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anti-Prosaposin (PSAP) Antibodies

PSAP encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Additionally we are shipping Prosaposin Kits (37) and Prosaposin Proteins (20) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PSAP 56462 Q791T5
PSAP 5660 P07602
PSAP 25524 P10960
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Top anti-Prosaposin Antibodies at antibodies-online.com

Showing 10 out of 105 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of SAP Antibody (Center E300) in Y79,A2058,CEM cell line lysates(35ug/lane). SAP (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from NIH-3T3/RAW264.7 cells, using PSAP Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated ICC, FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of HeLa cells using PSAP mouse mAb (green) and negative control (purple) . 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Mouse Rabbit Un-conjugated IHC, WB Immunofluorescence analysis of MCF7 cell using PSAP antibody. Blue: DAPI for nuclear staining. 100 μL Log in to see 9 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: Molt-4 , 7.5% SDS PAGE antibody diluted at 1:2000 IHC-P Image Immunohistochemical analysis of paraffin-embedded NCIN87 xenograft , using PSAP, antibody at 1:500 dilution. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Mouse Un-conjugated IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to PSAP on formalin-fixed paraffin-embedded human spleen tissue. [antibody concentration 5 ug/ml] Western Blot analysis of PSAP expression in transfected 293T cell line by PSAP monoclonal antibody (M01), clone 1D1-C12.Lane 1: PSAP transfected lysate(58.1 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated EIA, IHC (p), IP, WB 50 μg Log in to see 6 to 8 Days
$566.50
Details
Human Mouse Un-conjugated ICC, FACS, IF, IHC (p), ELISA, WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to PSAP on formalin-fixed paraffin-embedded human spleen tissue (antibody concentration 5 µg/mL). 0.1 mg Log in to see 8 to 11 Days
$450.00
Details

PSAP Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Prosaposin Antibodies

  1. Mouse (Murine) Polyclonal Prosaposin Primary Antibody for IHC, WB - ABIN3022606 : OBrien, Kishimoto: Saposin proteins: structure, function, and role in human lysosomal storage disorders. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991 (PubMed)
    Show all 3 references for ABIN3022606

  2. Human Polyclonal Prosaposin Primary Antibody for EIA, WB - ABIN453360 : Kuchar, Ledvinová, Hrebícek, Mysková, Dvoráková, Berná, Chrastina, Asfaw, Elleder, Petermöller, Mayrhofer, Staudt, Krägeloh-Mann, Paton, Harzer: Prosaposin deficiency and saposin B deficiency (activator-deficient metachromatic leukodystrophy): report on two patients detected by analysis of urinary sphingolipids and carrying novel PSAP gene mutations. in American journal of medical genetics. Part A 2009 (PubMed)
    Show all 2 references for ABIN453360

  3. Human Monoclonal Prosaposin Primary Antibody for ICC, FACS - ABIN1098150 : Xu, Deng, Mao, Zhang, Wang, Wang, Mu, Deng, Ma: The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells. in The Biochemical journal 2011 (PubMed)
    Show all 2 references for ABIN1098150

  4. Human Monoclonal Prosaposin Primary Antibody for IHC (p), IP - ABIN562465 : Koochekpour, Hu, Vellasco-Gonzalez, Bernardo, Azabdaftari, Zhu, Zhau, Chung, Vessella: Serum prosaposin levels are increased in patients with advanced prostate cancer. in The Prostate 2012 (PubMed)

  5. Human Polyclonal Prosaposin Primary Antibody for ELISA, WB - ABIN1535203 : Rorman, Grabowski: Molecular cloning of a human co-beta-glucosidase cDNA: evidence that four sphingolipid hydrolase activator proteins are encoded by single genes in humans and rats. in Genomics 1990 (PubMed)

More Antibodies against Prosaposin Interaction Partners

Zebrafish Prosaposin (PSAP) interaction partners

Mouse (Murine) Prosaposin (PSAP) interaction partners

  1. Data suggested that the abundance of Psap in sperm sample may be a sensitive endpoint to predict PCB (show PC Antibodies) exposure.

  2. Prosaposin facilitates sortilin (show SORT1 Antibodies)-independent lysosomal trafficking of progranulin (show GRN Antibodies).

  3. Mesotrypsin (show PRSS3 Antibodies) generated saposins A-D from prosaposin, and mature caspase-14 (show CASP14 Antibodies) contributed to this process by activating mesotrypsinogen (show PRSS3 Antibodies) to mesotrypsin (show PRSS3 Antibodies). Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.

  4. Low levels of prosaposin and its receptors in the mouse brain suggest the participation of prosaponin in pathological changes in the brains of dystrophic mdx (show DMD Antibodies) mice.

  5. These data show functional association between GPR37, prosaposin, and GM1 ganglioside in the plasma membrane.

  6. Prosaposin is involved in the regulation of muscle differentiation of regenerated fibres

  7. Saposins A and B deficiencies attenuated GalCer-beta-galactosylceramidase (show GALC Antibodies) and GM1-beta-galactosidase (show GLB1 Antibodies) functions in the degradation of lactosylceramide in the liver.

  8. These data suggest that prosaposin plays an important role in the neuronal maturation processes of the vestibular sensory epithelium and the maintenance of normal vestibular system function.

  9. The saposin C deficient mice backcrossed to point mutated GCase (show GBA Antibodies) mimics the central nervous system phenotype and biochemistry of some type 3 (neuronopathic) variants of Gaucher disease.

  10. UGT1 aids in the folding of sequential domain-containing proteins such as prosaposin.

Human Prosaposin (PSAP) interaction partners

  1. Our findings suggest a novel pharmacological approach to Sap (show APCS Antibodies) C deficiency directed to treat major secondary pathological aspects in this disorder.

  2. PSAP is a secreted biomarker.

  3. Data suggested that the abundance of Psap in sperm sample may be a sensitive endpoint to predict PCB (show PC Antibodies) exposure.

  4. Prosaposin facilitates sortilin (show SORT1 Antibodies)-independent lysosomal trafficking of progranulin (show GRN Antibodies).

  5. findings support a lung metastasis-promoting function of the miR (show MLXIP Antibodies)-23b/27b/24 cluster of miRNAs, which functions in part through the direct inhibition of PSAP in breast cancer

  6. Mesotrypsin (show PRSS3 Antibodies) generated saposins A-D from prosaposin, and mature caspase-14 (show CASP14 Antibodies) contributed to this process by activating mesotrypsinogen (show PRSS3 Antibodies) to mesotrypsin (show PRSS3 Antibodies). Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.

  7. Of the 2575 proteins identified, proteins upregulated in gallbladder cancer included several lysosomal proteins such as prosaposin, cathepsin Z (show CTSZ Antibodies) and cathepsin H (show CTSH Antibodies).

  8. Saposin C protects glucocerebrosidase (show GBA Antibodies) against alpha-synuclein (show SNCA Antibodies) inhibition.

  9. Urine of patients with early prostate cancer contains lower levels of light chain fragments of inter-alpha-trypsin inhibitor and prosaposin fragment or saposin B.

  10. These findings suggested that prosaposin might enhance estrogen receptor alpha (show ESR1 Antibodies)-mediated signaling axis and play a role in breast cancer development and progression.

Pig (Porcine) Prosaposin (PSAP) interaction partners

  1. identified 68 single-nucleotide polymorphisms and 9 indels in the pig PASP (show CPB1 Antibodies) gene, and three single-nucleotide polymorphisms were nonsynonymous substitutions

  2. Saposin B (Sap (show APCS Antibodies) B) is not a limiting factor of the coupled Sap (show APCS Antibodies) B-arylsulfatase A (show ARSA Antibodies) reaction in mouse kidney cells even if sulfatide has accumulated to unphysiologically high levels.

Prosaposin (PSAP) Antigen Profile

Protein Summary

This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with anti-Prosaposin (PSAP) Antibodies

  • prosaposin (psap) antibody
  • prosaposin (PSAP) antibody
  • prosaposin (LOC100304726) antibody
  • prosaposin (LOC100526719) antibody
  • mitochondrial carrier homolog 1 (C. elegans) (Mtch1) antibody
  • prosaposin (Psap) antibody
  • prosaposin (LOC100359322) antibody
  • surfactant protein A1 (Sftpa1) antibody
  • 2310034O17Rik antibody
  • AI037048 antibody
  • AI255158 antibody
  • AU018396 antibody
  • C77849 antibody
  • cb759 antibody
  • GLBA antibody
  • PSAP antibody
  • SAP1 antibody
  • Sftp1 antibody
  • Sftpa antibody
  • Sftpl antibody
  • SGP-1 antibody
  • SGP1A antibody
  • SP-A antibody
  • wu:fa14a06 antibody
  • wu:fb36e02 antibody
  • wu:fb58g07 antibody

Protein level used designations for anti-Prosaposin (PSAP) Antibodies

prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) , prosaposin , proactivator polypeptide-like , mitochondrial carrier homolog 1 , mitochondrial carrier-like protein 1 , proactivator polypeptide , sphingolipid activator protein-1 , snoRNA MBII-198 , sulfated glycoprotein 1 , prosaposin (sulfated glycoprotein, sphingolipid hydrolase activator) , PSAP , PSP-A , Surfactant-associated protein 1 (pulmonary surfactant protein SP-A) , Surfactant-associated protein 1 (pulmonary surfactant protein, SP-A) , pulmonary surfactant-associated protein A , surfactant associated protein A , surfactant, pulmonary-associated protein A1

GENE ID SPECIES
140811 Danio rerio
450517 Pan troglodytes
709510 Macaca mulatta
100011417 Monodelphis domestica
100304726 Ictalurus punctatus
100399482 Callithrix jacchus
100526719 Ictalurus punctatus
100593695 Nomascus leucogenys
56462 Mus musculus
5660 Homo sapiens
19156 Mus musculus
25524 Rattus norvegicus
100359322 Oryctolagus cuniculus
100713024 Cavia porcellus
100153167 Sus scrofa
281433 Bos taurus
395602 Gallus gallus
479240 Canis lupus familiaris
100135695 Ovis aries
24773 Rattus norvegicus
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