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Profilin 1 Proteins (PFN1)

PFN1 encodes a member of the profilin family of small actin-binding proteins. Additionally we are shipping Profilin 1 Antibodies (73) and Profilin 1 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PFN1 5216 P07737
PFN1 18643 P62962
PFN1 64303 P62963
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Top Profilin 1 Proteins at antibodies-online.com

Showing 10 out of 30 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$242.00
Details
HOST_Escherichia coli (E. coli) Human GST tag Profilin 1 (PFN1) (AA 2-140), (full length) protein (GST tag) 1 mg Log in to see 56 to 66 Days
$1,842.50
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$616.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
$788.70
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast REACT_Apple His tag   1 mg Log in to see 56 to 66 Days
$2,267.83
Details
Yeast REACT_Timothy grass His tag   1 mg Log in to see 56 to 66 Days
$2,267.83
Details
Yeast Phaseolus vulgaris His tag   1 mg Log in to see 56 to 66 Days
$2,267.83
Details

PFN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)
,
Rat (Rattus)

Top referenced Profilin 1 Proteins

  1. Human PFN1 Protein expressed in Escherichia coli (E. coli) - ABIN666790 : Harbeck, Hüttelmaier, Schluter, Jockusch, Illenberger: Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for ABIN666790

More Proteins for Profilin 1 (PFN1) Interaction Partners

Human Profilin 1 (PFN1) interaction partners

  1. evidence, which suggests that Profilin increases tumour suppressor activity by regulating NF-kappaB (show NFKB1 Proteins).

  2. Profilin-1 folding process occurs in the absence of thermodynamically stable partially folded states.

  3. Actin independent mechanisms contribute to the pathogenicity of PFN1 T109M and possibly other PFN1 mutations.

  4. expression of the ALS (show IGFALS Proteins)-associated actin-binding deficient mutant of PFN1 (PFN1(C71G)) results in increased dendritic arborisation and spine formation, and cytoplasmic inclusions in cultured mouse hippocampal neurons

  5. PFN1 is a rare cause of ALS.

  6. findings suggest that a destabilized form of PFN1 underlies PFN1-mediated ALS pathogenesis

  7. Suggest that PFN1 plays a critical role in gastric carcinoma progression, and these effects are likely mediated through the integrin beta1/FAK (show PTK2 Proteins) pathway.

  8. Data indicated that No PFN1 mutations were identified in the Catalan population with amyotrophic lateral sclerosis.

  9. Profilin-1 overexpression in MDA-MB-231 breast cancer cells is associated with alterations in proteomics biomarkers of cell proliferation, survival, and motility as revealed by global proteomics analyses

  10. Profilin1 acts as a molecular regulator of the levels of PI(3,4)P2 and Tks5 recruitment in invadopodia to control the invasion efficiency of invadopodia.

Mouse (Murine) Profilin 1 (PFN1) interaction partners

  1. knockdown of either profilin 1 or profilin 2a led to a significant decrease in cell spreading of astrocytes. Moreover, both isoforms proved to be crucial for forskolin-induced astrocytic stellation.

  2. Inactivation of profilin 1 impaired the radial migration of cerebellar granule neurons

  3. Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like (show WASL Proteins) platelet defect.

  4. Depleting FMNL1 (show FMNL1 Proteins), another Formin (show FMN1 Proteins) family member, resulted in reduced mDia1 expression, while RhoA (show RHOA Proteins) inhibition did not alter mDia1 expression, which indicated that there was a FMNL1 (show FMNL1 Proteins)-mDia1-Profilin1 signaling pathway in mouse oocytes.

  5. association of cortactin (show CTTN Proteins) with Pfn-1 is regulated by c-Abl (show ABL1 Proteins)-mediated cortactin (show CTTN Proteins) phosphorylation

  6. In glioblastomas endothelial cell-specific Pfn-1 phosphorylation elevates HIF-1alpha (show HIF1A Proteins) expression leading to vascular abnormalities and tumor progression.

  7. Pfn1 as a key effector of the integrin linked kinase/Rho/ROCK pathway which acts in parallel with integrin beta1/LCK/Rac1 and regulates Schwann cells lamellipodia formation, radial sorting and myelination during peripheral nervous system maturation.

  8. pfn1 at least partially acts through the axis of pfn1/Galpha13 (show GNA13 Proteins)/EGR1 (show EGR1 Proteins) to regulate stem cell retention and metabolism in the bone marrow.

  9. findings indicate that pfn haploinsufficiency protects against diet-induced insulin (show INS Proteins) resistance and inflammation by modulating white adipose tissue immune homeostasis.

  10. The results of this study found that the profilin1 is crucially important for brain development, but dispensable for the physiology of excitatory synapses.

Cow (Bovine) Profilin 1 (PFN1) interaction partners

  1. biophysical analysis reveals that the open nucleotide pocket of the profilin/actin x-ray structure is unstable and closes in the absence of profilin

  2. nitric oxide and free radicals produced under different conditions could alter the functions of profilin through nitration, such as its interaction with actin and poly (l-proline).

  3. Profilin regulates actin dynamics both within the cytoplasm and inside the nuclei of developing mammalian embryos.

  4. Phosphorylation studies indicate that profilin dimers are not phosphorylated while teramers are preferentially phosphorylated over monomers.

Arabidopsis thaliana Profilin 1 (PFN1) interaction partners

  1. PRF1 coordinates the stochastic dynamic properties of actin filaments by modulating formin-mediated actin nucleation and assembly during plant cell expansion.

  2. formed a filamentous network likely associated with actin filaments

Caenorhabditis elegans (C. elegans) Profilin 1 (PFN1) interaction partners

  1. protein CYK-1 and the profilin PFN-1 mediate the Arp2/3-independent assembly of cortical microfilaments and are required for cytokinesis in the early embryo

  2. Thus the model organism Caenorhabditis elegans expresses three profilin isoforms and is the first invertebrate animal with tissue-specific profilin expression.

  3. profilin promotes actin organisation

Profilin 1 (PFN1) Protein Profile

Protein Summary

This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1.

Gene names and symbols associated with Profilin 1 Proteins (PFN1)

  • profilin (PRO2)
  • profilin 1 (PFN1)
  • profilin 1 (pfn1)
  • profilin 1 (Pfn1)
  • profilin 1 (PRF1)
  • profilin 1-like (LOC100350198)
  • profilin homolog1 (prf1)
  • profilin-1-like (LOC607397)
  • Protein PFN-1 (pfn-1)
  • ALS18 protein
  • F6F22.21 protein
  • F6F22_21 protein
  • GmPRO1 protein
  • GmPRO2 protein
  • MGC130883 protein
  • Pfn protein
  • PFN1 protein
  • PRO1 protein
  • profilin protein
  • profilin-1 protein
  • profilin 1 protein
  • Profilin1 protein
  • sb:cb813 protein
  • wu:fa91a03 protein
  • XProfilin1 protein

Protein level used designations for Profilin 1 Proteins (PFN1)

profilin-2 , profilin 1 , fa91a03 , epididymis tissue protein Li 184a , profilin I , profilin-1 , actin binding protein , CL2097_1 , CL2097_1(520) , CL2097_1_ov , ZmPRO1

GENE ID SPECIES
547670 Glycine max
710753 Macaca mulatta
735169 Xenopus laevis
799355 Danio rerio
100170559 Xenopus (Silurana) tropicalis
5216 Homo sapiens
100512494 Sus scrofa
18643 Mus musculus
64303 Rattus norvegicus
513895 Bos taurus
100723625 Cavia porcellus
816495 Arabidopsis thaliana
100350198 Oryctolagus cuniculus
542409 Zea mays
607397 Canis lupus familiaris
173161 Caenorhabditis elegans
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