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PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Additionally we are shipping PDCD4 Kits (14) and PDCD4 Proteins (12) and many more products for this protein.
Showing 10 out of 242 products:
Human Polyclonal PDCD4 Primary Antibody for EIA, IHC (p) - ABIN500461
Göke, Barth, Schmidt, Samans, Lankat-Buttgereit: Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1). in American journal of physiology. Cell physiology 2004
Show all 4 references for ABIN500461
Cow (Bovine) Polyclonal PDCD4 Primary Antibody for WB - ABIN2792230
Yang, Cho, Zakowicz, Hegamyer, Sonenberg, Colburn: A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. in Molecular and cellular biology 2004
Show all 3 references for ABIN2792230
Human Monoclonal PDCD4 Primary Antibody for IHC, ELISA - ABIN1043755
Jansen, Camalier, Colburn: Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis. in Cancer research 2005
Show all 2 references for ABIN1043755
Human Monoclonal PDCD4 Primary Antibody for ELISA, WB - ABIN316114
Abraham, Jackson, Gundara, Zhao, Gill, Delbridge, Robinson, Sidhu: MicroRNA profiling of sporadic and hereditary medullary thyroid cancer identifies predictors of nodal metastasis, prognosis, and potential therapeutic targets. in Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Human Polyclonal PDCD4 Primary Antibody for IF, ELISA - ABIN1532754
Deloukas, Earthrowl, Grafham, Rubenfield, French, Steward, Sims, Jones, Searle, Scott, Howe, Hunt, Andrews, Gilbert, Swarbreck, Ashurst, Taylor, Battles, Bird, Ainscough, Almeida, Ashwell, Ambrose et al.: The DNA sequence and comparative analysis of human chromosome 10. ... in Nature 2004
Human Monoclonal PDCD4 Primary Antibody for EIA, IHC (p) - ABIN317548
Palamarchuk, Efanov, Maximov, Aqeilan, Croce, Pekarsky: Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. in Cancer research 2005
Human Polyclonal PDCD4 Primary Antibody for WB - ABIN2774608
Yang, Matthews, Clair, Wang, Baker, Li, Tan, Colburn: Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. in Molecular and cellular biology 2006
Human Polyclonal PDCD4 Primary Antibody for IHC (p), WB - ABIN657922
Hayashi, Aishima, Miyasaka, Nakata, Morimatsu, Oda, Nagai, Oda, Tanaka, Tsuneyoshi: Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas: its association with tumor progression and proliferation. in Human pathology 2010
PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6 (show IL6 Antibodies)/STAT3 (show STAT3 Antibodies) Pathway.
Study found that miR-16 (show GDE1 Antibodies) was the direct regulatory element of PDCD4 and played a vital role in atherosclerosis by regulating PDCD4 and the downstream NF-kappaB (show NFKB1 Antibodies) and MAPK (show MAPK1 Antibodies) pathways.
Pdcd4 produces unfavorable influences on adipose-derived stem cells(ADSC) stemness, which contribute to adipose dysfunction, obesity and metabolic syndromes, thereby proposing Pdcd4 as a potential intervening target for regulating ADSC cells function.
PDCD4 serves as an important regulator of keratinocytes proliferation and contact inhibition in vitro.
In conclusion, miR (show MLXIP Antibodies)-21 is sensitive to high-concentration glucose treatment in macrophages, and appears to have a protective effect in macrophage apoptosis induced by high concentrations of glucose via PDCD4.
atheroprotective unidirectional pulsatile shear stress affects the expression of PDCD4 in endothelial cells
we demonstrate that miR (show MLXIP Antibodies)-21 regulates T-cell acute lymphoblastic leukemia cell survival via repression of the tumor suppressor Pdcd4.
Dual expression of shAkt1 and Pdcd4 effectively suppresses lung tumorigenesis
miR (show MLXIP Antibodies)-21 is endowed with anti-apoptotic properties by suppressing the expression of PDCD4 gene and active caspase 3 (show CASP3 Antibodies)/8 fragments in the condition of renal IRI
sulforaphane protects PDCD4 downregulation posed by pro-inflammatory stimuli through modulating both transcription and proteolysis via controlling Akt1 (show AKT1 Antibodies) and/or S6K1 (show RPS6KB1 Antibodies) activities in RAW 264.7 cells
Data indicate that programmed cell death 4 (PDCD4) was identified to be a target of ubiquitin-specific protease 4 (USP4 (show USP4 Antibodies)), which plays a role as a tumor suppressor.
PDCD4 down-regulation is involved in the progression of several types of solid tumor.
Results show that exosome-shuttling miR (show MLXIP Antibodies)-21 represses PDCD4 protein expression by binding to 3'-UTR (show UTS2R Antibodies) in esophageal cancer cells.
miR (show MLXIP Antibodies)-21, acting on PDCD4, which interacts with Twist1 (show TWIST1 Antibodies) and represses the expression of Twist1 (show TWIST1 Antibodies), contributes to the EMT (show ITK Antibodies) induced by arsenite in transformed bronchial epithelial cells.
Data show that microRNA miR (show MLXIP Antibodies)-93 directly binds to the 3' untranslated regions (3'-UTR (show UTS2R Antibodies)) of the programmed cell death 4 (PDCD4) mRNA transcript and inhibits PDCD4 translation in gastric cancer cells
miR (show MLXIP Antibodies)-21 can confer drug resistance to 5-FU in pancreatic cancer cells by regulating the expression of tumor suppressor genes, as the target genes of miR (show MLXIP Antibodies)-21, PTEN (show PTEN Antibodies) and PDCD4 can rescue 5-FU sensitivity and the phenotypic characteristics disrupted by miR (show MLXIP Antibodies)-21.
In HeLa cells, phosphorylation of HuR (show ELAVL1 Antibodies) by ERK8 (show MAPK15 Antibodies) prevents it from binding to PDCD4 mRNA and allows miR (show MLXIP Antibodies)-21-mediated degradation of PDCD4.
miR (show MLXIP Antibodies)-183 maybe functions as an oncogene (show RAB1A Antibodies) by regulating gastric cancer cell proliferation, apoptosis and metastasis and the oncogenic effect of miR (show MLXIP Antibodies)-183 may relate the direct targeting PDCD4
PDCD4 inhibits cell growth through PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling in non-small cell lung cancer.
This study describes the regulation of PDCD4 specifically in tonsil SCC (show CYP11A1 Antibodies) by miR (show MLXIP Antibodies)-499 and miR (show MLXIP Antibodies)-21 and has documented the loss of PDCD4 in oropharyngeal squamous cell carcinoma
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.
programmed cell death 4 (neoplastic transformation inhibitor)
, programmed cell death protein 4
, programmed cell death protein 4-like
, protein MA-3
, topoisomerase-inhibitor suppressed protein
, death up-regulated gene protein
, neoplastic transformation inhibitor protein
, nuclear antigen H731
, protein 197/15a
, protein I11/6