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Proline Rich Membrane Anchor 1 Proteins (PRIMA1)

The product of PRIMA1 functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes.

list all proteins Gene Name GeneID UniProt
PRIMA1 145270 Q86XR5
PRIMA1 170952 Q810F0
PRIMA1 690195 D3ZZP4
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Top PRIMA1 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days

PRIMA1 Proteins by Origin and Source

Origin Expressed in Conjugate

Mouse (Murine)

Rat (Rattus)

More Proteins for Proline Rich Membrane Anchor 1 (PRIMA1) Interaction Partners

Human Proline Rich Membrane Anchor 1 (PRIMA1) interaction partners

  1. Hypermethylation of the selected markers (MAL (show MAL Proteins), PRIMA1, PTGDR (show PTGDR Proteins) and SFRP1 (show SFRP1 Proteins)) can result in reduced gene expression and may contribute to the formation of colorectal cancer.

  2. The autophagic potential of PRIMA-1 could be modulated in a different way by the presence of wild type or mutant p53 (show TP53 Proteins).

  3. By using site-directed mutagenesis, the asparagine-43 was identified to be the N-linked glycosylation site of PRiMA. Abolishing glycosylation on mouse PRiMA appeared not to affect its assembly with AChE(T).

  4. A strong association of AChE with PRiMA at the plasma membrane is therefore a feature specific to principal cholinergic neurons that innervate the central nervous system.

  5. PRiMA in neurons has a role in targeting acetylcholinesterase (show AChE Proteins) to membrane rafts

  6. PRiMA-Luc promotor-driven luciferase activity was increased during cell differentiation

  7. These results suggested that a MAP kinase (show MAPK1 Proteins) signaling pathway served as one of the transcriptional regulators in controlling PRiMA gene expression during the neuronal differentiation process.

Mouse (Murine) Proline Rich Membrane Anchor 1 (PRIMA1) interaction partners

  1. It interacts with PS1 (show PSEN1 Proteins) and undergoes proteolytic processing.

  2. Elevated expression of muscarinic receptors is responsible for physiological adaptation of PRiMA-deficient developing mice.

  3. the relative content of AChE, BuChE and PRiMA mRNAs were compared in normal and Lama2dy muscle and sciatic nerve

  4. Data show that along the nerve terminus the vast majority of acetylcholinesterase (show AChE Proteins) is anchored by collagen Q that is only produced by the muscle, whereas very minor amounts of AChE are anchored by PRiMA that is produced by motoneurons.

  5. PRiMA expression is predominantly to the cholinergic system and that anchoring of cholinesterases to cell membranes by PRiMA represents a limiting factor for production of the AChE tailed splice variant (AChET)-PRiMA complex.

  6. A peptidic motif of PRiMA1 is defined which is nearly as efficient as the complete extracellular domain of PRiMA for recruitment of acetylcholinesterase (show AChE Proteins) subunits into secreted heteromeric complexes.

  7. expression of PRiMA, as well as PRiMA-associated G(4) AChE, in muscle is suppressed by muscle regulatory factors, muscular activity, and nerve-derived trophic factors

  8. Acetylcholinesterase (show AChE Proteins) associates differently with its anchoring proteins ColQ and PRiMA

  9. PRIMA-1MET targets mouse tumors carrying mutant p53 (show TP53 Proteins)

  10. Proline-rich membrane anchor protein (show CELSR3 Proteins) is necessary to target and/or to stabilize nascent acetylcholinesterase (show AChE Proteins) in neurons.

PRIMA1 Protein Profile

Protein Summary

The product of this gene functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes.

Gene names and symbols associated with PRIMA1

  • proline rich membrane anchor 1 (PRIMA1)
  • proline rich membrane anchor 1 (Prima1)
  • B230212M13Rik protein
  • BB120497 protein
  • PRiMA protein
  • Prima1l protein

Protein level used designations for PRIMA1

acetylcholinesterase membrane anchor precursor PRiMA , proline-rich membrane anchor 1 , acetylcholinesterase membrane anchor , proline rich membrane anchor 1-like

145270 Homo sapiens
170952 Mus musculus
690195 Rattus norvegicus
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