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Prolylcarboxypeptidase Proteins (PRCP)

The protein encoded by PRCP is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. Additionally we are shipping Prolylcarboxypeptidase Antibodies (63) and Prolylcarboxypeptidase Kits (43) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PRCP 649 P13497
PRCP 72461 Q7TMR0
PRCP 293118  
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Top Prolylcarboxypeptidase Proteins at antibodies-online.com

Showing 9 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$827.20
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,268.83
Details
HOST_Human Human His tag   10 μg Log in to see 5 Days
$203.50
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$999.22
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details

PRCP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Prolylcarboxypeptidase (PRCP) Interaction Partners

Human Prolylcarboxypeptidase (PRCP) interaction partners

  1. Studies indicate crosstalk between Notch receptor and Wnt protein, Hedgehog protein, hypoxia and transforming growth factor beta (TGFbeta)/bone morphogenetic protein (BMP) pathways.

  2. study thus highlights the severe and progressive nature of BMP1 (show BMP1 Proteins)-associated OI in adults and broadens insights into the functional consequences of BMP1/mTLD-deficiency on ECM (show MMRN1 Proteins) organization.

  3. Data indicate that BMP-1 (show BMP1 Proteins) can simultaneously trigger matrix assembly and boost the synthesis of matrix proteins via a direct effect on growth factors in the contexts of development, growth and tissue repair. [review]

  4. The decrease in PRCP levels in the first 24 h after stroke onset is associated with stroke severity and an unfavourable short-term stroke outcome

  5. Two novel variants in the BMP1 (show BMP1 Proteins) gene: c.808A>G and c.1297G>T care associated with osteogenesis imperfecta (show COL1A2 Proteins).

  6. Frequent bone fracture in children is cause by BMP1 (show BMP1 Proteins)-1 deficiency.

  7. mutations of the DSP-PP P4 to P4' cleavage site can block, impair or accelerate dentin sialoprotein phosphophoryn cleavage, and suggest that its Bone morphogenic protein 1 cleavage site is conserved in order to regulate its cleavage efficiency

  8. PRCP1 interacts with plasma kallikrein (show KLKB1 Proteins) (PK) at multiple sites for PK activation.

  9. High BMP1 (show BMP1 Proteins) expression is associated with type-1 diabetes.

  10. Loss of bone morphogenetic protein is associated with prostate cancer.

Mouse (Murine) Prolylcarboxypeptidase (PRCP) interaction partners

  1. This study demonistrated that PRCP gene is broadly expressed in the brain.

  2. PRCP regulates cell growth, angiogenesis, and the response to vascular injury

  3. ACE2 (show ACE2 Proteins) metabolizes ANG II (show AGT Proteins) in the kidney at neutral and basic pH, while prolylcarboxypeptidase catalyzes the same reaction at acidic pH.

  4. PRCP is an important regulator of energy and glucose homeostasis since its deletion significantly improves metabolic parameters in mice exposed to both standard chow diet and high-fat diet

  5. analysis of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors

  6. This study showed that PRCP mutant mice have a significant decrease in fat mass, although an increase in lean mass was also observed; reduced leptin (show LEP Proteins) levels and increased energy expenditure were also found.

  7. Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis.

  8. PRCP is an important component of melanocortin signaling and weight maintenance via control of active alpha-MSH1-13 levels.

Prolylcarboxypeptidase (PRCP) Protein Profile

Protein Summary

The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene names and symbols associated with Prolylcarboxypeptidase Proteins (PRCP)

  • prolylcarboxypeptidase (angiotensinase C) (PRCP)
  • prolylcarboxypeptidase (angiotensinase C) (prcp)
  • prolylcarboxypeptidase (AaeL_AAEL005521)
  • prolylcarboxypeptidase (CpipJ_CPIJ006123)
  • prolylcarboxypeptidase (CpipJ_CPIJ006124)
  • bone morphogenetic protein 1 (BMP1)
  • prolylcarboxypeptidase (angiotensinase C) (Prcp)
  • 2510048K03Rik protein
  • 2610104A14Rik protein
  • AI451719 protein
  • HUMPCP protein
  • MGC145178 protein
  • OI13 protein
  • PCOLC protein
  • PCP protein
  • PCP2 protein
  • TLD protein

Protein level used designations for Prolylcarboxypeptidase Proteins (PRCP)

prolylcarboxypeptidase , mammalian tolloid protein , procollagen C-endopeptidase , procollagen C-proteinase , lysosomal Pro-X carboxypeptidase , proline carboxypeptidase , angiotensinase C , lysosomal carboxypeptidase C , prolylcarboxypeptidase isoform 1 preproprotein

GENE ID SPECIES
100061830 Equus caballus
780095 Xenopus (Silurana) tropicalis
5579822 Aedes aegypti
6038068 Culex quinquefasciatus
6038069 Culex quinquefasciatus
649 Homo sapiens
72461 Mus musculus
5547 Homo sapiens
476788 Canis lupus familiaris
534927 Bos taurus
293118 Rattus norvegicus
100734342 Cavia porcellus
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