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PCSK2 encodes a member of the subtilisin-like proprotein convertase family. Additionally we are shipping Proprotein Convertase Subtilisin/kexin Type 2 Proteins (6) and Proprotein Convertase Subtilisin/kexin Type 2 Kits (5) and many more products for this protein.
Showing 10 out of 62 products:
Human Polyclonal PCSK2 Primary Antibody for WB - ABIN611197
Discher, Bishopric, Wu, Peterson, Webster: Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element. in The Journal of biological chemistry 1998
Show all 3 references for ABIN611197
Human Polyclonal PCSK2 Primary Antibody for IF (p), IHC (p) - ABIN1385997
van Rijn, Pouwer, Tryfonidou, Grinwis, van der Bend, Beukers, Vastenhout, Drouin, Penning, Meij: Expression and clinical relevance of paired box protein 7 and sex determining region Y-box 2 in canine corticotroph pituitary adenomas. in Veterinary journal (London, England : 1997) 2015
Human Polyclonal PCSK2 Primary Antibody for EIA, WB - ABIN453255
Leak, Keene, Langefeld, Gallagher, Mychaleckyj, Freedman, Bowden, Rich, Sale: Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population. in Molecular genetics and metabolism 2007
Pcsk2 has been sequenced and characterized.
PCSK2 gene polymorphisms are associated with pleiotropic effects on various traits of glucose homeostasis and incident diabetes.
FAM20C (show FAM20C Antibodies) plays a role in 7B2 (show SCG5 Antibodies)-mediated proPC2 activation by phosphorylating residue Thr111; and that 7B2 (show SCG5 Antibodies) function is regulated by alternative splicing.
Cbx4 (show CBX4 Antibodies) is an independent prognostic factor for HCC (show FAM126A Antibodies) patients, and the patients with high Cbx4 (show CBX4 Antibodies) expression should receive postoperative TACE (show ADAM17 Antibodies) treatment to improve their survival
our study demonstrated that miR (show MLXIP Antibodies)-195 acts as a tumor suppressor by directly targeting CBX4 (show CBX4 Antibodies) in hepatocellular carcinoma
Role of Cbx4 in migration and metastasis of a metastatic hepatocellular carcinoma cell line. Results show that Cbx4 overexpression increases the in vitro vessel formation of vascular endothelial cells in its SUMO interaction motifs-dependent manner.
The presence of CBX4-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.
High cytoplasmic expression of CBX4 (show CBX4 Antibodies) is associated with hepatocellular carcinoma.
our findings demonstrate that Cbx4 (show CBX4 Antibodies) plays a critical role in tumor angiogenesis by governing HIF-1alpha (show HIF1A Antibodies) protein
in the processing of hypothalamic neuropeptides in huntington disease (show HTT Antibodies) may partially arise from decreased PC1/3 (show PCSK1 Antibodies) and PC2 (show KRT6B Antibodies) expressions.
variant of the PCSK2 gene was associated with reduced glucose-stimulated insulin (show INS Antibodies) secretion, but also with lower glucagon (show GCG Antibodies) levels, which could potentially counteract the effects of decreased insulin (show INS Antibodies) secretion on the risk of type 2 diabetes
PC1 (show PCSK1 Antibodies) and PC2 (show CBX4 Antibodies) are involved in the C-terminal processing of protachykinin peptides and suggest a major role in the maturation of the protachykinin-1 (show TAC1 Antibodies) protein
activation of the hypothalamic GPR40 (show FFAR1 Antibodies)/FFA1 signaling pathway may regulate beta-endorphin (show POMC Antibodies) release via PC2 (show CBX4 Antibodies), and regulate the endogenous pain control system
Pkd2 (show PKD2 Antibodies)(-/-) mice with homozygous PKD2 (show PKD2 Antibodies)(tg)-transgene alleles (Pkd2 (show PKD2 Antibodies)(-/-);PKD2 (show PKD2 Antibodies)(tg/tg (show CACNA1A Antibodies))) showed significant further amelioration of the cystic severity compared to that in Pkd2 (show PKD2 Antibodies)(-/-) mice
Pkd1 (show PKD1 Antibodies) and Pkd2 (show PKD2 Antibodies) have coordinate effects on osteoblast differentiation and opposite effects on adipogenesis, suggesting that Pkd1 (show PKD1 Antibodies) and Pkd2 (show PKD2 Antibodies) signaling pathways can have independent effects on mesenchymal lineage commitment in bone
novel protein complex composed of Rabep1 (show RABEP1 Antibodies), GGA1 (show GGA1 Antibodies) and Arl3 is responsible for the sorting and targeting of the polycystin 1 (show PKD1 Antibodies) andpolycystin 2 to the cilium.
Verified the roles of proprotein convertase subtilisin/kexin type 2 in regulating IGF1 (show IGF1 Antibodies) and female sexual maturation, it also might be involved in the regulation of aging.
PKD2 (show PKD2 Antibodies) regulates directly and indirectly about 5% of the cytotoxic T-cell phosphoproteome.
The results of this study demonstrate that PC1 (show PCSK1 Antibodies) trafficking and expression require GPS (show NBEAL2 Antibodies) cleavage and PC2 (show CBX4 Antibodies) interaction, respectively, and provide a framework for functional assays to categorize the effects of missense mutations in polycystins.
In inner medullary collecting duct, flow, via polycystin-2 (show PKD2 Antibodies) and P2 receptors, engages Ca(2 (show CA2 Antibodies)+)-dependent signaling pathways that stimulate ET-1 (show EDN1 Antibodies) synthesis.
Pkd2 (show PKD2 Antibodies)(+/-) cardiomyocytes shift the beta adrenergic receptor pathway and have altered calcium handling, independent of desensitized calcium-contraction coupling.
Prohormone convertase PC2 expression is up-regulated in a cell-specific manner in bovine neuroendocrine ocular ciliary epithelium.
This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
proprotein convertase subtilisin/kexin type 2
, neuroendocrine convertase 2
, proprotein convertase type 2
, convertase PC2
, prohormone convertase 2
, E3 SUMO-protein ligase CBX4
, NS5ATP1-binding protein 16
, Pc class 2 homolog
, chromobox homolog 4 (Pc class homolog, Drosophila)
, chromobox protein homolog 4
, polycomb 2 homolog
, polycystic kidney disease 2 protein homolog
, polycystin 2
, KEX2-like endoprotease 2
, NEC 2
, proprotein convertase 2