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Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.. Additionally we are shipping PAQR3 Antibodies (17) and many more products for this protein.
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our results suggested that the aberrant methylation of PAQR3 underlies its downregulation in breast cancer and our data indicated that epigenetic silencing of PAQR3 gene expression by promoter hypermethylation may play an important role in breast cancer
PAQR3 plays a tumor suppressive role in laryngeal squamous cell carcinoma
A novel role for the newly characterized, Golgi-localized PAQR3 in regulating heterotrimeric G-proteins at the non-canonical subcellular location of the Golgi.
findings not only pinpoint that Twist1 (show TWIST1 Proteins) mediates the modulatory function of PAQR3 on EMT (show ITK Proteins) and metastasis but also suggest that targeting Twist1 (show TWIST1 Proteins) is a promising strategy to control metastasis of tumors with downregulation of PAQR3
PAQR3 regulates cholesterol homeostasis by anchoring Scap/SREBP to the Golgi and disruption of such function reduces cholesterol biosynthesis.
Our data indicate that PAQR3 functions as a tumor suppressor in the development of human breast cancers.
DDB2 (show DDB2 Proteins) is involved in ubiquitination and degradation of PAQR3 in gastric cancer cells.
PAQR3 is markedly down-regulated in human gastric cancers. PAQR3 expression level is closely associated with the progression and metastasis of gastric cancers
PAQR3 might act as a tumor suppressor in osteosarcoma.
PAQR3 may play an important role in the progression of hepatocellular carcinoma and serve as a potential candidate for the targeted therapy of hepatocellular carcinoma
PAQR3 controls autophagy by integrating AMPK (show PRKAA1 Proteins) signaling to enhance ATG14L-associated PI3K activity
This study reveals that PAQR3 has an important physiological function in modulating obesity, energy metabolism, and leptin (show LEP Proteins) signaling.
PAQR3 negatively regulates insulin (show INS Proteins) signaling by shunting cytosolic p110alpha (show PIK3CA Proteins) to the Golgi apparatus while competing with p85 (show ECM1 Proteins) subunit in forming a PI3K complex with p110alpha (show PIK3CA Proteins).
Loss of PAQR3 is associated with tumorigenesis of colorectal cancers.
reveal a paradigm of spatial regulation of Raf (show RAF1 Proteins) kinase by RKTG via sequestrating Raf-1 (show RAF1 Proteins) to the Golgi apparatus and thereby inhibiting the ERK (show EPHB2 Proteins) signaling pathway.
RKTG has a suppressive activity in chemical carcinogen-induced mitogenesis and tumor formation in mouse skin.
Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.
Raf kinase trapping to Golgi
, progestin and adipoQ receptor family member 3