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May have a role in the regulation of spermatogenesis.. Additionally we are shipping PD-1 Antibodies (642) and PD-1 Kits (22) and many more products for this protein.
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Human PD-1 Protein expressed in Wheat germ - ABIN1314407
Matsumoto, Miyake, Matsushita, Ohnishi, Ikeda, Shiraha, Takaki, Nouso, Yamamoto: Anti-programmed cell death-1 antibody as a new serological marker for type 1 autoimmune hepatitis. in Journal of gastroenterology and hepatology 2013
Show all 2 references for 1314407
Mouse (Murine) PD-1 Protein expressed in Human Cells - ABIN2007359
Prodeus, Abdul-Wahid, Fischer, Huang, Cydzik, Gariépy: Targeting the PD-1/PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers. in Molecular therapy. Nucleic acids 2015
PD-1 is required for maintaining the number, and hence function, of KLRG1 (show KLRG1 Proteins)(+) Group 2 innate lymphoid cells.
In cutaneous diffuse large b-cell lymphoma, a considerable proportion of CD33 (show CD33 Proteins)(+) myeloid-derived suppressor cells (MDSCs) with PD-L1 (show CD274 Proteins) coexpression was admixed. Tumor cells expressed CD33 (show CD33 Proteins) to variable degrees (2% to 60%). We propose that PD-L1 (show CD274 Proteins)(+) tumor cells and PD-L1 (show CD274 Proteins)(+) MDSCs shield the tumor against PD-1(+) tumor-infiltrating lymphocytes, consequently leading to inhibition and diminution of tumor-infiltrating lymphocytes.
Autoimmune hepatitis (AIH) AIH patients with active disease and incomplete response to standard treatment have similarly increased sPD (show HOXD13 Proteins)-1 levels. AIH patients have increased ability to up-regulate PD-1 following in vitro activation.
All anaplastic thyroid cancer samples demonstrated PD-1 expression in inflammatory cells whereas tumor cells were primarily negative.
PD-1 and PD-L1 (show CD274 Proteins) are highly expressed by most small intestinal adenocarcinomas.
both mouse and human tumour-associated macrophages (TAM (show CCNA1 Proteins)) express PD-1; TAM (show CCNA1 Proteins) PD-1 expression increases over time in mouse models of cancer and with increasing disease stage in primary human cancers
The data reveal SPATA2 (show SPATA2 Proteins) as a high-affinity binding partner of CYLD (show CYLD Proteins) and HOIP (show RNF31 Proteins), and a regulatory component of linear ubiquitin chain assembly complex-mediated NF-kappaB (show NFKB1 Proteins) signaling.
This study shows that only PDCD1/rs2227981 contributes to the genetic susceptibility of SO, and that the other 23 susceptibility loci of VKH disease are probably not involved in the pathogenesis of this disease.
In sepsis, reducted neutrophil and monocyte function correlated with PD-1 expression on CD8 (show CD8A Proteins)(+) T cells and NK cells. Antibodies against PD-1 restored function in neutrophil, monocyte, T cells, and NK cells, showing the impact of the PD-1:PD-L1 (show CD274 Proteins) axis in sepsis-immune suppression.
PD-L1 (show CD274 Proteins)/PD-1 are expressed in neoplastic and nonneoplastic thymus and do not appear to modulate the presence of CD4 (show CD4 Proteins)/CD8 (show CD8A Proteins) positive lymphocytes.
this study shows that PD-1 regulates early glycolytic and mitochondrial alterations in virus-specific CD8+ T cells generated during infection, and represses transcriptional coactivator PGC-1alpha
Our results suggest that anti-PD-1 antibody treatment has little effect on afatinib-induced lung injury.
These data implicate a critical role for conserved region C (CR-C), a promoter proximal cis (show CISH Proteins)-regulatory element that is critical to PD-1 expression in vitro, in governing PD-1 expression, and a subsequent role in guiding CD8 (show CD8A Proteins) T cell differentiation
we provide evidence that indicates that the PD-1(+) fraction of DN T cells represents self-reactive cells.
PD-1 is overexpressed in IL-17A (show IL17A Proteins)-producing T cells in both imiquimod-treated mice and patients with psoriasis. Moreover, recombinant PD-L1 (show CD274 Proteins)-Fc alleviates psoriatic inflammation in imiquimod-treated mice.
PD-1 receptor has a role in interacting with programmed cell death ligands and B7-1 (show CD80 Proteins)
PD-1 is upregulated in CD4 (show CD4 Proteins)+ T cells in Schistosoma japonicum (S. japonicum)-infected mice.
Findings indicated that METH (show MTRR Proteins) induced the upregulation of PD-1 expression which altered the cytokine production as well as cytotoxic functions in mouse model of lymphocytic choriomeningitis virus infection.
May have a role in the regulation of spermatogenesis.
programmed cell death 1
, programmed cell death protein 1
, protein PD-1
, programmed death 1
, spermatogenesis associated PD1
, spermatogenesis-associated protein 2
, spermatogenesis-associated protein PD1