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Prostacyclin Receptor Proteins (PTGIR)

The protein encoded by PTGIR is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Additionally we are shipping Prostacyclin Receptor Antibodies (64) and Prostacyclin Receptor Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTGIR 19222 P43252
PTGIR 5739 P43119
Rat PTGIR PTGIR 292661 P43253
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Top Prostacyclin Receptor Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$246.96
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days
$491.43
Details

PTGIR Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Prostacyclin Receptor (PTGIR) Interaction Partners

Mouse (Murine) Prostacyclin Receptor (PTGIR) interaction partners

  1. Prostacyclin promotes the up-regulation of Nox4 (show NOX4 Proteins) in endothelial cells, which opens up a novel strategy that protects and enhances endothelial cell functions in cardiovascular disease, such as repair after myocardial infarction or other ischemic conditions.

  2. Its signaling increase cAMP concentration, which prototes sysnesis of HGF (show HGF Proteins), causing angiogenesis.

  3. an essential role of the COX-2/PGI2 receptor axis in the cardioprotection afforded by the late ischemic preconditioning

  4. findings suggest the IP receptor might maintain an angiogenic switch in the "on" state in tumor endothelial cells (TEC); suggest that the IP receptor is a TEC-specific marker and might be a useful therapeutic target

  5. PGI2-induced PPAR delta (show PPARD Proteins) activation accelerates blastocyst hatching in mice

  6. For the first time these results show that activation of prostaglandin I2 receptor can attenuate damage following cerebral ischemia.

  7. identify PGI(2)-prostaglandin I2 receptor as an important pathway for inhibiting allergic pulmonary inflammation by controlling recruitment of CD4 (show CD4 Proteins)(+) Th2 cells into the inflammatory site

  8. The prostacyclin/IP pathway suppresses cardiac fibrosis, at least partly, by inducing CREB (show CREB1 Proteins) phosphorylation.

  9. Prostaglandin I2 receptor signaling promotes T helper cell type (Th)1 (show TH1L Proteins) differentiation through a cyclic adenosine monophosphate (AMP (show TMPRSS5 Proteins))-protein kinase A pathway, thereby initiating acquired cutaneous immune responses.

  10. critical differences in signaling by the mIP and hIP that are regulated by their differential phosphorylation by PKA and PKC

Human Prostacyclin Receptor (PTGIR) interaction partners

  1. these findings suggest that reduced IPR expression in DM2 (show CNBP Proteins) platelets may contribute to platelet hyperactivity in humans with type 2 diabetes.

  2. Prostaglandin I2- Prostaglandin I2 receptor signaling regulates human Th17 and Treg cell differentiation.

  3. these data provide critical insights into the transcriptional regulation of the human prostacyclin receptor gene within the vasculature, including during megakaryocytic differentiation

  4. IP receptor heteridimerization with thromboxane receptor facilitates receptor trafficking to membrane lipid rafts.

  5. Prostacyclin receptor-dependent inhibition of human erythroleukemia cell differentiation is STAT3 (show STAT3 Proteins)-dependent

  6. IKEPP (show PDZD3 Proteins) was also found to be expressed in vascular endothelial cells where it co-localizes and complexes with the hIP

  7. the IP receptor was expressed in blood vessels of renal cell carcinoma specimens, but not in glomerular vessels of normal renal tissue; findings suggest the IP receptor might maintain an angiogenic switch in the "on" state in tumor endothelial cells (TEC); suggest that the IP receptor is a TEC-specific marker and might be a useful therapeutic target

  8. VDAC is the ATP conduit in the IP receptor-mediated signaling pathway in human erythrocytes.

  9. Human prostacyclin receptor interacts with the PDZ adapter protein (show TOLLIP Proteins) PDZK1 (show PDZK1 Proteins); this interaction plays important role in endothelial cell migration and angiogenesis.

  10. IP(R212C) exerts a dominant action on the wild-type IP and thromboxane receptor through dimerization. This likely contributes to accelerated cardiovascular disease in individuals carrying 1 copy of the variant allele.

Prostacyclin Receptor (PTGIR) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor.

Gene names and symbols associated with Prostacyclin Receptor Proteins (PTGIR)

  • prostaglandin I receptor (IP) (Ptgir)
  • prostaglandin I2 (prostacyclin) receptor (IP) (PTGIR)
  • prostaglandin I2 (prostacyclin) receptor (IP) (Ptgir)
  • IP protein
  • PGI2 protein
  • PRIPR protein

Protein level used designations for Prostacyclin Receptor Proteins (PTGIR)

PGI receptor , PGI2 receptor , prostacyclin receptor , prostaglandin I2 receptor , prostanoid IP receptor , prostaglandin I receptor (IP)

GENE ID SPECIES
19222 Mus musculus
5739 Homo sapiens
292661 Rattus norvegicus
520278 Bos taurus
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