anti-Programmed Cell Death 1 (PDCD1) Antibodies

May have a role in the regulation of spermatogenesis.. Additionally we are shipping PD-1 Proteins (93) and PD-1 Kits (25) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PDCD1 5133 Q15116
PDCD1 301626  
PDCD1 18566 Q02242
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Top anti-PD-1 Antibodies at antibodies-online.com

Showing 10 out of 662 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Anti-PD1 Picoband antibody ,  All lanes: Anti PD1  at 0.5ug/ml Lane 1: JURKAT Whole Cell Lysate at 40ug Lane 2: Human Placenta Tissue Lysate at 50ug Predicted bind size: 32KD Observed bind size: 38KD Anti-PD1 Picoband antibody ,  All lanes: Anti PD1  at 0.5ug/ml WB: Recombinant Human PD1 Protein 0.5ng Predicted bind size: 38KD Observed bind size: 38KD 100 μg Log in to see 4 to 6 Days
$200.00
Details
Mouse Goat PE FACS Detection of PD-1 in Mouse CD4+ T-Cells by Flow Cytometry. Mouse CD4+ T-cells were stained with Goat Anti-Mouse PD-1 PE-conjugated Antigen Affinity-purified Polyclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$351.90
Details
Human Goat Biotin ELISA (Detection), FACS, WB Detection of PD-1 in Human PBMCs treated with PHA by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) either (A) untreated or (B) treated with 5 ug/mL PHA overnight were stained with Goat Anti-Human PD-1 Biotinylated Antigen Affinity-purified Polyclonal Antibody. 50 μg Log in to see 8 to 9 Days
$451.95
Details
Mouse Goat Un-conjugated CyTOF, FACS, IHC, WB PD-1 in Mouse Spleen. PD-1 was detected in perfusion fixed frozen sections of mouse spleen using Goat Anti-Mouse PD-1 Antigen Affinity-purified Polyclonal Antibody. Specific staining was localized to cytoplasm in splenocytes. PD-1 in Mouse Thymus. PD-1 was detected in perfusion fixed frozen sections of mouse thymus using 15 µ 100 μg Log in to see 8 to 9 Days
$440.45
Details
Human Rabbit Un-conjugated WB Western blot analysis of CD279 expression in THP1 (A), HepG2 (B), mouse liver (C), H9C2 (D) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Goat Un-conjugated ELISA, WB ABIN185400 (0.6µg/ml) staining of Human Bone Marrow lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Mouse Un-conjugated EIA, WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Mouse Hamster Biotin FACS 0.1 mg Log in to see 6 to 8 Days
$308.00
Details
Mouse Hamster Un-conjugated FACS 0.25 mg Log in to see 6 to 8 Days
$379.50
Details
Human Mouse Un-conjugated CyTOF, FACS, WB Detection of PD-1 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) either (A) untreated or (B) treated with 5 ng/mL PHA for 2 days were stained with Mouse Anti-Human PD-1 Monoclonal Antibody. Detection of Human PD-1 by Western Blot. Western blot shows lysates of HEK293 human embryonic kidney cell line either mock transfected or transfected with human PD-1. PVDF membrane was probed with 1 ug/mL of Mouse Anti-Human PD-1 Monoclonal Antibody. This experiment was conducted under reducing conditions. 100 μg Log in to see 8 to 9 Days
$346.15
Details

PDCD1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-PD-1 Antibodies

  1. Human Monoclonal PD-1 Primary Antibody for BR, FACS - ABIN2689142 : Bennett, Luxenberg, Ling, Wang, Marquette, Lowe, Khan, Veldman, Jacobs, Valge-Archer, Collins, Carreno: Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses. in Journal of immunology (Baltimore, Md. : 1950) 2003 (PubMed)
    Show all 8 Pubmed References

  2. Mouse (Murine) Monoclonal PD-1 Primary Antibody for BR, FACS - ABIN2689141 : Nishimura, Agata, Kawasaki, Sato, Imamura, Minato, Yagita, Nakano, Honjo: Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes. in International immunology 1997 (PubMed)
    Show all 7 Pubmed References

  3. Human Polyclonal PD-1 Primary Antibody for ELISA (Detection), FACS - ABIN4899871 : Sakthivel, Ramanujam, Wang, Pirskanen, Lefvert: Programmed Death-1: from gene to protein in autoimmune human myasthenia gravis. in Journal of neuroimmunology 2008 (PubMed)
    Show all 7 Pubmed References

  4. Human Polyclonal PD-1 Primary Antibody for IHC, ELISA - ABIN1002980 : Holling, Schooten, van Den Elsen: Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. in Human immunology 2004 (PubMed)
    Show all 4 Pubmed References

  5. Human Polyclonal PD-1 Primary Antibody for IHC, ELISA - ABIN1002981 : Ishida, Agata, Shibahara, Honjo: Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. in The EMBO journal 1992 (PubMed)
    Show all 4 Pubmed References

  6. Human Monoclonal PD-1 Primary Antibody for ICC, FACS - ABIN438813 : Dorrell, Abraham, Lanxon-Cookson, Canaday, Streeter, Grompe: Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers. in Stem cell research 2009 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal PD-1 Primary Antibody for IF (p), IHC (p) - ABIN735608 : Zhang, Niyazi, Hong, Tuluwengjiang, Zhang, Zhang, Su, Bao: Effect of EBI3 on radiation-induced immunosuppression of cervical cancer HeLa cells by regulating Treg cells through PD-1/PD-L1 pathway. in Tumour biology 2017 (PubMed)
    Show all 2 Pubmed References

  8. Mouse (Murine) Monoclonal PD-1 Primary Antibody for IHC (fro), FACS - ABIN2479661 : Yamaoka, Furusawa, Fujimoto, Iguchi, Kumai: Muscle spindles in the mylohyoid muscle of rats. in International journal of oral and maxillofacial surgery 1992 (PubMed)
    Show all 3 Pubmed References

  9. Human Monoclonal PD-1 Primary Antibody for FACS - ABIN2479655 : Ochonisky, Chosidow, Kuentz, Man, Fraitag, Pelisse, Revuz: Cogan's syndrome. An unusual etiology of urticarial vasculitis. in Dermatologica 1992 (PubMed)
    Show all 3 Pubmed References

  10. Human Monoclonal PD-1 Primary Antibody for FACS - ABIN2479654 : Kanai, Totsuka, Uraushihara, Makita, Nakamura, Koganei, Fukushima, Akiba, Yagita, Okumura, Machida, Iwai, Azuma, Chen, Watanabe: Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. in Journal of immunology (Baltimore, Md. : 1950) 2003 (PubMed)
    Show all 3 Pubmed References

More Antibodies against PD-1 Interaction Partners

Human Programmed Cell Death 1 (PDCD1) interaction partners

  1. The majority of primary penile penile squamous cell carcinoma (SqCC) tumors express PD-L1 (show CD274 Antibodies), which is associated with high-risk clinicopathologic features and poor clinical outcome. These data provide a rational basis for further investigation of anti-PD-1 and anti-PD-L1 (show CD274 Antibodies) immunotherapeutics in patients with advanced penile SqCC

  2. Of several immunotherapies being investigated, antibodies that target the programmed cell death protein-1 (nivolumab and pembrolizumab) and cytotoxic T-lymphocyte antigen-4 (show CTLA4 Antibodies) (ipilimumab) immune checkpoint pathways are among the most promising for patients with Small cell lung cancer (SCLC), and are the focus of this review.

  3. In this review, we discuss deepening insights into human genetics and our understanding of the interface with rheumatoid arthritis pathogenesis providing a strong rationale for exploiting the co-inhibitory receptor programmed cell death-1 signaling pathway as a better approach for the treatment of this chronic, often progressive destructive joint disease.

  4. PD-L1 (show CD274 Antibodies) expression was related to a poor prognosis in patients with gastric cancer. Furthermore, PD-1 expression on T-cells was up-regulated in patients with tumors with PD-L1 (show CD274 Antibodies) expression

  5. PD-1/PD-L1 (show CD274 Antibodies) inhibitors have produced significant improvements in overall survival compared with single-agent docetaxel delivered in the second-line setting, effectively establishing a new standard of care in non-small cell lung cancer.

  6. Study didn't find any association between PD-1 expression and clinicopathological factors or outcomes in esophageal squamous cell carcinoma.

  7. Data suggest the anti-programmed death-1 (PD-1) antibody pembrolizumab treatment induced favorable responses in a heavily pretreated patient cohort, justifying further studies.

  8. The efficacy and safety of VEGFR (show KDR Antibodies)-TKIs after PD-1 inhibition were demonstrated in this retrospective study. The response rate was lower and the median progression-free survival was shorter in those patients who received prior PD-1 in combination with VEGFR (show KDR Antibodies)-TKI. PD-1 exposure does not seem to significantly influence the safety of subsequent VEGFR (show KDR Antibodies)-TKI treatment

  9. Serum sPD (show HOXD13 Antibodies)-1 is positively correlated with the severity of sepsis, and it is valuable for risk stratification of patients and prediction of 28-day mortality.

  10. We identified that there are significant differences between the tumor microenvironment of paired primary lung cancers and brain metastases. When physicians decide to treat patients with lung cancer with a PD-1 or PD-L1 (show CD274 Antibodies) inhibitor, they must do so in the context of the spatial and temporal heterogeneity of the tumor microenvironment

Mouse (Murine) Programmed Cell Death 1 (PDCD1) interaction partners

  1. Data (including data from studies in transgenic/knockout mice) suggest that T-cell expression of Mirn155 is required to limit melanoma growth; miR (show MLXIP Antibodies)-155, Pdcd1, Pdcd1l1 (show CD274 Antibodies), and Ctla4 (show CTLA4 Antibodies) appear to regulate overlapping pathways promoting antitumor immunity. [Mirn155 = microRNA 155; Pdcd1 = programmed cell death 1 protein; Pdcd1l1 (show CD274 Antibodies) = programmed cell death 1 ligand 1 (show CD274 Antibodies) protein; Ctla4 (show CTLA4 Antibodies) = cytotoxic T-lymphocyte-associated protein 4 (show CTLA4 Antibodies)]

  2. PD-1 plays a vital role in brain inflammation via regulation of Fgl-2 (show FGL2 Antibodies) after ICH (show ACE Antibodies), and that manipulation of PD-1 might be a promising therapeutical target in ICH (show ACE Antibodies).

  3. We identified PD-1 to be specifically expressed in PLZF (show ZBTB16 Antibodies)(+) ILCp and revealed that the timing and order of expression of the transcription factors NFIL3 (show NFIL3 Antibodies), ID2, and TCF-1 (show HNF1A Antibodies) was critical. Importantly, induction of ILC (show CCL27 Antibodies) lineage commitment required only transient expression of NFIL3 (show NFIL3 Antibodies) prior to ID2 and TCF-1 (show HNF1A Antibodies) expression.

  4. The identification of the role for PD-1 in regulating B cell-dependent antitumor immunity to Tn antigen highlights an opportunity to develop new therapeutic strategies targeting tumor-associated carbohydrate antigens

  5. These findings suggest that PD-1 pathway blockade may reverse adaptive immune resistance following cyclic dinucleotide treatment, enhancing both local and systemic antitumor immunity.

  6. data suggest that increased expression of checkpoint blockade molecules PD-1 and CTLA-4 (show CTLA4 Antibodies) on donor T cells is not sufficient to prevent GvHD, and that cooperation between checkpoint blockade signaling by host cells and donor Tregs is necessary to limit GvHD in allo-HSCT recipients

  7. PD-1 Blockade Promotes Epitope Spreading in Anticancer CD8 (show CD8A Antibodies)(+) T Cell Responses by Preventing Fratricidal Death of Subdominant Clones To Relieve Immunodomination

  8. Adoptive transfer of murine T cells expressing a chimeric-PD1-Dap10 (show HCST Antibodies) receptor may induce a preferential cytokine profile and T-cell differentiation phenotype for anti-lymphoma therapies.

  9. soluble PD-1 is elevated in critical illness and may represent a potential biomarker for Acute respiratory distress syndrome.

  10. Together, our results suggest an important role of PD-1 in glioma-induced immune escape, and provide translational evidence for the use of PD-1 blocking antibodies in human malignant gliomas.

Rhesus Monkey Programmed Cell Death 1 (PDCD1) interaction partners

  1. Data show that CTLA-4 (show CTLA4 Antibodies)(+)PD-1(-) memory CD4 (show CD4 Antibodies)(+) T cells, which share phenotypic markers with regulatory T cells, were enriched in SIV DNA in blood, lymph nodes (LN), spleen, and gut (show GUSB Antibodies), and contained replication-competent and infectious virus.

  2. Compared to before immunosuppression, PD-1 expression increased at reactivation. Increased T cells before zoster is likely due to virus reactivation.

  3. A PD-1(high) phenotype is associated with accelerated in vivo CD8 (show CD8A Antibodies) T cell turnover in SIV-infections, especially within the SIV-specific CD8 (show CD8A Antibodies) T cell pool.

  4. High levels of PD-1 expression on CD4 (show CD4 Antibodies)(+) T cells in lymph nodes of rhesus macaques can serve as a valuable marker to identify T follicular helper cells.

  5. Data indicate that PD-1 expression is increased as a result of T cell activation during a primary immune response as well as during persistent immune activation in macaques.

  6. PD-1 can serve as a sensitive indicator of persistent, low-level virus replication

PD-1 (PDCD1) Antigen Profile

Protein Summary

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.

Gene names and symbols associated with PDCD1

  • programmed cell death 1 (PDCD1) antibody
  • programmed cell death 1 (Pdcd1) antibody
  • CD279 antibody
  • hPD-1 antibody
  • hPD-l antibody
  • Ly101 antibody
  • PD-1 antibody
  • PD1 antibody
  • Pdc1 antibody
  • SLEB2 antibody

Protein level used designations for PDCD1

programmed cell death protein 1 , protein PD-1 , programmed cell death 1 , programmed death 1 , mPD-1

GENE ID SPECIES
5133 Homo sapiens
301626 Rattus norvegicus
424913 Gallus gallus
613842 Bos taurus
18566 Mus musculus
486213 Canis lupus familiaris
100135775 Macaca mulatta
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