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Proprotein Convertase Subtilisin/kexin Type 9 Proteins (PCSK9)

PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. Additionally we are shipping PCSK9 Antibodies (161) and PCSK9 Kits (54) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PCSK9 255738 Q8NBP7
PCSK9 100102 Q80W65
PCSK9 298296 P59996
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Top PCSK9 Proteins at antibodies-online.com

Showing 10 out of 55 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Rat His tag 50 μg Log in to see 2 to 3 Days
$286.00
Details
HOST_Human Cells Rat His tag 10 μg Log in to see 16 Days
$228.80
Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 16 Days
$228.80
Details
HOST_Human Cells Rhesus Monkey His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_HEK-293 Cells Human Strep Tag 25 μg Log in to see 2 to 3 Days
$286.00
Details
HOST_HEK-293 Cells Mouse His tag 100 μg Log in to see 2 to 3 Days
$308.00
Details
HOST_HEK-293 Cells Human His tag 200 μg Log in to see 21 to 31 Days
$1,320.00
Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$547.80
Details
HOST_HEK-293 Mouse His tag 20 μg Log in to see 2 to 3 Days
$325.50
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

PCSK9 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
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Mouse (Murine) , , ,
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Rat (Rattus) , , , ,

Top referenced PCSK9 Proteins

  1. Mouse (Murine) PCSK9 Protein expressed in Human Cells - ABIN2007572 : Qian, Schmidt, Zhang, Chu, Lin, Wang, Wang, Beyer, Bensch, Li, Ehsani, Lu, Konrad, Eacho, Moller, Karathanasis, Cao: Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. in Journal of lipid research 2007 (PubMed)
    Show all 5 references for ABIN2007572

  2. Rhesus Monkey PCSK9 Protein expressed in Human Cells - ABIN2003817 : Shan, Pang, Zhang, Murgolo, Lan, Hedrick: PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 4 references for ABIN2003817

  3. Rat (Rattus) PCSK9 Protein expressed in Human Cells - ABIN2009013 : Benjannet, Rhainds, Essalmani, Mayne, Wickham, Jin, Asselin, Hamelin, Varret, Allard, Trillard, Abifadel, Tebon, Attie, Rader, Boileau, Brissette, Chrétien, Prat, Seidah: NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. in The Journal of biological chemistry 2004 (PubMed)
    Show all 4 references for ABIN2009013

  4. Human PCSK9 Protein expressed in Human Cells - ABIN3216386 : Abifadel, Varret, Rabès, Allard, Ouguerram, Devillers, Cruaud, Benjannet, Wickham, Erlich, Derré, Villéger, Farnier, Beucler, Bruckert, Chambaz, Chanu, Lecerf, Luc, Moulin, Weissenbach, Prat, Krempf et al.: Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. ... in Nature genetics 2003 (PubMed)
    Show all 4 references for ABIN3216386

  5. Human PCSK9 Protein expressed in HEK-293 Cells - ABIN2487350 : Seidah, Benjannet, Wickham, Marcinkiewicz, Jasmin, Stifani, Basak, Prat, Chretien: The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
    Show all 2 references for ABIN2487350

More Proteins for Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Interaction Partners

Human Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. PCSK9 could serve as a novel molecular biomarker for the non-invasive prenatal screening of neural tube defects.

  2. the current meta-analysis highlighted that variant allele of OLR1 (show OLR1 Proteins) rs11053646 G > C and PCSK9 rs505151 A > G may contribute to the susceptibility risk of ischemic stroke.

  3. Polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating PCSK9

  4. These data demonstrate that serum Lp(a (show APOA Proteins)) is elevated in patients with FH caused by PCSK9 gain-of-function mutations to the same level as that in FH caused by LDLR (show LDLR Proteins) mutations.

  5. study demonstrated that patients with differentiated thyroid cancer both before and after thyroid hormone (show PTH Proteins) withdrawal which is a hypothyroid phase, had increased proprotein convertase subtilisin/kexin type 9 levels and decreased ankle brachial index

  6. No correlation between baseline levels of plasma PCSK9 and the fatty acid content of marine n-3 PUFA in adipose tissue.

  7. PCSK9 GOF mutation carriers have elevated LDL-C levels and are at high risk of premature cardiovascular disease.

  8. Familial hypercholesterolemia individuals carry the PCSK9-InsLEU genetic variant benefit of lower risk of coronary events but show an increased occurrence of prediabetes and diabetes

  9. Alirocumab is a fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9.

  10. Data suggest plasma levels of PCSK9 (proprotein convertase subtilisin/kexin type 9) and lipoprotein(a) are significantly up-regulated in patients with type 2 diabetes as compared to control subject; study was conducted in Tunisia.

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating PCSK9.

  2. binding of PCSK9 to GRP94 (show HSP90B1 Proteins) protects LDLR (show LDLR Proteins) from degradation likely by preventing early binding of PCSK9 to LDLR (show LDLR Proteins)

  3. The absence of PCSK9 results in a sex- and tissue-specific subcellular distribution of the LDLR (show LDLR Proteins) and VLDLR (show VLDLR Proteins), which is determined by estradiol levels.

  4. that ox-LDL receptor-1 (show OLR1 Proteins) and PCSK9 positively influence each other's expression, especially during an inflammatory reaction

  5. Data show that leptin (show LEP Proteins) treatment suppresses proprotein convertase subtilisin/kexin type 9 (PCSK9) in male, but fails to suppress PCSK9 in female.

  6. The Liver Clock Controls Cholesterol Homeostasis through Trib1 (show TRIB1 Proteins) Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR (show LDLR Proteins)) Axis.

  7. Hepatic LDLR (show LDLR Proteins) levels are up-regulated in SEC24A (show SEC24A Proteins)-deficient cells as a consequence of specific dependence of PCSK9, a negative regulator of LDLR (show LDLR Proteins), on SEC24A (show SEC24A Proteins) for efficient exit from the ensoplasmic reticulum.

  8. PCSK9(-/-) mice display normal sodium balance and blood pressure regulation despite an increase of cleaved alphaENaC (show SCNN1A Proteins) under basal condition

  9. PCSK9-mediated CD36 (show CD36 Proteins) degradation may serve to limit fatty acid uptake and triglyceride accumulation in tissues, such as the liver and adipose tissue.

  10. HNF1alpha (show HNF1A Proteins), but not HNF1beta (show HNF1B Proteins), is the primary positive regulator of PCSK9 transcription in mouse liver

PCSK9 Protein Profile

Protein Summary

This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Gene names and symbols associated with PCSK9

  • proprotein convertase subtilisin/kexin type 9 (pcsk9)
  • proprotein convertase subtilisin/kexin type 9 (PCSK9)
  • proprotein convertase subtilisin/kexin type 9 (Pcsk9)
  • proprotein convertase subtilisin/kexin type 9-like (LOC100620501)
  • AI415265 protein
  • AI747682 protein
  • FH3 protein
  • HCHOLA3 protein
  • LDLCQ1 protein
  • NARC-1 protein
  • Narc1 protein
  • PC9 protein

Protein level used designations for PCSK9

proprotein convertase subtilisin/kexin type 9 , convertase subtilisin/kexin type 9 preproprotein , neural apoptosis regulated convertase 1 , subtilisin/kexin-like protease PC9 , NARC-1 , convertase subtilisin , neural apoptosis-regulated convertase 1 , proprotein convertase 9 , proprotein convertase PC9 , proprotein convertase subtilisin/kexin type 9 preproprotein , Proprotein convertase 9 , Subtilisin/kexin-like protease PC9

GENE ID SPECIES
495509 Xenopus laevis
100150316 Danio rerio
100544916 Meleagris gallopavo
255738 Homo sapiens
100102 Mus musculus
298296 Rattus norvegicus
424664 Gallus gallus
100731533 Cavia porcellus
717147 Macaca mulatta
100971792 Pan paniscus
456880 Pan troglodytes
100395116 Callithrix jacchus
100620501 Sus scrofa
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