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Proprotein Convertase Subtilisin/kexin Type 7 Proteins (PCSK7)

The protein encoded by PCSK7 belongs to the subtilisin-like proprotein convertase family. Additionally we are shipping Proprotein Convertase Subtilisin/kexin Type 7 Antibodies (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PCSK7 9159 Q16549
PCSK7 18554 Q61139
PCSK7 29606 Q62849
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Top Proprotein Convertase Subtilisin/kexin Type 7 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag   10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,498.00
Details

PCSK7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

Top referenced Proprotein Convertase Subtilisin/kexin Type 7 Proteins

  1. Human PCSK7 Protein expressed in Wheat germ - ABIN1314363 : Heng, Dynon, Li, Edgell, Walton, Rombauts, Vollenhoven, Nie: Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity. in Analytical biochemistry 2015 (PubMed)

More Proteins for Proprotein Convertase Subtilisin/kexin Type 7 (PCSK7) Interaction Partners

Xenopus laevis Proprotein Convertase Subtilisin/kexin Type 7 (PCSK7) interaction partners

  1. SPC7 is required for normal development of the eye and brain, possibly through processing BMPs, though other potential substrates cannot be excluded.

Zebrafish Proprotein Convertase Subtilisin/kexin Type 7 (PCSK7) interaction partners

  1. PCSK7 is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.

Human Proprotein Convertase Subtilisin/kexin Type 7 (PCSK7) interaction partners

  1. Furin (show FURIN Proteins) and PC7 siRNAs induced HIF-1alpha (show HIF1A Proteins) protein by increasing its translation, resulting in upregulation of VEGF-A (show VEGFA Proteins).

  2. The data suggest that PCSK7 genotypes may interact with dietary CHO intake on changes in insulin (show INS Proteins) sensitivity in the white Americans.

  3. Results demonstrate that PCSK7 variation is a strong host risk factor of liver cirrhosis in hereditary hemochromatosis (show HFE Proteins) patients homozygous for HFE (show HFE Proteins) C282Y.

  4. overexpression of PCs, furin (show FURIN Proteins) and PC5 (show PCSK5 Proteins), but not PC7, which are all expressed in SMC (show DYM Proteins), increase PKGI (show PRKG1 Proteins) cleavage in a dose-dependent manner

  5. Among the PC family members, only furin (show FURIN Proteins) activates hepcidin (show HAMP Proteins) in hepatocytes, and uniquely the full-length membrane-bound PC7 can directly shed hTfR1 by cleavage at Arg100

  6. PCSK7 is involved in sTfR (show TFRC Proteins) generation and iron homeostasis.

  7. Proprotein convertase PC7 enhances the activation of the EGF receptor (show EGFR Proteins) pathway through processing of the EGF (show EGF Proteins) precursor.

  8. PC7 is distinct from other proprotein convertases in its zymogen activation, subcellular localization, and trafficking.

  9. Mass spectrometry analysis provides evidence that the HLA-B51-presented peptide profile is altered in the absence of peptide-loading complex quality control or lack of PC7 function in major histocompatibility (MHC) class I-mediated antigen presentation.

  10. we investigated the specificity and potency of complete prodomains and short C-terminal prodomain peptides of each SPC (show UCN3 Proteins) on highly purified, soluble enzyme preparations of human SPC1 (show FURIN Proteins), SPC6 (show PCSK5 Proteins), and SPC7.

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 7 (PCSK7) interaction partners

  1. PC7 and the related proteases Furin (show FURIN Proteins) and Pace4 regulate E-cadherin (show CDH1 Proteins) function during blastocyst formation.

  2. Data show that BDNF (show BDNF Proteins) and PC7 mRNAs are colocalized in hippocampus and amygdala and that mature BDNF (show BDNF Proteins) protein levels are reduced in these brain areas in proprotein convertase PC7 knockout mice.

  3. overexpression of PCs, furin (show FURIN Proteins) and PC5 (show PCSK5 Proteins), but not PC7, which are all expressed in SMC (show DYM Proteins), increase PKGI (show PRKG1 Proteins) cleavage in a dose-dependent manner

  4. Proprotein convertase PC7 enhances the activation of the EGF receptor (show EGFR Proteins) pathway through processing of the EGF (show EGF Proteins) precursor.

  5. in binding VEGFR-2 (show KDR Proteins), furin (show FURIN Proteins) and PC5 (show PCSK5 Proteins) promote cleavage of N-and C-terminal VEGF-D (show Figf Proteins) propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only

Proprotein Convertase Subtilisin/kexin Type 7 (PCSK7) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart.

Gene names and symbols associated with PCSK7

  • proprotein convertase subtilisin/kexin type 7 (PCSK7)
  • proprotein convertase subtilisin/kexin type 7 (pcsk7)
  • proprotein convertase subtilisin/kexin type 7 (Pcsk7)
  • AA959856 protein
  • LPC protein
  • MGC115258 protein
  • pc7 protein
  • PC8 protein
  • PCSK7 protein
  • SPC7 protein
  • wu:fj05c03 protein
  • zgc:158336 protein

Protein level used designations for PCSK7

proprotein convertase PC7 , proprotein convertase subtilisin/kexin type 7 , fj05c03 , proprotein convertase subtilisin/kexin type 7-like , hPC8 , lymphoma proprotein convertase , prohormone convertase 7 , prohormone convertase PC7 , proprotein convertase 7 , proprotein convertase 8 , subtilisin/kexin-like protease PC7 , subtilisin-like proprotein convertase 7 , rPC7

GENE ID SPECIES
395455 Gallus gallus
451571 Pan troglodytes
479423 Canis lupus familiaris
515398 Bos taurus
697567 Macaca mulatta
735091 Xenopus laevis
100009656 Danio rerio
100062727 Equus caballus
100388007 Callithrix jacchus
100461035 Pongo abelii
100544206 Meleagris gallopavo
9159 Homo sapiens
18554 Mus musculus
29606 Rattus norvegicus
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