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anti-Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) Antibodies

The protein encoded by PCSK1 belongs to the subtilisin-like proprotein convertase family. Additionally we are shipping PCSK1 Proteins (7) and PCSK1 Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PCSK1 5122 P29120
PCSK1 25204 P28840
PCSK1 18548 P63239
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Top anti-PCSK1 Antibodies at antibodies-online.com

Showing 10 out of 30 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Immunohistochemistry with Pancreas tissue at an antibody concentration of 5µg/ml using anti-PCSK1 antibody (ARP33848_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to PCSK1 on HeLa cell (antibody concentration 30 µg/mL). PCSK1 monoclonal antibody (M02), clone 3D2 Western Blot analysis of PCSK1 expression in HeLa. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated EIA, IF, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$566.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-PC1/3 antibody, Western blotting Lane 1: Rat Liver Tissue Lysate Lane 2: Rat Thymus Tissue Lysate Lane 3: A549 Cell Lysate Lane 4: HELA Cell Lysate Lane 5: COLO320 Cell Lysate Lane 6: PANC Cell Lysate Anti-PC1/3 antibody, IHC(P) IHC(P): Rat Intestine Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-PCSK1 antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959007 concentration 5 ug/ml. 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$511.50
Details
Human Rabbit Un-conjugated ELISA   100 μg Log in to see 16 Days
$163.90
Details
Human Rabbit Un-conjugated IHC (p), WB   100 μg Log in to see 8 to 10 Days
$463.83
Details
Human Rabbit Un-conjugated WB PCSK1 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit Un-conjugated WB   0.1 mL Log in to see 6 to 8 Days
$511.50
Details

PCSK1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
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Top referenced anti-PCSK1 Antibodies

  1. Human Monoclonal PCSK1 Primary Antibody for IF, WB - ABIN395943 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 5 references for ABIN395943

  2. Human Polyclonal PCSK1 Primary Antibody for ELISA - ABIN1995767 : Jackson, Creemers, Farooqi, Raffin-Sanson, Varro, Dockray, Holst, Brubaker, Corvol, Polonsky, Ostrega, Becker, Bertagna, Hutton, White, Dattani, Hussain, Middleton, Nicole, Milla, Lindley, ORahilly: Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. in The Journal of clinical investigation 2003 (PubMed)
    Show all 3 references for ABIN1995767

  3. Cow (Bovine) Polyclonal PCSK1 Primary Antibody for IHC, WB - ABIN2778153 : Rehfeld, Bundgaard, Hannibal, Zhu, Norrbom, Steiner, Friis-Hansen: The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6. in Endocrinology 2008 (PubMed)

More Antibodies against PCSK1 Interaction Partners

Zebrafish Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

  1. Pcsk1 has been sequenced and characterized.

Human Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

  1. these common variants in PCSK1 and POMC (show POMC Antibodies) were not the major cause of obesity in the Thai subjects sampled. However, variants in PCSK1 did affect cholesterol level, LDL-C level, and waist circumference.

  2. we demonstrate evidence that common gene variation in PCSK1 contributes to BMI variation and susceptibility to common obesity in the largest known meta-analysis published to date in genetic epidemiology.

  3. Data show that prohormone convertase 1/3 (PC1/3) endoplasmic reticulum-retained mutants induce endoplasmic reticulum stress.

  4. Mechanism of Fine-tuning pH Sensors in Proprotein Convertases: IDENTIFICATION OF A pH-SENSING HISTIDINE PAIR IN THE PROPEPTIDE OF PROPROTEIN CONVERTASE 1/3.

  5. We showed for the first time that a nonsense mutation in PCSK1 was likely to cause dominantly inherited human obesity, due to the inhibiting properties of the propeptide fragment encoded by the null allele

  6. Epistases between single nucleotide polymorphisms within proprotein convertase subtilisin/kexin type 1(PCSK1) and dopamine beta-hydroxylase(DBH (show DBH Antibodies)) genes are significantly associated with susceptibility or resistance to premature ovarian failure

  7. FTO (show FTO Antibodies)-rs9939609, TMEM18 (show TMM18 Antibodies)-rs6548238 and PCSK1-rs6234 polymorphisms are significantly associated with body mass index in a southern Chinese population.

  8. Common genetic variants in PCSK1 are associated with coronary artery disease in Chinese patients with type 2 diabetes.

  9. PC1/3(S357G) exhibited a lower calcium dependence; a higher pH optimum.

  10. PCSK1 is overexpressed in fibrolamellar hepatocellular carcinoma.

Cow (Bovine) Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

  1. Prohormone convertase PC1 expression is up-regulated in a cell-specific manner in bovine neuroendocrine ocular ciliary epithelium.

  2. a model of the membrane topology of the prohomone convertase PC3, where it is anchored to lipid rafts in secretory granule membranes via the transmembrane domain

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

  1. PC1 and PC2 (show CBX4 Antibodies) are involved in the C-terminal processing of protachykinin peptides and suggest a major role in the maturation of the protachykinin-1 (show TAC1 Antibodies) protein

  2. Binding of MAGP2 (show MFAP5 Antibodies) to microfibrils is regulated by proprotein convertase cleavage.

  3. Data indicate that the mutant PC1/3-N222D protein coimmunoprecipitates with wildtype(WT) prohormone convertase 1/3 (PC1/3) and exerts a modest effect on intracellular retention of the WT enzyme.

  4. proSAAS (show PCSK1N Antibodies) as a novel down-regulated target of Pax6 (show PAX6 Antibodies)

  5. Loss of PC1 in mice showed a dramatic decrease in the biosynthesis of all proTRH-derived peptides analyzed including TRH (show TRH Antibodies) and its immediate precursor TRH (show TRH Antibodies)-Gly.

  6. PC1/3 also has an important role in the regulation of the innate immune system, most likely through the regulation of cytokine secretion in macrophages.

  7. Reports demonstrate that mouse proprotein convertase 1/3 (mPC1 (show BRP44L Antibodies)/3) has a lag (show STMN1 Antibodies) phase of activation by substrates that can be interpreted as a hysteretic behavior of the enzyme for their hydrolysis.

  8. Intraislet production of GLP-1 (show GCG Antibodies) by activation of prohormone convertase 1/3 in pancreatic alpha-cells in mouse models of ss-cell regeneration.

  9. Data suggest that PC1/3 and many convertase-specific properties are attributable less to convertase-specific catalytic cleft residues than to convertase-specific domain interactions.

  10. These results demonstrate a prominent role for cathepsin L (show CTSL1 Antibodies), jointly with PC1/3 and PC2 (show CBX4 Antibodies), for production of dynorphins in brain.

Pig (Porcine) Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

  1. Study identified 14 polymorphisms that were organized in nine haplotypes, clearly distributed in two clades of putative European and Asian origin and showed that the porcine PCSK1 gene is associated with fat deposition.

PCSK1 Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PCSK1

  • proprotein convertase subtilisin/kexin type 1 (pcsk1) antibody
  • prohormone convertase 1 (PC1B) antibody
  • prohormone convertase 1 (LOC100534403) antibody
  • prohormone convertase 1 (LOC100534404) antibody
  • proprotein convertase subtilisin/kexin type 1 (PCSK1) antibody
  • proprotein convertase subtilisin/kexin type 1 (Pcsk1) antibody
  • BDP antibody
  • BMIQ12 antibody
  • Nec-1 antibody
  • Nec1 antibody
  • PC1 antibody
  • PC1/3 antibody
  • PC3 antibody
  • Phpp-1 antibody
  • SPC3 antibody

Protein level used designations for PCSK1

neuroendocrine convertase 1 , prohormone convertase 1 , NEC 1 , prohormone convertase 3 , Protein convertase subtilisin / kexin type I , Protein convertase subtilisin / kexin, type I , proprotein convertase 1 , furin homolog , prohormone convertase 1/3 , propeptide-processing protease , prohormone convertase

GENE ID SPECIES
100005716 Danio rerio
100533213 Aplysia californica
100534403 Oreochromis niloticus
100534404 Oreochromis niloticus
5122 Homo sapiens
25204 Rattus norvegicus
281967 Bos taurus
18548 Mus musculus
479149 Canis lupus familiaris
397103 Sus scrofa
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