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Proprotein Convertase Subtilisin/kexin Type 9 Proteins (PCSK9)

PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. Additionally we are shipping PCSK9 Antibodies (152) and PCSK9 Kits (56) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PCSK9 255738 Q8NBP7
PCSK9 100102 Q80W65
PCSK9 298296 P59996
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Top PCSK9 Proteins at antibodies-online.com

Showing 10 out of 61 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Rat His tag Rat PCSK9, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 97%. 50 μg Log in to see 2 to 3 Days
$286.00
Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 16 Days
$228.80
Details
HOST_Human Cells Rat His tag 10 μg Log in to see 16 Days
$228.80
Details
HOST_Human Cells Rhesus Monkey His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_HEK-293 Cells Human His tag Human PCSK9 (D374Y), His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%. Immobilized Human LDL R, His Tag (Cat# LDR-H5224) at 10 μg/mL (100 μl/well) can bind Human PCSK9 (D374Y), His Tag (Cat# PCY-H5225 ) with a linear range of 5-50 ng/mL. 50 μg Log in to see 2 to 3 Days
$286.00
Details
HOST_HEK-293 Cells Mouse His tag Mouse PCSK9, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 97%. Immobilized Human LDL R, Strep Tag (Cat# LDR-H5281) at 10 μg/mL (100 μl/well) can bind Mouse PCSK9, His Tag (Cat# PC9-M5228 ) with a linear range of 2-30 ng/mL. 100 μg Log in to see 2 to 3 Days
$308.00
Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$547.80
Details
HOST_HEK-293 Mouse His tag 20 μg Log in to see 2 to 3 Days
$336.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_CHO Cells Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$206.55
Details

PCSK9 Proteins by Origin and Source

Origin Expressed in Conjugate
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Mouse (Murine) , , , , ,
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Rat (Rattus) , , , ,
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Top referenced PCSK9 Proteins

  1. Mouse (Murine) PCSK9 Protein expressed in Human Cells - ABIN2007572 : Qian, Schmidt, Zhang, Chu, Lin, Wang, Wang, Beyer, Bensch, Li, Ehsani, Lu, Konrad, Eacho, Moller, Karathanasis, Cao: Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. in Journal of lipid research 2007 (PubMed)
    Show all 5 references for ABIN2007572

  2. Human PCSK9 Protein expressed in CHO Cells - ABIN2666529 : Costet, Krempf, Cariou: PCSK9 and LDL cholesterol: unravelling the target to design the bullet. in Trends in biochemical sciences 2008 (PubMed)
    Show all 4 references for ABIN2666529

  3. Rhesus Monkey PCSK9 Protein expressed in Human Cells - ABIN2003817 : Shan, Pang, Zhang, Murgolo, Lan, Hedrick: PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 4 references for ABIN2003817

  4. Rat (Rattus) PCSK9 Protein expressed in Human Cells - ABIN2009013 : Benjannet, Rhainds, Essalmani, Mayne, Wickham, Jin, Asselin, Hamelin, Varret, Allard, Trillard, Abifadel, Tebon, Attie, Rader, Boileau, Brissette, Chrétien, Prat, Seidah: NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. in The Journal of biological chemistry 2004 (PubMed)
    Show all 4 references for ABIN2009013

  5. Human PCSK9 Protein expressed in Human Cells - ABIN3216386 : Abifadel, Varret, Rabès, Allard, Ouguerram, Devillers, Cruaud, Benjannet, Wickham, Erlich, Derré, Villéger, Farnier, Beucler, Bruckert, Chambaz, Chanu, Lecerf, Luc, Moulin, Weissenbach, Prat, Krempf et al.: Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. ... in Nature genetics 2003 (PubMed)
    Show all 4 references for ABIN3216386

  6. Human PCSK9 Protein expressed in HEK-293 Cells - ABIN2181588 : Seidah, Benjannet, Wickham, Marcinkiewicz, Jasmin, Stifani, Basak, Prat, Chretien: The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
    Show all 2 references for ABIN2181588

More Proteins for Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Interaction Partners

Human Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. Both PCSK9 levels and CETP (show CETP Proteins) activity were higher in patients with an increasing number of metabolic syndrome components

  2. Circulating PCSK9 levels were correlated with an atherogenic lipid profile and with insulin (show INS Proteins) resistance parameters; The rs11591147 genetic variant of PCSK9 resulted in lower levels of circulating PCSK9 and LDL cholesterol

  3. PCSK9 increases hepatic lipid and lipoprotein production via apoE (show APOE Proteins)- and LDLR (show LDLR Proteins)-dependent mechanisms

  4. Possible inter-locus interactions among the DOCK7, PCSK9 and GALNT2 (show GALNT2 Proteins) SNPs were also noted.

  5. In this study, variants in PCSK9 had approximately the same effect as variants in HMGCR (show HMGCR Proteins) on the risk of cardiovascular events and diabetes per unit decrease in the LDL cholesterol level. The effects of these variants were independent and additive.

  6. During sepsis, PCSK9 levels are highly correlated with the development of subsequent multiple organ failure. Inhibition of PCSK9 activity is an attractive target for treating the spectrum of sepsis and septic shock.

  7. Report increased intestinal cholesterol absorption and elevated serum cholesterol in families with primary hypercholesterolemia without mutations in PCSK9.

  8. Serum PCSK9 level is significantly elevated in coronary heart disease patients.

  9. These data suggest that serum levels of PCSK9 may contribute to increased risk of subclinical carotid atherosclerosis independent of conventional risk factors.

  10. Differences in lipid profiles between the Jing and Han populations might partially attribute to the DOCK7, PCSK9 and GALNT2 (show GALNT2 Proteins) gene polymorphisms and their haplotypes determining different risk for the development of cardiovascular diseases.

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. PCSK9 increases hepatic lipid and lipoprotein production via apoE (show APOE Proteins)- and LDLR (show LDLR Proteins)-dependent mechanisms

  2. Podocyte damage triggers marked inductions in plasma PCSK9, and knockout of Pcsk9 ameliorates dyslipidemia in a mouse model of nephrotic syndrome.

  3. polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating PCSK9.

  4. binding of PCSK9 to GRP94 (show HSP90B1 Proteins) protects LDLR (show LDLR Proteins) from degradation likely by preventing early binding of PCSK9 to LDLR (show LDLR Proteins)

  5. The absence of PCSK9 results in a sex- and tissue-specific subcellular distribution of the LDLR (show LDLR Proteins) and VLDLR (show VLDLR Proteins), which is determined by estradiol levels.

  6. that ox-LDL receptor-1 (show OLR1 Proteins) and PCSK9 positively influence each other's expression, especially during an inflammatory reaction

  7. Data show that leptin (show LEP Proteins) treatment suppresses proprotein convertase subtilisin/kexin type 9 (PCSK9) in male, but fails to suppress PCSK9 in female.

  8. The Liver Clock Controls Cholesterol Homeostasis through Trib1 (show TRIB1 Proteins) Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR (show LDLR Proteins)) Axis.

  9. Hepatic LDLR (show LDLR Proteins) levels are up-regulated in SEC24A (show SEC24A Proteins)-deficient cells as a consequence of specific dependence of PCSK9, a negative regulator of LDLR (show LDLR Proteins), on SEC24A (show SEC24A Proteins) for efficient exit from the ensoplasmic reticulum.

  10. PCSK9(-/-) mice display normal sodium balance and blood pressure regulation despite an increase of cleaved alphaENaC (show SCNN1A Proteins) under basal condition

PCSK9 Protein Profile

Protein Summary

This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Gene names and symbols associated with PCSK9

  • proprotein convertase subtilisin/kexin type 9 (pcsk9)
  • proprotein convertase subtilisin/kexin type 9 (PCSK9)
  • proprotein convertase subtilisin/kexin type 9 (Pcsk9)
  • proprotein convertase subtilisin/kexin type 9-like (LOC100620501)
  • AI415265 protein
  • AI747682 protein
  • FH3 protein
  • HCHOLA3 protein
  • LDLCQ1 protein
  • NARC-1 protein
  • Narc1 protein
  • PC9 protein

Protein level used designations for PCSK9

proprotein convertase subtilisin/kexin type 9 , convertase subtilisin/kexin type 9 preproprotein , neural apoptosis regulated convertase 1 , subtilisin/kexin-like protease PC9 , NARC-1 , convertase subtilisin , neural apoptosis-regulated convertase 1 , proprotein convertase 9 , proprotein convertase PC9 , proprotein convertase subtilisin/kexin type 9 preproprotein , Proprotein convertase 9 , Subtilisin/kexin-like protease PC9

GENE ID SPECIES
495509 Xenopus laevis
100150316 Danio rerio
100544916 Meleagris gallopavo
255738 Homo sapiens
100102 Mus musculus
298296 Rattus norvegicus
424664 Gallus gallus
100731533 Cavia porcellus
717147 Macaca mulatta
100971792 Pan paniscus
456880 Pan troglodytes
100395116 Callithrix jacchus
100620501 Sus scrofa
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