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PDCD6 encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Additionally we are shipping PDCD6 Antibodies (82) and PDCD6 Proteins (14) and many more products for this protein.
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Our results suggest that PDCD6 may play an important role in the pathogenesis of cervical squamous cell carcinoma
PDCD6 may represent a biomarker candidate gene that could help to identify a group of patients at high risk for recurrence and death.
Palmitoylation sites and the N-terminal Pro-rich region were necessary for efficient secretion, but ABSs (ALG-2-binding sites) were dispensable.
The present study provided evidence that rs4957014 and rs3756712 are associated with Uterine leiomyoma (UL) risk, the results indicated that genetic polymorphisms in PDCD6 may contribute to the development of UL.
CHERP and ALG-2 participate in regulation of alternative splicing of IP3R1 (show ITPR1 ELISA Kits) pre-mRNA and provide new insights into post-transcriptional regulation of splicing variants in Ca(2 (show CA2 ELISA Kits)+) signaling pathways.
the binding of ALG-2 to IST1 (show IST1 ELISA Kits) is Ca(2 (show CA2 ELISA Kits)+)-dependent
the current study indicates that PDCD6 gene may be a new susceptibility gene to endometriosis.
The results of this study show that rs4957014G/T is associated with an increased risk of non-small cell lung cancer (NSCLC), which suggest that PDCD6 gene single nucleotide polymorphism is a risk factor for susceptibility of NSCLC.
we conclude that a novel p53 (show TP53 ELISA Kits)-responsive gene PDCD6 is accumulated in the nucleus and induces apoptosis in response to DNA damage.
PDCD6 seems to play an important role in ovarian cancer progression.
Substitution of either L52 with Ala or F148 with Ser (show SIGLEC1 ELISA Kits) of ALG-2 caused loss of binding abilities to PLSCR3 (show PLSCR3 ELISA Kits) lacking type 1 motif but retained those to PLSCR3 (show PLSCR3 ELISA Kits) lacking type 2 motif
ALG-2 is physiologically dispensable for apoptotic responses (ALG-2 protein)
This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5.
programmed cell death 6
, programmed cell death protein 6
, apoptosis-linked gene 2 protein
, probable calcium-binding protein ALG-2