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The protein encoded by PTGER1 is a member of the G protein-coupled receptor family. Additionally we are shipping Prostaglandin E Receptor 1 (Subtype EP1), 42kDa Antibodies (63) and Prostaglandin E Receptor 1 (Subtype EP1), 42kDa Proteins (4) and many more products for this protein.
PGE2 serves as a central regulator of the Ren (show REN1 ELISA Kits)-1c gene in the principal cells of the kidney collecting ducts via the PKC (show PKC ELISA Kits)/cAMP/CREB (show CREB1 ELISA Kits) pathway.
Our study identifies the EP1 signaling pathway as an important link between neuroinflammation and MMP-mediated BBB (show ALMS1 ELISA Kits) breakdown in ischemic stroke.
EP1-/- mice maintain increased bone mineral density and stronger cortical and trabecular bone biomechanical properties with aging. The EP1 receptor acts to inhibit bone marrow osteoprogenitor cell differentiation and mineralization.
Results indicate that EP1 receptor activation during seizures, through a protein kinase C (show PKC ELISA Kits) pathway, increases probability of kainic acid induced status epilepticus, and independently promotes hippocampal neurodegeneration and a broad inflammatory response
The EP1 receptor facilitates the actions of angiotensin II, thereby suggesting that targeting of both the renin (show REN ELISA Kits)-angiotensin system and the EP1 receptor could be beneficial in diabetic nephropathy.
Propose a mechanism whereby ANG II (show AGT ELISA Kits) increases COX-1 (show PTGS1 ELISA Kits)-derived PGE2 through the AT1R (show AGTRAP ELISA Kits)/PLA2 (show PLA2G2A ELISA Kits) pathway, which promotes ROS (show ROS1 ELISA Kits) production by EP1R/Nox2 (show CYBB ELISA Kits) signaling in the subfornical organ.
dietary administration and direct injection of the EP1 receptor-specific antagonist, ONO-8713, effectively reduced the growth of established CT26 tumors in BALB/c mice
EP1 deletion protects mice from asymmetrical Parkinsonism. The PGE2 EP1 receptor is implicated in 6-OHDA-induced Parkinsonism.
Data suggest that EP1 receptor blockade may be a viable target for antihypertensive therapy.
data suggest that the tumor promoting/progressing effects of EP1 require the PGE2 synthesized by COX-2 (show COX2 ELISA Kits)
COX-2 (show COX2 ELISA Kits) expression appears to be linked to early hepatocellular carcinoma events (initiation), while EP1 receptor expression may participate in tumor progression and predict survival
Copy number variation in PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema
suppression of EP1 prevented RAMA-induced FasL (show FASL ELISA Kits) suppression in CLT85 cells at both the mRNA and protein levels
A transient interaction between COX-2 (show COX2 ELISA Kits) and EP1 constitutes a feedback loop whereby an increase in COX-2 (show COX2 ELISA Kits) expression elevates EP1.
NF-kappaB (show NFKB1 ELISA Kits) inhibitor suppressed 17-PT-PGE2-mediated FoxC2 (show FOXC2 ELISA Kits) upregulation. Immunohistochemistry showed p65 (show GORASP1 ELISA Kits), FoxC2 (show FOXC2 ELISA Kits), EP1 receptor and beta1-integrin were all highly expressed in the HCC (show FAM126A ELISA Kits) cases
COX-1 (show COX1 ELISA Kits), H446K' is significantly more sensitive to downregulation by EP . Together these data suggest that distinctive ubiquitination of COX-1 (show COX1 ELISA Kits) and COX-2 (show COX2 ELISA Kits) may be responsible for their different sensitivity to EP -mediated degradation.
through complex formation with D1, EP1 signaling directs the D1 receptor through G(betagamma) to be coupled to AC7 (show Adcy7 ELISA Kits).
PGE2-enhanced MMP2 (show MMP2 ELISA Kits) expression is mediated through EP1 receptors and calcium signaling pathway-induced CREB (show CREB1 ELISA Kits) phosphorylation in human cholangiocarcinoma cells.
Our study suggests that the PGE (show LIPF ELISA Kits) EP1 receptor regulates FAK (show PTK2 ELISA Kits) phosphorylation by activating the PKC/c-Src (show SRC ELISA Kits) and EGFR (show EGFR ELISA Kits) signal pathways, which may coordinately regulate adhesion and migration in HCC (show FAM126A ELISA Kits)
PGE (show LIPF ELISA Kits)(2) -mediated NF-kappaB (show NFKB1 ELISA Kits) activation by simultaneous stimulation of EP(1) and EP(4 (show PTGER4 ELISA Kits)) receptors induces maximal IL-8 (show IL8 ELISA Kits) promoter activation and IL-8 (show IL8 ELISA Kits) mRNA and protein induction
The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.
prostaglandin E receptor 1 (subtype EP1), 42kDa
, prostaglandin E2 receptor subtype EP1
, PGE receptor EP1 subtype
, PGE2 receptor EP1 subtype
, prostaglandin E2 receptor EP1 subtype
, prostanoid EP1 receptor
, EP1 prostanoid receptor
, PGE receptor, EP1 subtype
, prostaglandin E receptor EP1 subtype
, prostaglandin E receptor 1, subtype EP1