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Members of the subtilisin-like proprotein convertase family process latent precursor proteins into their biologically active products. Additionally we are shipping PCSK1N Antibodies (36) and PCSK1N Kits (5) and many more products for this protein.
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Cloning of proSAAS homologs in Danio and Xenopus identifies conserved, putatively functional areas.
although both proSAAS and 7B2 (show SCG5 Proteins) potently inhibit PC enzymes via a C-terminal peptide, their intracellular interactions with PCs appear to differ significantly, with each binding protein exhibiting unique properties
ProSAAS or proSAAS-like molecules are trapped within tau fibrils and accumulate in tau inclusions in patients with Alzheimer's disease and parkinsonism-dementia complex.
proSAAS may play a role in Alzheimer's disease pathology
the effects of the neuroendocrine secretory proteins proSAAS on hIAPP fibrillation in vitro and on cytotoxicity.
proSAAS as a novel down-regulated target of Pax6 (show PAX6 Proteins)
ProSAAS-derived peptides are colocalized with neuropeptide Y (show NPY Proteins) and function as neuropeptides in the regulation of food intake
mice lacking proSAAS have normal levels of all peptides suggesting that prohormone convertase 1 (show PCSK1 Proteins) activity is not affected by the absence of proSAAS in adult mice
ProSAAS and prohormone convertase 1 (show PCSK1 Proteins) are broadly expressed during mouse development
Although proSAAS expression overlaps with PC1 (show PCSK1 Proteins) in several regions, its overall expression pattern is significantly more extensive, suggesting that proSAAS may be multifunctional during nervous system development.
Members of the subtilisin-like proprotein convertase family process latent precursor proteins into their biologically active products. The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors.
granin-like neuroendocrine peptide
, proprotein convertase 1 inhibitor
, basic protein IA-4
, big PEN LEN
, big SAAS
, little LEN
, little SAAS
, pancreas protein 3
, protein serine alanine alanine serine