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Prostaglandin D2 Synthase 21kDa (Brain) Proteins (PTGDS)

The protein encoded by PTGDS is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). Additionally we are shipping PTGDS Antibodies (75) and PTGDS Kits (74) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTGDS 19215 O09114
PTGDS 25526 P22057
PTGDS 5730 P41222
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Top PTGDS Proteins at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$756.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,370.50
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,377.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,377.83
Details

PTGDS Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , , , ,
, , ,

Top referenced PTGDS Proteins

  1. Human PTGDS Protein expressed in Escherichia coli (E. coli) - ABIN667417 : Giacomelli, Leone, Grima, Silvestrini, Cheng: Astrocytes synthesize and secrete prostaglandin D synthetase in vitro. in Biochimica et biophysica acta 1996 (PubMed)
    Show all 2 references for ABIN667417

  2. Human PTGDS Protein expressed in Human Cells - ABIN2005657 : Humphray, Oliver, Hunt, Plumb, Loveland, Howe, Andrews, Searle, Hunt, Scott, Jones, Ainscough, Almeida, Ambrose, Ashwell, Babbage, Babbage, Bagguley, Bailey, Banerjee, Barker, Barlow, Bates, Beasley et al.: DNA sequence and analysis of human chromosome 9. ... in Nature 2004 (PubMed)
    Show all 2 references for ABIN2005657

More Proteins for Prostaglandin D2 Synthase 21kDa (Brain) (PTGDS) Interaction Partners

Mouse (Murine) Prostaglandin D2 Synthase 21kDa (Brain) (PTGDS) interaction partners

  1. Ptgds is targeted and repressed by the CUL4B (show CUL4B Proteins)/PRC2 complex.

  2. Thermodynamic and nuclear magnetic resonance analyses demonstrated that L-PGDS binds to nicotinamide coenzymes, including NADPH, NADP(+), and NADH.

  3. Prostaglandin D2 synthase is a novel MR target gene in adipocytes.

  4. When prostaglandin D2 synthase is upregulated it participates in the regulation of peripheral nervous system myelination.

  5. expression of L-PGDS in mouse lungs decreased neutrophilic infiltration, ameliorating lung inflammation in mice.

  6. Silencing of PTGDS also alleviated H-rev107 (show HRASLS Proteins)-mediated suppression of cell migration and invasion

  7. In this report, we show for the first time that alteration of the PTGDS-governed PGD2 pathway disturbs testicular migration in mice.

  8. Data indicate a PLA2G3 (show PLA2G3 Proteins)-lipocalin (show APOD Proteins)-type PGD2 synthase (L-PGDS)-PGD2 receptor DP1 (show PTGDR Proteins) loop that drives mast cell maturation.

  9. The levels of lipocalin (show APOD Proteins)-type prostaglandin D2 synthase, and its product PGD2 each varied significantly among background strains of mice after wounding, and the highest Ptgds and PGD2 levels were associated with the lowest amount of regeneration.

  10. L-PGDS and PPARgamma2 (show PPARG Proteins) coordinate to regulate carbohydrate and lipid metabolism.

Human Prostaglandin D2 Synthase 21kDa (Brain) (PTGDS) interaction partners

  1. BTP and B2M (show B2M Proteins) levels are less affected than serum by amputation, and should be considered for future study of GFR (show RAPGEF5 Proteins) estimation

  2. Hematopoietic prostaglandin D synthase (show HPGDS Proteins) defines a proeosinophilic pathogenic effector human T(H)2 cell subpopulation with enhanced function

  3. levels of L-PGDS in cervicovaginal secretions of pregnant women at different stages of parturition correlate with preterm birth.

  4. PTGDS mRNA expression was down-regulated in rapid-cycling bipolar disorder patients in a euthymic, depressive, and manic/hypomanic state compared with healthy control subjects.

  5. Expression of MR and prostaglandin D2 synthase is strongly correlated in adipose tissues from obese patients.

  6. These data indicate that scalp is spatially programmed via mast cell prostaglandin D-synthase distribution in a manner reminiscent of the pattern seen in androgenetic alopecia.

  7. These results suggest that L-PGDS acted as a scavenger of biliverdin, which is a molecule not found in normal CSF (show CSF2 Proteins).

  8. Lipocalin (show APOD Proteins)-type prostaglandin D2 (PGD2) synthase (L-PGDS) interacts intracellularly with the G protein-coupled receptor (show ADRA1A Proteins) DP1 (show PTGDR Proteins) in an agonist-independent manner.

  9. Among NSTE-ACS (show PLA2G15 Proteins) patients, BTP and CysC (show CST3 Proteins) were superior to conventional renal parameters for predicting MB, and improved clinical stratification for hemorrhagic risk.

  10. Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase.

Cow (Bovine) Prostaglandin D2 Synthase 21kDa (Brain) (PTGDS) interaction partners

  1. L-PGDS may have a role in cattle fertilization.

PTGDS Protein Profile

Protein Summary

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.

Gene names and symbols associated with PTGDS

  • hematopoietic prostaglandin D synthase (HPGDS)
  • prostaglandin D2 synthase 21kDa (brain) (PTGDS)
  • lipocalin 15 (lcn15)
  • prostaglandin D2 synthase, hematopoietic (LOC100353701)
  • prostaglandin D2 synthase 21kDa (brain) (ptgds-b)
  • prostaglandin D synthase (LOC100009453)
  • prostaglandin D2 synthase (brain) (Ptgds)
  • 21kDa protein
  • cerebrin-28 protein
  • cpl-1 protein
  • L-PGDS protein
  • LPGDS protein
  • PDS protein
  • PGD2 protein
  • pgds protein
  • PGDS2 protein
  • PH2DISO protein
  • PTGDS protein
  • Ptgs3 protein
  • XlCpl1 protein
  • zgc:153919 protein

Protein level used designations for PTGDS

prostaglandin D2 synthase, hematopoietic , prostaglandin D2 synthase 21kDa (brain) , prostaglandin-H2 D-isomerase , Prostaglandin D Synthase , lipocalin , prostaglandin D2 synthase, brain , GST class-sigma , H-PGDS , glutathione S-transferase , glutathione-dependent PGD synthase , glutathione-dependent PGD synthetase , glutathione-requiring prostaglandin D synthase , prostaglandin-D synthase , PGD2 synthase , glutathione-independent PGD synthase , glutathione-independent PGD synthetase , lipocalin-type prostaglandin-D synthase , prostaglandin D2 synthase (21 kDa, brain) , prostaglandin-D2 synthase , PGDS , PGDS2 , Prostaglandin D synthase , beta-trace protein , cerebrin-28 , lipocalin-type prostaglandin D synthase , prostaglandin D synthase

GENE ID SPECIES
705227 Macaca mulatta
749402 Pan troglodytes
751703 Danio rerio
100353701 Oryctolagus cuniculus
397884 Xenopus laevis
395863 Gallus gallus
100009453 Oryctolagus cuniculus
19215 Mus musculus
25526 Rattus norvegicus
5730 Homo sapiens
493852 Felis catus
100067921 Equus caballus
397456 Sus scrofa
286858 Bos taurus
403740 Canis lupus familiaris
443192 Ovis aries
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