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Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) Proteins (PDCD4)

PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Additionally we are shipping PDCD4 Antibodies (241) and PDCD4 Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PDCD4 18569 Q61823
PDCD4 64031 Q9JID1
PDCD4 27250 Q53EL6
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Top PDCD4 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
$7,759.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated Figure annotation denotes ug of protein loaded and % gel used. 100 μg Log in to see 7 to 9 Days
$364.64
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$385.00
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 11 Days
$225.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,314.67
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$3,322.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,322.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   1 mg Log in to see 3 to 4 Days
$5,769.50
Details

PDCD4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , ,
,

More Proteins for Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Interaction Partners

Mouse (Murine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) Pathway.

  2. Study found that miR-16 (show GDE1 Proteins) was the direct regulatory element of PDCD4 and played a vital role in atherosclerosis by regulating PDCD4 and the downstream NF-kappaB (show NFKB1 Proteins) and MAPK (show MAPK1 Proteins) pathways.

  3. Pdcd4 produces unfavorable influences on adipose-derived stem cells(ADSC) stemness, which contribute to adipose dysfunction, obesity and metabolic syndromes, thereby proposing Pdcd4 as a potential intervening target for regulating ADSC cells function.

  4. PDCD4 serves as an important regulator of keratinocytes proliferation and contact inhibition in vitro.

  5. In conclusion, miR (show MLXIP Proteins)-21 is sensitive to high-concentration glucose treatment in macrophages, and appears to have a protective effect in macrophage apoptosis induced by high concentrations of glucose via PDCD4.

  6. atheroprotective unidirectional pulsatile shear stress affects the expression of PDCD4 in endothelial cells

  7. we demonstrate that miR (show MLXIP Proteins)-21 regulates T-cell acute lymphoblastic leukemia cell survival via repression of the tumor suppressor Pdcd4.

  8. Dual expression of shAkt1 and Pdcd4 effectively suppresses lung tumorigenesis

  9. miR (show MLXIP Proteins)-21 is endowed with anti-apoptotic properties by suppressing the expression of PDCD4 gene and active caspase 3 (show CASP3 Proteins)/8 fragments in the condition of renal IRI

  10. sulforaphane protects PDCD4 downregulation posed by pro-inflammatory stimuli through modulating both transcription and proteolysis via controlling Akt1 (show AKT1 Proteins) and/or S6K1 (show RPS6KB1 Proteins) activities in RAW 264.7 cells

Human Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) interaction partners

  1. The expression of miR (show MLXIP Proteins)-21 and PDCD4 at messenger RNA level was evaluated by quantitative real-time polymerase chain reaction, while the protein level of PDCD4 was determined by Western blotting. Authors found that locked nucleic acid-anti-miR (show MLXIP Proteins)-21 transfection was associated with a significant reduction in metastatic properties as assessed by the in ovo model.

  2. Data indicate that programmed cell death 4 (PDCD4) was identified to be a target of ubiquitin-specific protease 4 (USP4 (show USP4 Proteins)), which plays a role as a tumor suppressor.

  3. PDCD4 down-regulation is involved in the progression of several types of solid tumor.

  4. Results show that exosome-shuttling miR-21 represses PDCD4 protein expression by binding to 3'-UTR in esophageal cancer cells.

  5. miR (show MLXIP Proteins)-21, acting on PDCD4, which interacts with Twist1 (show TWIST1 Proteins) and represses the expression of Twist1 (show TWIST1 Proteins), contributes to the EMT (show ITK Proteins) induced by arsenite in transformed bronchial epithelial cells.

  6. Data show that microRNA miR (show MLXIP Proteins)-93 directly binds to the 3' untranslated regions (3'-UTR) of the programmed cell death 4 (PDCD4) mRNA transcript and inhibits PDCD4 translation in gastric cancer cells

  7. miR (show MLXIP Proteins)-21 can confer drug resistance to 5-FU in pancreatic cancer cells by regulating the expression of tumor suppressor genes, as the target genes of miR (show MLXIP Proteins)-21, PTEN and PDCD4 can rescue 5-FU sensitivity and the phenotypic characteristics disrupted by miR (show MLXIP Proteins)-21.

  8. In HeLa cells, phosphorylation of HuR (show ELAVL1 Proteins) by ERK8 (show MAPK15 Proteins) prevents it from binding to PDCD4 mRNA and allows miR (show MLXIP Proteins)-21-mediated degradation of PDCD4.

  9. miR (show MLXIP Proteins)-183 maybe functions as an oncogene (show RAB1A Proteins) by regulating gastric cancer cell proliferation, apoptosis and metastasis and the oncogenic effect of miR (show MLXIP Proteins)-183 may relate the direct targeting PDCD4

  10. PDCD4 inhibits cell growth through PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling in non-small cell lung cancer.

PDCD4 Protein Profile

Protein Summary

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PDCD4

  • programmed cell death 4 (neoplastic transformation inhibitor) (pdcd4)
  • programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4)
  • programmed cell death 4 (Pdcd4)
  • D19Ucla1 protein
  • Dug protein
  • H731 protein
  • Ma3 protein
  • MGC69337 protein
  • PDCD4 protein
  • Tis protein

Protein level used designations for PDCD4

programmed cell death 4 (neoplastic transformation inhibitor) , programmed cell death protein 4 , programmed cell death protein 4-like , protein MA-3 , topoisomerase-inhibitor suppressed protein , death up-regulated gene protein , death-upregulated , neoplastic transformation inhibitor protein , nuclear antigen H731 , protein 197/15a , protein I11/6

GENE ID SPECIES
407925 Xenopus (Silurana) tropicalis
450735 Pan troglodytes
695345 Macaca mulatta
100021762 Monodelphis domestica
100080517 Ornithorhynchus anatinus
100354557 Oryctolagus cuniculus
100413000 Callithrix jacchus
100469480 Ailuropoda melanoleuca
100584426 Nomascus leucogenys
18569 Mus musculus
64031 Rattus norvegicus
27250 Homo sapiens
380222 Xenopus laevis
374191 Gallus gallus
477818 Canis lupus familiaris
506724 Bos taurus
100157112 Sus scrofa
100173014 Pongo abelii
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