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The product of P4HTM belongs to the family of prolyl 4-hydroxylases. Additionally we are shipping Prolyl 4-Hydroxylase, Transmembrane (Endoplasmic Reticulum) Antibodies (67) and many more products for this protein.
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This review will expand our knowledge of biology of HIFs, PHDs, PHD (show PDC Proteins) inhibitors, and bone regeneration, and it may also aid the design of novel therapies for accelerating bone repair and regeneration or inhibiting bone tumours. [review]
Data suggest that PH-4 is a novel hypoxia-inducible factor-prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia.
This review summarizes recent progress in elucidating the molecular mechanisms of hypoxia-inducible factor (HIF)-1 (show HIF1A Proteins) activation, focusing on the role of oxygen-dependent asparaginyl hydroxylase in hypoxia signal transduction.
Results show that P4h-tm is expressed to a high degree in the mouse retinal pigment epithelium (RPE (show RPE Proteins)) and brain. P4h-tm-/- mice develop age-related renal dysfunction, resulting in proteinuria and impaired RPE (show RPE Proteins) functions, which eventually lead to an AMD (show AMD1 Proteins)-like pathology.
Adiponectin (show ADIPOQ Proteins) increases collagen production by inducing the expression of P4H, which may play a major role in the development of the thick fibrous cap of advanced atherosclerotic plaque
chronic stabilization of Hif-1alpha (show HIF1A Proteins) and Hif-2alpha (show EPAS1 Proteins) by genetic knockdown of Hif-p4h-2 (show EGLN1 Proteins) promotes cardioprotection by induction of many genes involved in glucose metabolism, cardiac function, and blood pressure.
The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified.
hypoxia-inducible factor prolyl 4-hydroxylase
, transmembrane prolyl 4-hydroxylase
, HIF-prolyl hydroxylase 4
, P4H with transmembrane domain
, Prolyl hydroxlase domain-containing 4
, hypoxia inducible factor prolyl 4 hydroxylase
, hypoxia-inducible factor prolyl hydroxylase 4
, proline 4-hydroxylase