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PSAP encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Additionally we are shipping Prosaposin Kits (29) and Prosaposin Proteins (20) and many more products for this protein.
Showing 10 out of 107 products:
Mouse (Murine) Polyclonal Prosaposin Primary Antibody for IHC, WB - ABIN3022606
OBrien, Kishimoto: Saposin proteins: structure, function, and role in human lysosomal storage disorders. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991
Show all 3 references for ABIN3022606
Human Polyclonal Prosaposin Primary Antibody for EIA, WB - ABIN453360
Kuchar, Ledvinová, Hrebícek, Mysková, Dvoráková, Berná, Chrastina, Asfaw, Elleder, Petermöller, Mayrhofer, Staudt, Krägeloh-Mann, Paton, Harzer: Prosaposin deficiency and saposin B deficiency (activator-deficient metachromatic leukodystrophy): report on two patients detected by analysis of urinary sphingolipids and carrying novel PSAP gene mutations. in American journal of medical genetics. Part A 2009
Show all 2 references for ABIN453360
Human Monoclonal Prosaposin Primary Antibody for ICC, FACS - ABIN1098150
Xu, Deng, Mao, Zhang, Wang, Wang, Mu, Deng, Ma: The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells. in The Biochemical journal 2011
Show all 2 references for ABIN1098150
Human Monoclonal Prosaposin Primary Antibody for IHC (p), IP - ABIN562465
Koochekpour, Hu, Vellasco-Gonzalez, Bernardo, Azabdaftari, Zhu, Zhau, Chung, Vessella: Serum prosaposin levels are increased in patients with advanced prostate cancer. in The Prostate 2012
Human Polyclonal Prosaposin Primary Antibody for ELISA, WB - ABIN1535203
Rorman, Grabowski: Molecular cloning of a human co-beta-glucosidase cDNA: evidence that four sphingolipid hydrolase activator proteins are encoded by single genes in humans and rats. in Genomics 1990
Data suggested that the abundance of Psap in sperm sample may be a sensitive endpoint to predict PCB (show PC Antibodies) exposure.
Prosaposin facilitates sortilin (show SORT1 Antibodies)-independent lysosomal trafficking of progranulin (show GRN Antibodies).
Mesotrypsin (show PRSS3 Antibodies) generated saposins A-D from prosaposin, and mature caspase-14 (show CASP14 Antibodies) contributed to this process by activating mesotrypsinogen (show PRSS3 Antibodies) to mesotrypsin (show PRSS3 Antibodies). Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.
Low levels of prosaposin and its receptors in the mouse brain suggest the participation of prosaponin in pathological changes in the brains of dystrophic mdx (show DMD Antibodies) mice.
These data show functional association between GPR37, prosaposin, and GM1 ganglioside in the plasma membrane.
Prosaposin is involved in the regulation of muscle differentiation of regenerated fibres
Saposins A and B deficiencies attenuated GalCer-beta-galactosylceramidase (show GALC Antibodies) and GM1-beta-galactosidase (show GLB1 Antibodies) functions in the degradation of lactosylceramide in the liver.
These data suggest that prosaposin plays an important role in the neuronal maturation processes of the vestibular sensory epithelium and the maintenance of normal vestibular system function.
The saposin C deficient mice backcrossed to point mutated GCase (show GBA Antibodies) mimics the central nervous system phenotype and biochemistry of some type 3 (neuronopathic) variants of Gaucher disease.
UGT1 aids in the folding of sequential domain-containing proteins such as prosaposin.
an extensive review of all the PSAP-causative variants published in the literature to date, accounting for a total of 10 PSAP allele types (review)
Our findings suggest a novel pharmacological approach to Sap (show APCS Antibodies) C deficiency directed to treat major secondary pathological aspects in this disorder.
PSAP is a secreted biomarker.
findings support a lung metastasis-promoting function of the miR (show MLXIP Antibodies)-23b/27b/24 cluster of miRNAs, which functions in part through the direct inhibition of PSAP in breast cancer
Of the 2575 proteins identified, proteins upregulated in gallbladder cancer included several lysosomal proteins such as prosaposin, cathepsin Z (show CTSZ Antibodies) and cathepsin H (show CTSH Antibodies).
Saposin C protects glucocerebrosidase (show GBA Antibodies) against alpha-synuclein (show SNCA Antibodies) inhibition.
Urine of patients with early prostate cancer contains lower levels of light chain fragments of inter-alpha-trypsin inhibitor and prosaposin fragment or saposin B.
identified 68 single-nucleotide polymorphisms and 9 indels in the pig PASP (show CPB1 Antibodies) gene, and three single-nucleotide polymorphisms were nonsynonymous substitutions
Saposin B (Sap (show APCS Antibodies) B) is not a limiting factor of the coupled Sap (show APCS Antibodies) B-arylsulfatase A (show ARSA Antibodies) reaction in mouse kidney cells even if sulfatide has accumulated to unphysiologically high levels.
This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.
prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)
, proactivator polypeptide-like
, mitochondrial carrier homolog 1
, mitochondrial carrier-like protein 1
, proactivator polypeptide
, sphingolipid activator protein-1
, snoRNA MBII-198
, sulfated glycoprotein 1
, prosaposin (sulfated glycoprotein, sphingolipid hydrolase activator)
, Surfactant-associated protein 1 (pulmonary surfactant protein SP-A)
, Surfactant-associated protein 1 (pulmonary surfactant protein, SP-A)
, pulmonary surfactant-associated protein A
, surfactant associated protein A
, surfactant, pulmonary-associated protein A1