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PDCD5 encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. Additionally we are shipping PDCD5 Antibodies (68) and PDCD5 Proteins (16) and many more products for this protein.
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Human PDCD5 ELISA Kit for Sandwich ELISA - ABIN1117839
Fu, Cheng, He, Liu, Liu: PDCD5 expression predicts a favorable outcome in patients with hepatocellular carcinoma. in International journal of oncology 2013
Show all 3 references for ABIN1117839
Endogenous PDCD5 overexpression accelerated multiple myeloma cell apoptosis under dexamethasone treatment.
Studies indicate that programmed cell death 5 (PDCD5) interacts with the tumor protein p53 (p53 (show TP53 ELISA Kits)) pathway to promote cell apoptosis.
This review describes what is known about PDCD5 and its cellular functions. [review]
The results suggest a role of PDCD5 in the regulation of p53 (show TP53 ELISA Kits) function but unrelated to cell cycle arrest or apoptosis, at least in the cell types investigated.
PDCD5 selectively mediates HDAC3 (show HDAC3 ELISA Kits) dissociation from p53 (show TP53 ELISA Kits), which induces HDAC3 (show HDAC3 ELISA Kits) cleavage and ubiquitin-dependent proteasomal degradation. This is a a mechanism for p53 (show TP53 ELISA Kits) activation via PDCD5-dependent HDAC3 (show HDAC3 ELISA Kits) decay under genotoxic stress conditions.
PDCD5 expression is negatively correlated with disease progression and stage in ovarian cancer.
These findings uncovered an apoptotic signaling cascade linking YAF2 (show YAF2 ELISA Kits), PDCD5, and TP53 (show TP53 ELISA Kits) during genotoxic stress responses.
Transgenic mice with systemic overexpression of human PDCD5 were protected from cardiac remodeling.
Findings have uncovered an apoptotic signaling cascade linking PDCD5, OTUD5 (show OTUD5 ELISA Kits), and p53 (show TP53 ELISA Kits) during genotoxic stress responses.
Authors identified DNAJB1 (show DNAJB1 ELISA Kits) as a negative regulator of PDCD5-mediated apoptosis and found that the apoptosis network of PDCD5 regulates cancer cell death.
It is implied that overexpression of PDCD5 causes the increase in caspase-3 (show CASP3 ELISA Kits) activity and the subsequent increase of apoptosis in cochlear hair cells and SGNs, and thereby plays a role in the pathogenesis of presbycusis.
PDCD5 activity in T cells suppresses autoimmunity by modulating regulatory T-cells.
The expression levels of PDCD5 and caspase 3 (show CASP3 ELISA Kits) in the cochlea of C57 mice increase with age.
Suppresses the pathogenicity of transplanted mouse erythroleukemia (MEL (show RAB8A ELISA Kits)) cells in mice.
This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12
programmed cell death protein 5
, programmed cell death 5
, hypothetical protein
, TF-1 cell apoptosis-related protein 19
, TF1 cell apoptosis-related gene 19
, TFAR19 novel apoptosis-related
, TF-1 cell apoptosis related gene-19 protein