1) Antibodies

  • profilin (PRO2) antibody
  • profilin 1 (PFN1) antibody
  • profilin 1 (pfn1) antibody
  • profilin 1 (Pfn1) antibody
  • profilin 1 (PRF1) antibody
  • profilin 1-like (LOC100350198) antibody
  • profilin homolog1 (prf1) antibody
  • profilin-1-like (LOC607397) antibody
  • Protein PFN-1 (pfn-1) antibody
  • ALS18 antibody
  • F6F22.21 antibody
  • F6F22_21 antibody
  • GmPRO1 antibody
  • GmPRO2 antibody
  • MGC130883 antibody
  • Pfn antibody
  • PFN1 antibody
  • PRO1 antibody
  • profilin antibody
  • profilin-1 antibody
  • profilin 1 antibody
  • Profilin1 antibody
  • sb:cb813 antibody
  • wu:fa91a03 antibody
  • XProfilin1 antibody

Protein level used designations for anti-Profilin 1 (PFN1) Antibodies

profilin-2 , profilin 1 , fa91a03 , epididymis tissue protein Li 184a , profilin I , profilin-1 , actin binding protein , CL2097_1 , CL2097_1(520) , CL2097_1_ov , ZmPRO1

547670 Glycine max
710753 Macaca mulatta
735169 Xenopus laevis
799355 Danio rerio
100170559 Xenopus (Silurana) tropicalis
5216 Homo sapiens
100512494 Sus scrofa
18643 Mus musculus
64303 Rattus norvegicus
513895 Bos taurus
100723625 Cavia porcellus
816495 Arabidopsis thaliana
100350198 Oryctolagus cuniculus
542409 Zea mays
607397 Canis lupus familiaris
173161 Caenorhabditis elegans
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