Proprotein Convertase Subtilisin/kexin Type 9 Proteins (PCSK9)

PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. Additionally we are shipping PCSK9 Antibodies (153) and PCSK9 Kits (72) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PCSK9 255738 Q8NBP7
PCSK9 100102 Q80W65
PCSK9 298296 P59996
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Top PCSK9 Proteins at antibodies-online.com

Showing 10 out of 60 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 20 to 21 Days
$228.80
Details
HOST_HEK-293 Cells Rat His tag Rat PCSK9, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 97%. 50 μg Log in to see 2 to 3 Days
$286.00
Details
HOST_Human Cells Rat His tag 10 μg Log in to see 20 to 21 Days
$228.80
Details
HOST_Human Cells Rhesus Monkey His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_HEK-293 Cells Human Strep Tag Human PCSK9, Strep Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 97%. 25 μg Log in to see 2 to 3 Days
$286.00
Details
HOST_HEK-293 Cells Mouse His tag Mouse PCSK9, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 97%. Immobilized Human LDL R, Strep Tag (Cat# LDR-H5281) at 10 μg/mL (100 μl/well) can bind Mouse PCSK9, His Tag (Cat# PC9-M5228 ) with a linear range of 2-30 ng/mL. 100 μg Log in to see 2 to 3 Days
$308.00
Details
HOST_Human Cells Human His tag 50 μg Log in to see 20 to 21 Days
$547.80
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_CHO Cells Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$206.55
Details
HOST_HEK-293 Mouse Un-conjugated   10 μg Log in to see 10 to 12 Days
$206.55
Details

PCSK9 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , , ,
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Mouse (Murine) , , , , , ,
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Rat (Rattus) , , , ,
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Top referenced PCSK9 Proteins

  1. Mouse (Murine) PCSK9 Protein expressed in HEK-293 - ABIN2666714 : Denis, Marcinkiewicz, Zaid, Gauthier, Poirier, Lazure, Seidah, Prat: Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice. in Circulation 2012 (PubMed)
    Show all 7 references for 2666714

  2. Mouse (Murine) PCSK9 Protein expressed in Human Cells - ABIN2007572 : Qian, Schmidt, Zhang, Chu, Lin, Wang, Wang, Beyer, Bensch, Li, Ehsani, Lu, Konrad, Eacho, Moller, Karathanasis, Cao: Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. in Journal of lipid research 2007 (PubMed)
    Show all 5 references for 2007572

  3. Human PCSK9 Protein expressed in CHO Cells - ABIN2666529 : Costet, Krempf, Cariou: PCSK9 and LDL cholesterol: unravelling the target to design the bullet. in Trends in biochemical sciences 2008 (PubMed)
    Show all 4 references for 2666529

  4. Rat (Rattus) PCSK9 Protein expressed in Human Cells - ABIN2009013 : Shan, Pang, Zhang, Murgolo, Lan, Hedrick: PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 4 references for 2009013

  5. Human PCSK9 Protein expressed in Human Cells - ABIN3216386 : Benjannet, Rhainds, Essalmani, Mayne, Wickham, Jin, Asselin, Hamelin, Varret, Allard, Trillard, Abifadel, Tebon, Attie, Rader, Boileau, Brissette, Chrétien, Prat, Seidah: NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. in The Journal of biological chemistry 2004 (PubMed)
    Show all 4 references for 3216386

  6. Rhesus Monkey PCSK9 Protein expressed in Human Cells - ABIN2003817 : Abifadel, Varret, Rabès, Allard, Ouguerram, Devillers, Cruaud, Benjannet, Wickham, Erlich, Derré, Villéger, Farnier, Beucler, Bruckert, Chambaz, Chanu, Lecerf, Luc, Moulin, Weissenbach, Prat, Krempf et al.: Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. ... in Nature genetics 2003 (PubMed)
    Show all 4 references for 2003817

  7. Human PCSK9 Protein expressed in HEK-293 Cells - ABIN2181583 : Seidah, Benjannet, Wickham, Marcinkiewicz, Jasmin, Stifani, Basak, Prat, Chretien: The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
    Show all 2 references for 2181583

More Proteins for Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Interaction Partners

Human Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. these studies support that reductions in Lp(a (show APOA Proteins)) with PCSK9 inhibition are partly due to increased LDLR (show LDLR Proteins)-mediated uptake. In most situations, Lp(a (show APOA Proteins)) appears to compete poorly with LDL for LDLR (show LDLR Proteins) binding and internalization, but when LDLR (show LDLR Proteins) expression is increased with evolocumab, particularly in the setting of low circulating LDL, Lp(a (show APOA Proteins)) is reduced.

  2. Plasma levels of proprotein convertase subtilisin/kexin type 9 (PCSK9), apolipoprotein C-III (apoC3 (show APOC3 Proteins)) and small dense low density lipoprotein cholesterol (sdLDL-C) showed significant interactions with current dyslipidemias, and were predictive in the screening.

  3. Some loss of function variants in PCSK9 are associated with enhanced LDL cholesterol lowering response to statin therapy.

  4. These observations suggest positive feedback interplay between SMC (show DYM Proteins)-derived PCSK9 and mtDNA damage in the proinflammatory milieu involving mtROS. This interaction results in cellular injury, characterized by apoptosis-a hallmark of atherosclerosis.

  5. PCSK9 level is not associated with systolic or diastolic blood pressure in hypertensives or normotensives, but it positively correlates with carotid intima-media thickness in hypertensives in univariate but not multivariate analyses, and further researches are needed.

  6. results reveal that the tanshinone IIA modulates LDLR (show LDLR Proteins) level and activity via down-regulation of PCSK9 expression in hepatic cells

  7. This article reviews the functions and regulatory mechanisms of PCSK9. The effects of PCSK9 on the LDL receptor (show LDLR Proteins), the relationship of this convertase with IDOL (show MYLIP Proteins), and treatments currently available against hypercholesterolemia are also discussed. [review]

  8. LC n-3 PUFA intake is associated with a lower risk of nonfatal MI in C-allele carriers of PCSK9 rs11206510 (n = 799) but not in non-C-allele carriers (n = 3188).

  9. the zymogen form of PCSK9 adopts a structure that is distinct from the processed form and is unable to bind a mimetic peptide based on the EGF (show EGF Proteins)-A domain of the LDLr (show LDLR Proteins).

  10. CRP (show CRP Proteins) increased PCSK9 expression by activating p38MAPK (show MAPK14 Proteins)-HNF1alpha (show HNF1A Proteins) pathway, with a certain downstream impairment in LDL metabolism in HepG2 cells.

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) interaction partners

  1. These observations suggest positive feedback interplay between SMC (show DYM Proteins)-derived PCSK9 and mtDNA damage in the proinflammatory milieu involving mtROS. This interaction results in cellular injury, characterized by apoptosis-a hallmark of atherosclerosis.

  2. AdipoR activation by agonists regulated PCSK9 expression and inhibits atherosclerosis in apoE (show APOE Proteins)(-/-) mice.

  3. Adeno (show ADORA2A Proteins)-associated virus mediated infection with a mouse PCSK9 gain-of-function mutation is a rapid, easy, and efficient approach for inducing hypercholesterolemia and promoting abdominal aortic aneurysms in C57BL/6 mice infused with angiotensin II.

  4. conditions that cause ER stress regardless of their ability to dysregulate ER Ca(2 (show CA2 Proteins)+) inhibit PCSK9 secretion, thereby reducing PCSK9-mediated LDLR (show LDLR Proteins) degradation and promoting LDLR (show LDLR Proteins)-dependent hepatic cholesterol uptake.

  5. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor (show LDLR Proteins) Degradation.

  6. PCSK9 increases hepatic lipid and lipoprotein production via apoE (show APOE Proteins)- and LDLR (show LDLR Proteins)-dependent mechanisms

  7. Podocyte damage triggers marked inductions in plasma PCSK9, and knockout of Pcsk9 ameliorates dyslipidemia in a mouse model of nephrotic syndrome.

  8. polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating PCSK9.

  9. binding of PCSK9 to GRP94 (show HSP90B1 Proteins) protects LDLR (show LDLR Proteins) from degradation likely by preventing early binding of PCSK9 to LDLR (show LDLR Proteins)

  10. The absence of PCSK9 results in a sex- and tissue-specific subcellular distribution of the LDLR (show LDLR Proteins) and VLDLR (show VLDLR Proteins), which is determined by estradiol levels.

PCSK9 Protein Profile

Protein Summary

This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Gene names and symbols associated with PCSK9

  • proprotein convertase subtilisin/kexin type 9 (pcsk9)
  • proprotein convertase subtilisin/kexin type 9 (PCSK9)
  • proprotein convertase subtilisin/kexin type 9 (Pcsk9)
  • proprotein convertase subtilisin/kexin type 9-like (LOC100620501)
  • AI415265 protein
  • AI747682 protein
  • FH3 protein
  • HCHOLA3 protein
  • LDLCQ1 protein
  • NARC-1 protein
  • Narc1 protein
  • PC9 protein

Protein level used designations for PCSK9

proprotein convertase subtilisin/kexin type 9 , convertase subtilisin/kexin type 9 preproprotein , neural apoptosis regulated convertase 1 , subtilisin/kexin-like protease PC9 , NARC-1 , convertase subtilisin , neural apoptosis-regulated convertase 1 , proprotein convertase 9 , proprotein convertase PC9 , proprotein convertase subtilisin/kexin type 9 preproprotein , Proprotein convertase 9 , Subtilisin/kexin-like protease PC9

GENE ID SPECIES
495509 Xenopus laevis
100150316 Danio rerio
100544916 Meleagris gallopavo
255738 Homo sapiens
100102 Mus musculus
298296 Rattus norvegicus
424664 Gallus gallus
100731533 Cavia porcellus
717147 Macaca mulatta
100971792 Pan paniscus
456880 Pan troglodytes
100395116 Callithrix jacchus
100620501 Sus scrofa
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