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Proprotein Convertase Subtilisin/kexin Type 1 Proteins (PCSK1)

The protein encoded by PCSK1 belongs to the subtilisin-like proprotein convertase family. Additionally we are shipping PCSK1 Antibodies (30) and PCSK1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PCSK1 5122 P29120
PCSK1 25204 P28840
PCSK1 18548 P63239
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Top PCSK1 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,859.17
Details
HOST_HEK-293 Human His tag   0.025 mg Log in to see 2 to 3 Days
$653.13
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 9 to 11 Days
$229.85
Details

PCSK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Rat (Rattus)

Mouse (Murine)

Top referenced PCSK1 Proteins

  1. Human PCSK1 Protein expressed in Human Cells - ABIN2002138 : Jackson, Creemers, Farooqi, Raffin-Sanson, Varro, Dockray, Holst, Brubaker, Corvol, Polonsky, Ostrega, Becker, Bertagna, Hutton, White, Dattani, Hussain, Middleton, Nicole, Milla, Lindley, ORahilly: Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. in The Journal of clinical investigation 2003 (PubMed)
    Show all 4 references for ABIN2002138

More Proteins for Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) Interaction Partners

Zebrafish Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

  1. Pcsk1 has been sequenced and characterized.

Human Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

  1. these common variants in PCSK1 and POMC (show POMC Proteins) were not the major cause of obesity in the Thai subjects sampled. However, variants in PCSK1 did affect cholesterol level, LDL-C level, and waist circumference.

  2. we demonstrate evidence that common gene variation in PCSK1 contributes to BMI variation and susceptibility to common obesity in the largest known meta-analysis published to date in genetic epidemiology.

  3. Data show that prohormone convertase 1/3 (PC1/3) endoplasmic reticulum-retained mutants induce endoplasmic reticulum stress.

  4. Mechanism of Fine-tuning pH Sensors in Proprotein Convertases: IDENTIFICATION OF A pH-SENSING HISTIDINE PAIR IN THE PROPEPTIDE OF PROPROTEIN CONVERTASE 1/3.

  5. We showed for the first time that a nonsense mutation in PCSK1 was likely to cause dominantly inherited human obesity, due to the inhibiting properties of the propeptide fragment encoded by the null allele

  6. Epistases between single nucleotide polymorphisms within proprotein convertase subtilisin/kexin type 1(PCSK1) and dopamine beta-hydroxylase(DBH (show DBH Proteins)) genes are significantly associated with susceptibility or resistance to premature ovarian failure

  7. FTO (show FTO Proteins)-rs9939609, TMEM18 (show TMM18 Proteins)-rs6548238 and PCSK1-rs6234 polymorphisms are significantly associated with body mass index in a southern Chinese population.

  8. Common genetic variants in PCSK1 are associated with coronary artery disease in Chinese patients with type 2 diabetes.

  9. PC1/3(S357G) exhibited a lower calcium dependence; a higher pH optimum.

  10. PCSK1 is overexpressed in fibrolamellar hepatocellular carcinoma.

Cow (Bovine) Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

  1. Prohormone convertase PC1 expression is up-regulated in a cell-specific manner in bovine neuroendocrine ocular ciliary epithelium.

  2. a model of the membrane topology of the prohomone convertase PC3, where it is anchored to lipid rafts in secretory granule membranes via the transmembrane domain

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

  1. PC1 and PC2 (show CBX4 Proteins) are involved in the C-terminal processing of protachykinin peptides and suggest a major role in the maturation of the protachykinin-1 (show TAC1 Proteins) protein

  2. Binding of MAGP2 (show MFAP5 Proteins) to microfibrils is regulated by proprotein convertase cleavage.

  3. Data indicate that the mutant PC1/3-N222D protein coimmunoprecipitates with wildtype(WT) prohormone convertase 1/3 (PC1/3) and exerts a modest effect on intracellular retention of the WT enzyme.

  4. proSAAS (show PCSK1N Proteins) as a novel down-regulated target of Pax6 (show PAX6 Proteins)

  5. Loss of PC1 in mice showed a dramatic decrease in the biosynthesis of all proTRH-derived peptides analyzed including TRH (show TRH Proteins) and its immediate precursor TRH (show TRH Proteins)-Gly.

  6. PC1/3 also has an important role in the regulation of the innate immune system, most likely through the regulation of cytokine secretion in macrophages.

  7. Reports demonstrate that mouse proprotein convertase 1/3 (mPC1 (show BRP44L Proteins)/3) has a lag (show STMN1 Proteins) phase of activation by substrates that can be interpreted as a hysteretic behavior of the enzyme for their hydrolysis.

  8. Intraislet production of GLP-1 (show GCG Proteins) by activation of prohormone convertase 1/3 in pancreatic alpha-cells in mouse models of ss-cell regeneration.

  9. Data suggest that PC1/3 and many convertase-specific properties are attributable less to convertase-specific catalytic cleft residues than to convertase-specific domain interactions.

  10. These results demonstrate a prominent role for cathepsin L (show CTSL1 Proteins), jointly with PC1/3 and PC2 (show CBX4 Proteins), for production of dynorphins in brain.

Pig (Porcine) Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

  1. Study identified 14 polymorphisms that were organized in nine haplotypes, clearly distributed in two clades of putative European and Asian origin and showed that the porcine PCSK1 gene is associated with fat deposition.

PCSK1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PCSK1

  • proprotein convertase subtilisin/kexin type 1 (pcsk1)
  • prohormone convertase 1 (PC1B)
  • prohormone convertase 1 (LOC100534403)
  • prohormone convertase 1 (LOC100534404)
  • proprotein convertase subtilisin/kexin type 1 (PCSK1)
  • proprotein convertase subtilisin/kexin type 1 (Pcsk1)
  • BDP protein
  • BMIQ12 protein
  • Nec-1 protein
  • Nec1 protein
  • PC1 protein
  • PC1/3 protein
  • PC3 protein
  • Phpp-1 protein
  • SPC3 protein

Protein level used designations for PCSK1

neuroendocrine convertase 1 , prohormone convertase 1 , NEC 1 , prohormone convertase 3 , Protein convertase subtilisin / kexin type I , Protein convertase subtilisin / kexin, type I , proprotein convertase 1 , furin homolog , prohormone convertase 1/3 , propeptide-processing protease , prohormone convertase

GENE ID SPECIES
100005716 Danio rerio
100533213 Aplysia californica
100534403 Oreochromis niloticus
100534404 Oreochromis niloticus
5122 Homo sapiens
25204 Rattus norvegicus
281967 Bos taurus
18548 Mus musculus
479149 Canis lupus familiaris
397103 Sus scrofa
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