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Prosaposin Proteins (PSAP)

PSAP encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Additionally we are shipping Prosaposin Antibodies (101) and Prosaposin Kits (37) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PSAP 56462 Q791T5
PSAP 5660 P07602
PSAP 25524 P10960
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Top Prosaposin Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,123.00
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,123.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,536.50
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Human Cells Rat His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details
HOST_Human Cells Human His tag   100 μg Log in to see 16 Days
$437.80
Details

PSAP Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , ,
,
Rat (Rattus) ,

Top referenced Prosaposin Proteins

  1. Human Prosaposin Protein expressed in Wheat germ - ABIN1316504 : Wu, Sun, Zou, Xu, Liu, Wang, Yun, Gu: Prosaposin, a regulator of estrogen receptor alpha, promotes breast cancer growth. in Cancer science 2012 (PubMed)
    Show all 2 references for ABIN1316504

More Proteins for Prosaposin (PSAP) Interaction Partners

Zebrafish Prosaposin (PSAP) interaction partners

Mouse (Murine) Prosaposin (PSAP) interaction partners

  1. Data suggested that the abundance of Psap in sperm sample may be a sensitive endpoint to predict PCB exposure.

  2. Prosaposin facilitates sortilin (show SORT1 Proteins)-independent lysosomal trafficking of progranulin (show GRN Proteins).

  3. Mesotrypsin (show PRSS3 Proteins) generated saposins A-D from prosaposin, and mature caspase-14 (show CASP14 Proteins) contributed to this process by activating mesotrypsinogen (show PRSS3 Proteins) to mesotrypsin (show PRSS3 Proteins). Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.

  4. Low levels of prosaposin and its receptors in the mouse brain suggest the participation of prosaponin in pathological changes in the brains of dystrophic mdx (show DMD Proteins) mice.

  5. These data show functional association between GPR37, prosaposin, and GM1 ganglioside in the plasma membrane.

  6. Prosaposin is involved in the regulation of muscle differentiation of regenerated fibres

  7. Saposins A and B deficiencies attenuated GalCer-beta-galactosylceramidase (show GALC Proteins) and GM1-beta-galactosidase (show GLB1 Proteins) functions in the degradation of lactosylceramide in the liver.

  8. These data suggest that prosaposin plays an important role in the neuronal maturation processes of the vestibular sensory epithelium and the maintenance of normal vestibular system function.

  9. The saposin C deficient mice backcrossed to point mutated GCase (show GBA Proteins) mimics the central nervous system phenotype and biochemistry of some type 3 (neuronopathic) variants of Gaucher disease.

  10. UGT1 aids in the folding of sequential domain-containing proteins such as prosaposin.

Human Prosaposin (PSAP) interaction partners

  1. Our findings suggest a novel pharmacological approach to Sap (show APCS Proteins) C deficiency directed to treat major secondary pathological aspects in this disorder.

  2. PSAP is a secreted biomarker.

  3. Data suggested that the abundance of Psap in sperm sample may be a sensitive endpoint to predict PCB exposure.

  4. Prosaposin facilitates sortilin (show SORT1 Proteins)-independent lysosomal trafficking of progranulin (show GRN Proteins).

  5. findings support a lung metastasis-promoting function of the miR (show MLXIP Proteins)-23b/27b/24 cluster of miRNAs, which functions in part through the direct inhibition of PSAP in breast cancer

  6. Mesotrypsin (show PRSS3 Proteins) generated saposins A-D from prosaposin, and mature caspase-14 (show CASP14 Proteins) contributed to this process by activating mesotrypsinogen (show PRSS3 Proteins) to mesotrypsin (show PRSS3 Proteins). Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.

  7. Of the 2575 proteins identified, proteins upregulated in gallbladder cancer included several lysosomal proteins such as prosaposin, cathepsin Z (show CTSZ Proteins) and cathepsin H (show CTSH Proteins).

  8. Saposin C protects glucocerebrosidase against alpha-synuclein inhibition.

  9. Urine of patients with early prostate cancer contains lower levels of light chain fragments of inter-alpha-trypsin inhibitor and prosaposin fragment or saposin B.

  10. These findings suggested that prosaposin might enhance estrogen receptor alpha (show ESR1 Proteins)-mediated signaling axis and play a role in breast cancer development and progression.

Pig (Porcine) Prosaposin (PSAP) interaction partners

  1. identified 68 single-nucleotide polymorphisms and 9 indels in the pig PASP (show CPB1 Proteins) gene, and three single-nucleotide polymorphisms were nonsynonymous substitutions

  2. Saposin B (Sap (show APCS Proteins) B) is not a limiting factor of the coupled Sap (show APCS Proteins) B-arylsulfatase A (show ARSA Proteins) reaction in mouse kidney cells even if sulfatide has accumulated to unphysiologically high levels.

Prosaposin (PSAP) Protein Profile

Protein Summary

This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with Prosaposin Proteins (PSAP)

  • prosaposin (psap)
  • prosaposin (PSAP)
  • prosaposin (LOC100304726)
  • prosaposin (LOC100526719)
  • mitochondrial carrier homolog 1 (C. elegans) (Mtch1)
  • prosaposin (Psap)
  • prosaposin (LOC100359322)
  • surfactant protein A1 (Sftpa1)
  • 2310034O17Rik protein
  • AI037048 protein
  • AI255158 protein
  • AU018396 protein
  • C77849 protein
  • cb759 protein
  • GLBA protein
  • PSAP protein
  • SAP1 protein
  • Sftp1 protein
  • Sftpa protein
  • Sftpl protein
  • SGP-1 protein
  • SGP1A protein
  • SP-A protein
  • wu:fa14a06 protein
  • wu:fb36e02 protein
  • wu:fb58g07 protein

Protein level used designations for Prosaposin Proteins (PSAP)

prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) , prosaposin , proactivator polypeptide-like , mitochondrial carrier homolog 1 , mitochondrial carrier-like protein 1 , proactivator polypeptide , sphingolipid activator protein-1 , snoRNA MBII-198 , sulfated glycoprotein 1 , prosaposin (sulfated glycoprotein, sphingolipid hydrolase activator) , PSAP , PSP-A , Surfactant-associated protein 1 (pulmonary surfactant protein SP-A) , Surfactant-associated protein 1 (pulmonary surfactant protein, SP-A) , pulmonary surfactant-associated protein A , surfactant associated protein A , surfactant, pulmonary-associated protein A1

GENE ID SPECIES
140811 Danio rerio
450517 Pan troglodytes
709510 Macaca mulatta
100011417 Monodelphis domestica
100304726 Ictalurus punctatus
100399482 Callithrix jacchus
100526719 Ictalurus punctatus
100593695 Nomascus leucogenys
56462 Mus musculus
5660 Homo sapiens
19156 Mus musculus
25524 Rattus norvegicus
100359322 Oryctolagus cuniculus
100713024 Cavia porcellus
100153167 Sus scrofa
281433 Bos taurus
395602 Gallus gallus
479240 Canis lupus familiaris
100135695 Ovis aries
24773 Rattus norvegicus
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