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Proprotein Convertase Subtilisin/kexin Type 2 Proteins (PCSK2)

PCSK2 encodes a member of the subtilisin-like proprotein convertase family. Additionally we are shipping Proprotein Convertase Subtilisin/kexin Type 2 Antibodies (61) and Proprotein Convertase Subtilisin/kexin Type 2 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PCSK2 8535 O00257
PCSK2 18764 O35245
PCSK2 25121 P28841
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Top Proprotein Convertase Subtilisin/kexin Type 2 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,509.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PCSK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Proprotein Convertase Subtilisin/kexin Type 2 (PCSK2) Interaction Partners

Zebrafish Proprotein Convertase Subtilisin/kexin Type 2 (PCSK2) interaction partners

  1. Pcsk2 has been sequenced and characterized.

Human Proprotein Convertase Subtilisin/kexin Type 2 (PCSK2) interaction partners

  1. PCSK2 gene polymorphisms are associated with pleiotropic effects on various traits of glucose homeostasis and incident diabetes.

  2. FAM20C (show FAM20C Proteins) plays a role in 7B2 (show SCG5 Proteins)-mediated proPC2 activation by phosphorylating residue Thr111; and that 7B2 (show SCG5 Proteins) function is regulated by alternative splicing.

  3. Cbx4 (show CBX4 Proteins) is an independent prognostic factor for HCC (show FAM126A Proteins) patients, and the patients with high Cbx4 (show CBX4 Proteins) expression should receive postoperative TACE (show ADAM17 Proteins) treatment to improve their survival

  4. our study demonstrated that miR (show MLXIP Proteins)-195 acts as a tumor suppressor by directly targeting CBX4 (show CBX4 Proteins) in hepatocellular carcinoma

  5. Role of Cbx4 in migration and metastasis of a metastatic hepatocellular carcinoma cell line. Results show that Cbx4 overexpression increases the in vitro vessel formation of vascular endothelial cells in its SUMO interaction motifs-dependent manner.

  6. The presence of CBX4-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.

  7. High cytoplasmic expression of CBX4 (show CBX4 Proteins) is associated with hepatocellular carcinoma.

  8. our findings demonstrate that Cbx4 (show CBX4 Proteins) plays a critical role in tumor angiogenesis by governing HIF-1alpha (show HIF1A Proteins) protein

  9. in the processing of hypothalamic neuropeptides in huntington disease (show HTT Proteins) may partially arise from decreased PC1/3 (show PCSK1 Proteins) and PC2 (show KRT6B Proteins) expressions.

  10. variant of the PCSK2 gene was associated with reduced glucose-stimulated insulin (show INS Proteins) secretion, but also with lower glucagon (show GCG Proteins) levels, which could potentially counteract the effects of decreased insulin (show INS Proteins) secretion on the risk of type 2 diabetes

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 2 (PCSK2) interaction partners

  1. PC1 (show PCSK1 Proteins) and PC2 (show CBX4 Proteins) are involved in the C-terminal processing of protachykinin peptides and suggest a major role in the maturation of the protachykinin-1 (show TAC1 Proteins) protein

  2. activation of the hypothalamic GPR40/FFA1 signaling pathway may regulate beta-endorphin (show POMC Proteins) release via PC2 (show CBX4 Proteins), and regulate the endogenous pain control system

  3. Pkd2 (show PKD2 Proteins)(-/-) mice with homozygous PKD2 (show PKD2 Proteins)(tg)-transgene alleles (Pkd2 (show PKD2 Proteins)(-/-);PKD2 (show PKD2 Proteins)(tg/tg (show CACNA1A Proteins))) showed significant further amelioration of the cystic severity compared to that in Pkd2 (show PKD2 Proteins)(-/-) mice

  4. Pkd1 (show PKD1 Proteins) and Pkd2 (show PKD2 Proteins) have coordinate effects on osteoblast differentiation and opposite effects on adipogenesis, suggesting that Pkd1 (show PKD1 Proteins) and Pkd2 (show PKD2 Proteins) signaling pathways can have independent effects on mesenchymal lineage commitment in bone

  5. novel protein complex composed of Rabep1, GGA1 (show GGA1 Proteins) and Arl3 is responsible for the sorting and targeting of the polycystin 1 (show PKD1 Proteins) andpolycystin 2 to the cilium.

  6. Verified the roles of proprotein convertase subtilisin/kexin type 2 in regulating IGF1 (show IGF1 Proteins) and female sexual maturation, it also might be involved in the regulation of aging.

  7. PKD2 (show PKD2 Proteins) regulates directly and indirectly about 5% of the cytotoxic T-cell phosphoproteome.

  8. The results of this study demonstrate that PC1 (show PCSK1 Proteins) trafficking and expression require GPS cleavage and PC2 (show CBX4 Proteins) interaction, respectively, and provide a framework for functional assays to categorize the effects of missense mutations in polycystins.

  9. In inner medullary collecting duct, flow, via polycystin-2 (show PKD2 Proteins) and P2 receptors, engages Ca(2 (show CA2 Proteins)+)-dependent signaling pathways that stimulate ET-1 (show EDN1 Proteins) synthesis.

  10. Pkd2 (show PKD2 Proteins)(+/-) cardiomyocytes shift the beta adrenergic receptor pathway and have altered calcium handling, independent of desensitized calcium-contraction coupling.

Cow (Bovine) Proprotein Convertase Subtilisin/kexin Type 2 (PCSK2) interaction partners

  1. Prohormone convertase PC2 expression is up-regulated in a cell-specific manner in bovine neuroendocrine ocular ciliary epithelium.

Proprotein Convertase Subtilisin/kexin Type 2 (PCSK2) Protein Profile

Protein Summary

This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with PCSK2

  • proprotein convertase subtilisin/kexin type 2 (PCSK2)
  • proprotein convertase subtilisin/kexin type 2 (pcsk2)
  • proprotein convertase subtilisin/kexin type 2 (LOC100358339)
  • prohormone convertase 2 (LOC100534405)
  • prohormone convertase 2 (LOC100534564)
  • chromobox homolog 4 (CBX4)
  • polycystic kidney disease 2 (Pkd2)
  • pro-hormone convertase (PC2)
  • proprotein convertase subtilisin/kexin type 2 (Pcsk2)
  • 6330411F23Rik protein
  • AI839700 protein
  • C030034P18Rik protein
  • NBP16 protein
  • Nec-2 protein
  • Nec2 protein
  • NEC 2 protein
  • PC2 protein
  • PCSK2 protein
  • Phpp-2 protein
  • SPC2 protein
  • TRPP2 protein

Protein level used designations for PCSK2

proprotein convertase subtilisin/kexin type 2 , neuroendocrine convertase 2 , proprotein convertase type 2 , convertase PC2 , prohormone convertase 2 , E3 SUMO-protein ligase CBX4 , NS5ATP1-binding protein 16 , Pc class 2 homolog , chromobox homolog 4 (Pc class homolog, Drosophila) , chromobox protein homolog 4 , polycomb 2 homolog , polycystic kidney disease 2 protein homolog , polycystin 2 , polycystin-2 , KEX2-like endoprotease 2 , NEC 2 , proprotein convertase 2 , PC2

GENE ID SPECIES
458106 Pan troglodytes
485757 Canis lupus familiaris
579017 Strongylocentrotus purpuratus
695730 Macaca mulatta
100004460 Danio rerio
100085012 Ornithorhynchus anatinus
100358339 Oryctolagus cuniculus
100036632 Xenopus (Silurana) tropicalis
100534405 Oreochromis niloticus
100534564 Oreochromis niloticus
100606456 Nomascus leucogenys
8535 Homo sapiens
18764 Mus musculus
445533 Sus scrofa
5126 Homo sapiens
25121 Rattus norvegicus
18549 Mus musculus
281968 Bos taurus
100171744 Pongo abelii
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