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The protein encoded by PREPL belongs to the prolyl oligopeptidase subfamily of serine peptidases. Additionally we are shipping Prolyl Endopeptidase Like Protein Kits (4) and Prolyl Endopeptidase Like Protein Proteins (4) and many more products for this protein.
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Deletion of PREPL is associated with Hypotonia-cystinuria syndrome.
Two novel deletions encompassing the SLC3A1 (show SLC3A1 Antibodies) and PREPL genes have been identified in unrelated hypotonia-cystinuria syndrome patients.
A 638-residue variant of PREPL, PREPL A, was identifiied, expressed in Escherichia coli and purified; its secondary structure was similar to that of oligopeptidase B.
Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome.
Deletion of the gene results in hypotonia at birth, failure to thrive and growth hormone (show GH1 PLURAL_@26348@) deficiency
a deletion of PREPL causes atypical hypotonia-cystinuria syndrome
Two key transcription factors, NRF-2 (show GABPA Antibodies) and YY-1 (show YY1 Antibodies), were further identified to coordinately participate in driving gene expressions of PREPL-C2ORF34 (show CAMKMT Antibodies) genes pairin an additive manner.
The data demonstrate PREPL as an AP-1 (show JUN Antibodies) effector that takes part in the regulation of AP-1 (show JUN Antibodies) membrane binding. PREPL is highly expressed in brain and at lower levels in muscle and kidney.
The protein encoded by this gene belongs to the prolyl oligopeptidase subfamily of serine peptidases. Mutations in this gene have been associated with hypotonia-cystinuria syndrome, also known as the 2p21 deletion syndrome. Several alternatively spliced transcript variants encoding either the same or different isoforms have been described for this gene.
putative prolyl oligopeptidase