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PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. Additionally we are shipping PCSK9 Proteins (55) and PCSK9 Kits (54) and many more products for this protein.
Showing 10 out of 142 products:
Human Polyclonal PCSK9 Primary Antibody for WB - ABIN493159
Yue, Averna, Lin, Schonfeld: The c.43_44insCTG variation in PCSK9 is associated with low plasma LDL-cholesterol in a Caucasian population. in Human mutation 2006
Show all 4 references for ABIN493159
Human Polyclonal PCSK9 Primary Antibody for IHC (p), WB - ABIN782954
Cohen, Pertsemlidis, Kotowski, Graham, Garcia, Hobbs: Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. in Nature genetics 2005
Show all 3 references for ABIN782954
Human Polyclonal PCSK9 Primary Antibody for EIA, WB - ABIN453778
McNutt, Kwon, Chen, Chen, Horton, Lagace: Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells. in The Journal of biological chemistry 2009
Show all 3 references for ABIN453778
Human Polyclonal PCSK9 Primary Antibody for IHC, ELISA - ABIN185371
Lalanne, Lambert, Amar, Chétiveaux, Zaïr, Jarnoux, Ouguerram, Friburg, Seidah, Brewer, Krempf, Costet: Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells. in Journal of lipid research 2005
Show all 2 references for ABIN185371
Human Polyclonal PCSK9 Primary Antibody for FACS, IHC (p) - ABIN391505
Shioji, Mannami, Kokubo, Inamoto, Takagi, Goto, Nonogi, Iwai: Genetic variants in PCSK9 affect the cholesterol level in Japanese. in Journal of human genetics 2004
Show all 2 references for ABIN391505
Human Polyclonal PCSK9 Primary Antibody for FACS, IHC (p) - ABIN652320
Abifadel, Varret, Rabès, Allard, Ouguerram, Devillers, Cruaud, Benjannet, Wickham, Erlich, Derré, Villéger, Farnier, Beucler, Bruckert, Chambaz, Chanu, Lecerf, Luc, Moulin, Weissenbach, Prat, Krempf et al.: Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. ... in Nature genetics 2003
Show all 2 references for ABIN652320
Human Polyclonal PCSK9 Primary Antibody for EIA, WB - ABIN569616
Kwon, Lagace, McNutt, Horton, Deisenhofer: Molecular basis for LDL receptor recognition by PCSK9. in Proceedings of the National Academy of Sciences of the United States of America 2008
PCSK9 GOF mutation carriers have elevated LDL-C levels and are at high risk of premature cardiovascular disease.
Familial hypercholesterolemia individuals carry the PCSK9-InsLEU genetic variant benefit of lower risk of coronary events but show an increased occurrence of prediabetes and diabetes
Alirocumab is a fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9.
Data suggest plasma levels of PCSK9 (proprotein convertase subtilisin/kexin type 9) and lipoprotein(a) are significantly up-regulated in patients with type 2 diabetes as compared to control subject; study was conducted in Tunisia.
Serum PCSK9 concentration is associated with future risk of cardiovascular disease even after adjustments for established risk factors.
Data show that leptin (show LEP Antibodies) replacement decreased proprotein convertase subtilisin/kexin type 9 (PCSK9) and improved lipid parameters in female lipodystrophic subject.
Three polymorphisms in the 3' UTR (show UTS2R Antibodies) region of LDLR (show LDLR Antibodies), c.*52G>A, c.*504G>A, and c.*773A>G, and two at the 5' UTR (show UTS2R Antibodies) region of PCSK9, c.-3383C>G and c.-2063A>G, were associated with response to Armolipid Plus
Data suggest that PCSK9 is involved in regulation of lipid metabolism in hepatocytes by proinflammatory cytokine TNFalpha (show TNF Antibodies); induction of lipogenesis and insulin (show INS Antibodies) resistance in liver (as seen in obesity) involves up-regulation of both PCSK9 and SOCS3 (show SOCS3 Antibodies).
Thrombotic antiphospholipid antibody carriers showed significant association with PCSK9 gene, a regulator of LDLR (show LDLR Antibodies) plasma levels.
PCSK9 E670G polymorphism was associated with coronary artery disease risk and blood lipid levels. (Meta-analysis)
binding of PCSK9 to GRP94 (show HSP90B1 Antibodies) protects LDLR (show LDLR Antibodies) from degradation likely by preventing early binding of PCSK9 to LDLR (show LDLR Antibodies)
The absence of PCSK9 results in a sex- and tissue-specific subcellular distribution of the LDLR (show LDLR Antibodies) and VLDLR (show VLDLR Antibodies), which is determined by estradiol levels.
that ox-LDL receptor-1 (show OLR1 Antibodies) and PCSK9 positively influence each other's expression, especially during an inflammatory reaction
Data show that leptin (show LEP Antibodies) treatment suppresses proprotein convertase subtilisin/kexin type 9 (PCSK9) in male, but fails to suppress PCSK9 in female.
The Liver Clock Controls Cholesterol Homeostasis through Trib1 (show TRIB1 Antibodies) Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR (show LDLR Antibodies)) Axis.
Hepatic LDLR (show LDLR Antibodies) levels are up-regulated in SEC24A (show SEC24A Antibodies)-deficient cells as a consequence of specific dependence of PCSK9, a negative regulator of LDLR (show LDLR Antibodies), on SEC24A (show SEC24A Antibodies) for efficient exit from the ensoplasmic reticulum.
PCSK9(-/-) mice display normal sodium balance and blood pressure regulation despite an increase of cleaved alphaENaC (show SCNN1A Antibodies) under basal condition
PCSK9-mediated CD36 (show CD36 Antibodies) degradation may serve to limit fatty acid uptake and triglyceride accumulation in tissues, such as the liver and adipose tissue.
HNF1alpha (show HNF1A Antibodies), but not HNF1beta (show HNF1B Antibodies), is the primary positive regulator of PCSK9 transcription in mouse liver
high fructose consumption inversely modulates LDL-C and PCSK9 serum levels in mice without a significant impact on liver LDLR (show LDLR Antibodies) protein levels
This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
proprotein convertase subtilisin/kexin type 9
, convertase subtilisin/kexin type 9 preproprotein
, neural apoptosis regulated convertase 1
, subtilisin/kexin-like protease PC9
, convertase subtilisin
, neural apoptosis-regulated convertase 1
, proprotein convertase 9
, proprotein convertase PC9
, proprotein convertase subtilisin/kexin type 9 preproprotein
, Proprotein convertase 9
, Subtilisin/kexin-like protease PC9