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May have a role in the regulation of spermatogenesis.. Additionally we are shipping PD-1 Antibodies (611) and PD-1 Kits (18) and many more products for this protein.
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Human PD-1 Protein expressed in Wheat germ - ABIN1314407
Matsumoto, Miyake, Matsushita, Ohnishi, Ikeda, Shiraha, Takaki, Nouso, Yamamoto: Anti-programmed cell death-1 antibody as a new serological marker for type 1 autoimmune hepatitis. in Journal of gastroenterology and hepatology 2013
Show all 2 references for ABIN1314407
Mouse (Murine) PD-1 Protein expressed in Human Cells - ABIN2007359
Prodeus, Abdul-Wahid, Fischer, Huang, Cydzik, Gariépy: Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers. in Molecular therapy. Nucleic acids 2015
In diffuse large B-cell lymphoma, PD-1 was expressed in tumor-infiltrating lymphocytes of 39.5% patients. PD-L1 (show CD274 Proteins) was expressed in tumor cells of 26.3% patients, and TP63 (show TP63 Proteins) was in tumor cells of 31.6% cases. PD-1 expression was associated with the patients' gender and B symptoms. PD-1 in tumor-infiltrating lymphocytes was related to prolonged overall survival, but PD-L1 (show CD274 Proteins) expression was associated with worse clinical outcome.
PD-1 expression in chromophobe renal cell carcinoma (show MOK Proteins)
PD-1 and PD-L1 (show CD274 Proteins) expressions are up to 30 % of the cases with sarcomas. It may be rational to target programmed death pathway in Kaposi sarcoma, pleomorphic sarcoma and peripheral nerve sheath tumors. Strong expression of PD-1/PD-L1 (show CD274 Proteins) in cases with previous giant cell bone tumor has been found to be interesting and must be studied in giant cell tumor samples.
Elevated frequencies of CD8 (show CD8A Proteins) T cells expressing PD-1, CTLA-4 (show CTLA4 Proteins) and Tim-3 (show HAVCR2 Proteins) were found within tumor from perineural squamous cell carcinoma patients.
PD-1 and PD-L1 (show CD274 Proteins) protein expression and their correlation with tumor-in fi ltrating lymphocytes (TILs), and association with survival in non-small cell lung cancer, were examined.
We identify a novel protumorigenic PD-1(hi) B-cell subset in human HCC (show FAM126A Proteins) that exhibits a phenotype distinct from that of peripheral regulatory B cells. TLR4 (show TLR4 Proteins)-mediated BCL6 (show BCL6 Proteins) upregulation is critical for induction of PD-1(hi) B cells, which operate via IL10 (show IL10 Proteins)-dependent pathways upon interacting with PD-L1 (show CD274 Proteins) to cause T-cell dysfunction and foster disease progression.
over-expression of PD-1 in subsets of vascular anomalies, while PD-L1 (show CD274 Proteins) was negative
The results demonstrated significantly lower expression of PD-1 and PD-L1 (show CD274 Proteins) in chronic ITP (show ITPA Proteins) patients compared with healthy individuals.
Immune checkpoint proteins are co-inhibitory factors that can diminish the antigen-specific immune responses by attenuating the regulatory role of cytotoxic T-lymphocyte-associated protein 4 (show CTLA4 Proteins), programmed cell death-1, lymphocyte-activation gene 3 (show LAG3 Proteins), and T-cell immunoglobulin mucin-3 (show HAVCR2 Proteins)
PD-1 may play a key role in the process of carcinogenesis of ESCC but not associated with prognosis and overall survival.
These studies indicate that PD-1 is a critical homeostatic regulator for Tregs by modulating proliferation and apoptosis during IL-2 (show IL2 Proteins) therapy.
data defined PD-1(hi)IL-25R(hi) as an early checkpoint in Innate lymphoid cell development; results provide a perspective for exploring PD-1 and its ligand (PD-L1 (show CD274 Proteins)) in immunotherapy, and allow effective manipulation of the immune system for disease prevention and therapy
Authors demonstrate that inactivation of the PD-1 gene in melanoma-reactive CD8 (show CD8A Proteins)(+) T cells and in fibrosarcoma-reactive polyclonal T cells enhanced the persistence of PD-1 gene-modified T cells at the tumor site and increased tumor control.
PD-1/PD-L1 (show CD274 Proteins) plays a crucial role in maintaining immune tolerance induced by UVB-iDCs, as well as in actively controlling effector T cells specific to alloantigens.
PD-1 dampens antigen-specific Th17 response, thus inhibiting autoimmune arthritis
Tim-3 (show HAVCR2 Proteins)(+) PD-1(+) CD8 (show CD8A Proteins)(+) T cells showed more evident properties associated with exhaustion than Tim-3 (show HAVCR2 Proteins)(-) PD-1(+) CD8 (show CD8A Proteins)(+) T cells.
that porcine islet-specific tolerance is dependent on PD-1, which could not be extended to skin grafts
Programmed cell death-1 engagement followed by zymosan stimulation might primarily attenuate the phosphorylation of tyrosine residue in Programmed cell death-1 receptor/ligand.
Study suggests that expression of the inhibitory receptors PD-1 and LAG-3 (show LAG3 Proteins) on CD4 (show CD4 Proteins)(+) T cells and their reduced IL-2 (show IL2 Proteins) production are common characteristic features of Plasmodium infection.
these data suggest a scenario in which microglia are involved in the regulation of experimental autoimmune encephalomyelitis by suppressing Th1 (show HAND1 Proteins)-cell differentiation via the PD-L1 (show CD274 Proteins)-nitric oxide pathway.
May have a role in the regulation of spermatogenesis.
programmed cell death 1
, programmed cell death protein 1
, protein PD-1
, programmed death 1
, spermatogenesis associated PD1
, spermatogenesis-associated protein 2
, spermatogenesis-associated protein PD1