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anti-Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Antibodies

PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. Additionally we are shipping Proprotein Convertase Subtilisin/kexin Type 9 Proteins (55) and Proprotein Convertase Subtilisin/kexin Type 9 Kits (54) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PCSK9 255738 Q8NBP7
PCSK9 100102 Q80W65
PCSK9 298296 P59996
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Top anti-Proprotein Convertase Subtilisin/kexin Type 9 Antibodies at antibodies-online.com

Showing 10 out of 142 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated IHC (p), WB 20 μg Log in to see 6 to 8 Days
$176.00
Details
Human Goat Un-conjugated EIA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PCSK... 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of PCSK9 Antibody (N-term) in Jurkat cell line l... 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of PCSK9 Antibody (N-term) (ABIN652320) in Jurka... PCSK9 Antibody (N-term) (ABIN652320) IHC analysis in formalin fixed an... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of PCSK9 antibody (C-term) (ABIN391505) in Hela ... PCSK9 Antibody (C-term) (ABIN391505) IHC analysis in formalin fixed an... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated EIA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PCSK... 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN185371 staining (0.2 µg/mL) of McA cell lysates: untransfected (1)... ABIN185371 (0.3 µg/mL) staining of Human Adipose lysate (35 µg protein... 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Mouse Un-conjugated ELISA   100 μg Log in to see 16 Days
$218.90
Details
Human Rabbit Un-conjugated IHC (p), WB 100 μg Log in to see 2 to 3 Days
$367.50
Details

PCSK9 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
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Top referenced anti-Proprotein Convertase Subtilisin/kexin Type 9 Antibodies

  1. Human Polyclonal PCSK9 Primary Antibody for WB - ABIN493159 : Yue, Averna, Lin, Schonfeld: The c.43_44insCTG variation in PCSK9 is associated with low plasma LDL-cholesterol in a Caucasian population. in Human mutation 2006 (PubMed)
    Show all 4 references for ABIN493159

  2. Human Monoclonal PCSK9 Primary Antibody for ELISA - ABIN1997157 : Qian, Schmidt, Zhang, Chu, Lin, Wang, Wang, Beyer, Bensch, Li, Ehsani, Lu, Konrad, Eacho, Moller, Karathanasis, Cao: Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. in Journal of lipid research 2007 (PubMed)
    Show all 4 references for ABIN1997157

  3. Human Polyclonal PCSK9 Primary Antibody for IHC (p), WB - ABIN782954 : Cohen, Pertsemlidis, Kotowski, Graham, Garcia, Hobbs: Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. in Nature genetics 2005 (PubMed)
    Show all 3 references for ABIN782954

  4. Human Polyclonal PCSK9 Primary Antibody for EIA, WB - ABIN453778 : McNutt, Kwon, Chen, Chen, Horton, Lagace: Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells. in The Journal of biological chemistry 2009 (PubMed)
    Show all 3 references for ABIN453778

  5. Human Polyclonal PCSK9 Primary Antibody for IHC, ELISA - ABIN185371 : Lalanne, Lambert, Amar, Chétiveaux, Zaïr, Jarnoux, Ouguerram, Friburg, Seidah, Brewer, Krempf, Costet: Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells. in Journal of lipid research 2005 (PubMed)
    Show all 2 references for ABIN185371

  6. Human Polyclonal PCSK9 Primary Antibody for FACS, IHC (p) - ABIN652320 : Shioji, Mannami, Kokubo, Inamoto, Takagi, Goto, Nonogi, Iwai: Genetic variants in PCSK9 affect the cholesterol level in Japanese. in Journal of human genetics 2004 (PubMed)
    Show all 2 references for ABIN652320

  7. Human Polyclonal PCSK9 Primary Antibody for FACS, IHC (p) - ABIN391505 : Abifadel, Varret, Rabès, Allard, Ouguerram, Devillers, Cruaud, Benjannet, Wickham, Erlich, Derré, Villéger, Farnier, Beucler, Bruckert, Chambaz, Chanu, Lecerf, Luc, Moulin, Weissenbach, Prat, Krempf et al.: Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. ... in Nature genetics 2003 (PubMed)
    Show all 2 references for ABIN391505

  8. Human Polyclonal PCSK9 Primary Antibody for EIA, WB - ABIN569616 : Kwon, Lagace, McNutt, Horton, Deisenhofer: Molecular basis for LDL receptor recognition by PCSK9. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

More Antibodies against Proprotein Convertase Subtilisin/kexin Type 9 Interaction Partners

Human Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. Serum PCSK9 concentration is associated with future risk of cardiovascular disease even after adjustments for established risk factors.

  2. Data show that leptin (show LEP Antibodies) replacement decreased proprotein convertase subtilisin/kexin type 9 (PCSK9) and improved lipid parameters in female lipodystrophic subject.

  3. Three polymorphisms in the 3' UTR (show UTS2R Antibodies) region of LDLR (show LDLR Antibodies), c.*52G>A, c.*504G>A, and c.*773A>G, and two at the 5' UTR (show UTS2R Antibodies) region of PCSK9, c.-3383C>G and c.-2063A>G, were associated with response to Armolipid Plus

  4. Data suggest that PCSK9 is involved in regulation of lipid metabolism in hepatocytes by proinflammatory cytokine TNFalpha (show TNF Antibodies); induction of lipogenesis and insulin (show INS Antibodies) resistance in liver (as seen in obesity) involves up-regulation of both PCSK9 and SOCS3 (show SOCS3 Antibodies).

  5. Thrombotic antiphospholipid antibody carriers showed significant association with PCSK9 gene, a regulator of LDLR (show LDLR Antibodies) plasma levels.

  6. PCSK9 E670G polymorphism was associated with coronary artery disease risk and blood lipid levels. (Meta-analysis)

  7. plasma apoB (show APOB Antibodies)-to-PCSK9 ratio provides a better clinical index than PCSK9 alone for monitoring early metabolic disturbances that may be promoted by reduction in plasma PCSK9

  8. PCSK9 p.R46L LOF variant was not associated with impaired glucose homeostasis in humans

  9. PCSK9 directly increases atherosclerotic lesion inflammation

  10. Findings provide evidence that PCSK9 has at least two endocytic epitopes that are utilized by a variety of internalization mechanisms and clarifies how PCSK9 may direct proteins to lysosomes.

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. that ox-LDL receptor-1 (show OLR1 Antibodies) and PCSK9 positively influence each other's expression, especially during an inflammatory reaction

  2. Data show that leptin (show LEP Antibodies) treatment suppresses proprotein convertase subtilisin/kexin type 9 (PCSK9) in male, but fails to suppress PCSK9 in female.

  3. The Liver Clock Controls Cholesterol Homeostasis through Trib1 (show TRIB1 Antibodies) Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR (show LDLR Antibodies)) Axis.

  4. Hepatic LDLR (show LDLR Antibodies) levels are up-regulated in SEC24A (show SEC24A Antibodies)-deficient cells as a consequence of specific dependence of PCSK9, a negative regulator of LDLR (show LDLR Antibodies), on SEC24A (show SEC24A Antibodies) for efficient exit from the ensoplasmic reticulum.

  5. PCSK9(-/-) mice display normal sodium balance and blood pressure regulation despite an increase of cleaved alphaENaC (show SCNN1A Antibodies) under basal condition

  6. PCSK9-mediated CD36 (show CD36 Antibodies) degradation may serve to limit fatty acid uptake and triglyceride accumulation in tissues, such as the liver and adipose tissue.

  7. HNF1alpha (show HNF1A Antibodies), but not HNF1beta (show HNF1B Antibodies), is the primary positive regulator of PCSK9 transcription in mouse liver

  8. high fructose consumption inversely modulates LDL-C and PCSK9 serum levels in mice without a significant impact on liver LDLR (show LDLR Antibodies) protein levels

  9. PCSK9-reactive oxygen species interaction may be important in the development of atherosclerosis in arterial channels with low shear stress.

  10. reduced PCSK9 function is associated with increased pathogen lipid clearance.

Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Antigen Profile

Protein Summary

This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Gene names and symbols associated with PCSK9

  • proprotein convertase subtilisin/kexin type 9 (pcsk9) antibody
  • proprotein convertase subtilisin/kexin type 9 (PCSK9) antibody
  • proprotein convertase subtilisin/kexin type 9 (Pcsk9) antibody
  • proprotein convertase subtilisin/kexin type 9-like (LOC100620501) antibody
  • AI415265 antibody
  • AI747682 antibody
  • FH3 antibody
  • HCHOLA3 antibody
  • LDLCQ1 antibody
  • NARC-1 antibody
  • Narc1 antibody
  • PC9 antibody

Protein level used designations for PCSK9

proprotein convertase subtilisin/kexin type 9 , convertase subtilisin/kexin type 9 preproprotein , neural apoptosis regulated convertase 1 , subtilisin/kexin-like protease PC9 , NARC-1 , convertase subtilisin , neural apoptosis-regulated convertase 1 , proprotein convertase 9 , proprotein convertase PC9 , proprotein convertase subtilisin/kexin type 9 preproprotein , Proprotein convertase 9 , Subtilisin/kexin-like protease PC9

GENE ID SPECIES
495509 Xenopus laevis
100150316 Danio rerio
100544916 Meleagris gallopavo
255738 Homo sapiens
100102 Mus musculus
298296 Rattus norvegicus
424664 Gallus gallus
100731533 Cavia porcellus
717147 Macaca mulatta
100971792 Pan paniscus
456880 Pan troglodytes
100395116 Callithrix jacchus
100620501 Sus scrofa
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