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Proprotein Convertase Subtilisin/kexin Type 4 Proteins (PCSK4)

PCSK4 encodes a member of the subtilisin-like proprotein convertase family. Additionally we are shipping PCSK4 Antibodies (51) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PCSK4 29596 P20695
PCSK4 54760 Q6UW60
PCSK4 18551 P29121
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Top PCSK4 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,630.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 1 to 2 Days
$443.33
Details

PCSK4 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , ,
,
Mouse (Murine)

More Proteins for Proprotein Convertase Subtilisin/kexin Type 4 (PCSK4) Interaction Partners

Human Proprotein Convertase Subtilisin/kexin Type 4 (PCSK4) interaction partners

  1. Maturation by propeptide removal occurs very inefficiently when rat or human proPCSK4 is overexpressed in HEK293 cells where it interacts with BiP.

  2. abnormal processing of IGF-II by PC4 (show IFRD1 Proteins) may represent a previously uncharacterized mechanism involved in the pathophysiology of fetoplacental growth restriction

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 4 (PCSK4) interaction partners

  1. Results suggest that positive cofactor 4 (Pc4) has an important role in inducing spontaneous somatic cell reprogramming via up-regulation of key pluripotency genes.

  2. CRES (show CST8 Proteins) may be a regulator of PC4 (show IFRD1 Proteins) in sperm-egg interaction and fertilization.

  3. Data suggest that the fertility defect in PCSK4 knockout mice is due, in part, to altered processing/proteolysis of ACRBP (show ACRBP Proteins) (proacrosin/acrosin (show ACR Proteins) binding protein sp32 (show ACRBP Proteins)) as well as structural abnormalities in sperm heads and acrosomes.

  4. thatADAM2may be a natural substrate of sperm PCSK4 and its cleavage by the enzyme during acrosome reaction may be relevant to the fertilization process.

  5. Efficient activation and trafficking of PCSK4 requires a special environment, which presumably exists in testicular germ cells where it is highly expressed, but not in somatic cells where it is not or is barely expressed.

  6. Alterations in signal transduction and proteolytic processing during in vitro capacitation may underlie the fertilization incompetence of PCSK4-null sperm.

  7. Redox-mediated upregulation of hepatocyte iNOS (show NOS2 Proteins) transcription requires an HNF-4alpha (show HNF4A Proteins)-PC4 (show IFRD1 Proteins) transcriptional complex

  8. Report recruitment of RNA polymerase II cofactor PC4 (show IFRD1 Proteins) to DNA damage sites.

  9. PCSK4-null sperm underwent capacitation at a faster rate; they were induced to acrosome react by lower concentrations of zona pellucida; and their egg-binding ability was only half that of wild-type sperm.

PCSK4 Protein Profile

Protein Summary

This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in reproduction and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein (proPACAP) and pro-insulin-like growth factor II.

Gene names and symbols associated with PCSK4

  • proprotein convertase subtilisin/kexin type 4 (PCSK4)
  • proprotein convertase subtilisin/kexin type 4 (pcsk4)
  • interferon-related developmental regulator 1 (Ifrd1)
  • proprotein convertase subtilisin/kexin type 4 (Pcsk4)
  • SUB1 homolog (S. cerevisiae) (Sub1)
  • AI647044 protein
  • AI842364 protein
  • L21221 protein
  • MGC146505 protein
  • NEC 3 protein
  • NEC3 protein
  • P9 protein
  • P15 protein
  • PC4 protein
  • PCSK4 protein
  • Rpo2tc1 protein
  • SPC5 protein

Protein level used designations for PCSK4

proprotein convertase subtilisin/kexin type 4 , IRPR , nerve growth factor-inducible protein PC4 , KEX2-like endoprotease 3 , neuroendocrine convertase 3 , prohormone convertase 3 , NEC 3 , PC4 , RNA polymerase II transcriptional coactivator , activated RNA polymerase II transcriptional coactivator p15 , p14 , positive cofactor 4 , single-stranded DNA-binding protein p9

GENE ID SPECIES
485083 Canis lupus familiaris
508744 Bos taurus
707567 Macaca mulatta
779814 Xenopus (Silurana) tropicalis
749996 Pan troglodytes
29596 Rattus norvegicus
54760 Homo sapiens
18551 Mus musculus
171085 Rattus norvegicus
20024 Mus musculus
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