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PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Additionally we are shipping PDCD4 Kits (13) and PDCD4 Proteins (12) and many more products for this protein.
Showing 10 out of 235 products:
Human Polyclonal PDCD4 Primary Antibody for EIA, IHC (p) - ABIN500461
Göke, Barth, Schmidt, Samans, Lankat-Buttgereit: Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1). in American journal of physiology. Cell physiology 2004
Show all 4 references for ABIN500461
Cow (Bovine) Polyclonal PDCD4 Primary Antibody for WB - ABIN2792230
Yang, Cho, Zakowicz, Hegamyer, Sonenberg, Colburn: A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. in Molecular and cellular biology 2004
Show all 3 references for ABIN2792230
Human Monoclonal PDCD4 Primary Antibody for EIA, IHC (fro) - ABIN400797
Huang, Wu, Loeb, Hsu, Heidersbach, Brincat, Horiuchi, Lebbink, Mo, Goga, McManus: Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. in The Journal of biological chemistry 2009
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Human Monoclonal PDCD4 Primary Antibody for IHC, ELISA - ABIN1043755
Jansen, Camalier, Colburn: Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis. in Cancer research 2005
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Human Polyclonal PDCD4 Primary Antibody for IF, ELISA - ABIN1532754
Deloukas, Earthrowl, Grafham, Rubenfield, French, Steward, Sims, Jones, Searle, Scott, Howe, Hunt, Andrews, Gilbert, Swarbreck, Ashurst, Taylor, Battles, Bird, Ainscough, Almeida, Ashwell, Ambrose et al.: The DNA sequence and comparative analysis of human chromosome 10. ... in Nature 2004
Human Monoclonal PDCD4 Primary Antibody for EIA, IHC (p) - ABIN317548
Palamarchuk, Efanov, Maximov, Aqeilan, Croce, Pekarsky: Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. in Cancer research 2005
Human Polyclonal PDCD4 Primary Antibody for WB - ABIN2774608
Yang, Matthews, Clair, Wang, Baker, Li, Tan, Colburn: Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. in Molecular and cellular biology 2006
Human Polyclonal PDCD4 Primary Antibody for IHC (p), WB - ABIN657922
Hayashi, Aishima, Miyasaka, Nakata, Morimatsu, Oda, Nagai, Oda, Tanaka, Tsuneyoshi: Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas: its association with tumor progression and proliferation. in Human pathology 2010
PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6 (show IL6 Antibodies)/STAT3 (show STAT3 Antibodies) Pathway.
Study found that miR-16 (show GDE1 Antibodies) was the direct regulatory element of PDCD4 and played a vital role in atherosclerosis by regulating PDCD4 and the downstream NF-kappaB (show NFKB1 Antibodies) and MAPK (show MAPK1 Antibodies) pathways.
Pdcd4 produces unfavorable influences on adipose-derived stem cells(ADSC) stemness, which contribute to adipose dysfunction, obesity and metabolic syndromes, thereby proposing Pdcd4 as a potential intervening target for regulating ADSC cells function.
PDCD4 serves as an important regulator of keratinocytes proliferation and contact inhibition in vitro.
In conclusion, miR (show MLXIP Antibodies)-21 is sensitive to high-concentration glucose treatment in macrophages, and appears to have a protective effect in macrophage apoptosis induced by high concentrations of glucose via PDCD4.
atheroprotective unidirectional pulsatile shear stress affects the expression of PDCD4 in endothelial cells
we demonstrate that miR (show MLXIP Antibodies)-21 regulates T-cell acute lymphoblastic leukemia cell survival via repression of the tumor suppressor Pdcd4.
Dual expression of shAkt1 and Pdcd4 effectively suppresses lung tumorigenesis
miR (show MLXIP Antibodies)-21 is endowed with anti-apoptotic properties by suppressing the expression of PDCD4 gene and active caspase 3 (show CASP3 Antibodies)/8 fragments in the condition of renal IRI
sulforaphane protects PDCD4 downregulation posed by pro-inflammatory stimuli through modulating both transcription and proteolysis via controlling Akt1 (show AKT1 Antibodies) and/or S6K1 (show RPS6KB1 Antibodies) activities in RAW 264.7 cells
miR (show MLXIP Antibodies)-21 can confer drug resistance to 5-FU in pancreatic cancer cells by regulating the expression of tumor suppressor genes, as the target genes of miR (show MLXIP Antibodies)-21, PTEN (show PTEN Antibodies) and PDCD4 can rescue 5-FU sensitivity and the phenotypic characteristics disrupted by miR (show MLXIP Antibodies)-21.
In HeLa cells, phosphorylation of HuR (show ELAVL1 Antibodies) by ERK8 (show MAPK15 Antibodies) prevents it from binding to PDCD4 mRNA and allows miR (show MLXIP Antibodies)-21-mediated degradation of PDCD4.
miR (show MLXIP Antibodies)-183 maybe functions as an oncogene (show RAB1A Antibodies) by regulating gastric cancer cell proliferation, apoptosis and metastasis and the oncogenic effect of miR (show MLXIP Antibodies)-183 may relate the direct targeting PDCD4
PDCD4 inhibits cell growth through PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling in non-small cell lung cancer.
This study describes the regulation of PDCD4 specifically in tonsil SCC (show CYP11A1 Antibodies) by miR (show MLXIP Antibodies)-499 and miR (show MLXIP Antibodies)-21 and has documented the loss of PDCD4 in oropharyngeal squamous cell carcinoma
Unprecedentedly, HuR (show ELAVL1 Antibodies) was also found to bind to miR (show MLXIP Antibodies)-21 directly, preventing its interaction with the PDCD4 3'-UTR (show UTS2R Antibodies), thereby preventing the translation repression of PDCD4.
miR (show MLXIP Antibodies)-21 has a role in upregulating PTEN (show PTEN Antibodies), RECK (show RECK Antibodies) and PDCD4 in glioma
PDGF (show PDGFA Antibodies)-BB stimulates cell proliferation through microRNA-21-mediated PDCD4 down-regulation, leading to the development of TAO.
Results indicated that PDCD4 may be a novel candidate of tumor suppressor gene in hepatocellular carcinoma and that promoter hypermethylation is an important mechanism for its downregulation and a good predictor of survival.
These findings suggest that miR (show MLXIP Antibodies)-21 and PDCD4 might be potential biomarkers for malignant melanoma and might provide treatment targets in the future.
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.
programmed cell death 4 (neoplastic transformation inhibitor)
, programmed cell death protein 4
, programmed cell death protein 4-like
, protein MA-3
, topoisomerase-inhibitor suppressed protein
, death up-regulated gene protein
, neoplastic transformation inhibitor protein
, nuclear antigen H731
, protein 197/15a
, protein I11/6