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The protein encoded by PREP is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Additionally we are shipping Prolyl Endopeptidase Antibodies (63) and Prolyl Endopeptidase Proteins (8) and many more products for this protein.
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These findings provide evidence for newly-discovered roles for PREP in mechanisms regulating cellular plasticity through NCAM (show NCAM1 ELISA Kits) and PSA (show PLAG1 ELISA Kits)-NCAM (show NCAM1 ELISA Kits).
Study shows that the expression of POP increases with hepatocyte steatosis suggesting an important role in hepatocytes steatosis and possibly NAFLD (show TSC2 ELISA Kits).
It was found that human PREP behaves identically to the porcine homolog, displaying a double bell-shaped pH profile and a pH-dependent solvent kinetic isotope effect of the kcat/Km, features that set it apart from the related exopeptidase dipeptidyl peptidase IV (DPP IV (show DPP4 ELISA Kits)).
TLR4 (show TLR4 ELISA Kits) activation releases prolyl endopeptidase containing exosomes from airway epithelial cells.
This study found that circulating PREP activity was substantially reduced in all cirrhotic patients but those changes did not have evident correlation to hepatic encephalopathy.
PEP was significantly and positively associated with delinquent, aggressive, externalizing and internalizing behavior subscales.
PREP redox inactivation is due to oxidation of cysteine residues and consequent oligomerization through intermolecular disulfide bonds.
Data indicate that SAXS analysis showed that presequence protease (hPreP) open states and substrate binding dynamics.
The determination of PEP (show PAEP ELISA Kits) activity in the plasma may be a safe, minimally invasive and inexpensive way to define the aggressiveness of CRC (show CALR ELISA Kits) in daily practice.
first demonstration of colocalization of PREP and pathological proteins in the human brain, supporting the view that, at least in spatial terms, PREP could be associated with pathogenesis of neurodegenerative diseases
Molecular modeling and docking based approaches were used to unravel questions like differences in ligand binding affinities in three POP species (porcine, human and A. thaliana).
the expression of prolyl endopeptidase could be necessary for a correct reproductive function
As PREP inhibition also enhances autophagic clearance of aSyn, PREP inhibitors may reduce accumulation of aSyn inclusions via a dual mechanism and are thus a novel therapeutic candidate for synucleinopathies.
lncPrep+96kb could play a role in the POP gene activation in the granulosa cell.
PREP knockdown mice (Prep(gt/gt (show FABP6 ELISA Kits))) exhibited glucose intolerance, decreased fasting insulin (show INS ELISA Kits), increased fasting glucagon (show GCG ELISA Kits) levels, and reduced glucose-induced insulin (show INS ELISA Kits) secretion compared with wild-type controls.
The study reveals a role for prolyl endopeptidase in mediating hippocampal plasticity and spatial memory formation.
The POP promoter was sufficient for the appropriate localization in the placenta if it was not subject to position effect.
the cytoplasmic and membrane-associated POP have distinct roles in different types of placental cells.
alpha-MSH(1-13) is an in vivo substrate of PREP.
Cigarette smoke-induced lung emphysema is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown.
The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides.
, Prolyl endopeptidase
, dJ355L5.1 (prolyl endopeptidase)
, post-proline cleaving enzyme
, prolyl oligopeptidase