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Prostaglandin E Synthase Proteins (PTGES)

The protein encoded by PTGES is a glutathione-dependent prostaglandin E synthase. Additionally we are shipping Prostaglandin E Synthase Antibodies (53) and Prostaglandin E Synthase Kits (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTGES 9536 O14684
PTGES 64292 Q9JM51
Rat PTGES PTGES 59103  
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Top Prostaglandin E Synthase Proteins at

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

PTGES Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for Prostaglandin E Synthase (PTGES) Interaction Partners

Human Prostaglandin E Synthase (PTGES) interaction partners

  1. Data show that cyclooxygenase2 (COX2)overexpression induces prostaglandin E synthase (PTGES) through early growth response 1 (EGR1 (show EGR1 Proteins)) in colorectal cancer cell lines.

  2. mPGES-1 is downregulated via EGR1 (show EGR1 Proteins) and has a role in caffeine inhibition on PGE2 synthesis of HBx hepatocytes

  3. results demonstrate that mPGES-1 is a target gene of defective mismatch repair in human colorectal cancer, with functional consequence

  4. Altered expression of EP2 (show SPAG11B Proteins) in patients with aspirin-exacerbated respiratory disease contributes to deficient induction of IL-1RI, reducing the capacity of IL-1beta (show IL1B Proteins) to increase COX-2 and mPGES-1 expression, which results in low PGE2 production

  5. High levels of intra tumoral mPGES-1 is associated with poor prognosis. mPGES-1 after chemotherapy is associated with improved outcomes.

  6. mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor (show EGFR Proteins)-driven oncogenicity

  7. we investigated the changes in promoter methylation patterns using methylation arrays and observed that the promoters of immunomodulatory factors, COX2 and PTGES, and migration-related factors, CXCR2 (show CXCR2 Proteins) and CXCR4 (show CXCR4 Proteins), were hypomethylated after 5-aza treatment

  8. Data suggest that, in organization of enzymes in post-translational endoplasmic reticulum, mPGES1 is likely co-localized with COX2 (cyclooxygenase-2 (show PTGS2 Proteins)) within a distance of 14.4 A; mPGES-1 is localized much farther from COX1 (cyclooxygenase-1 (show PTGS1 Proteins)).

  9. mPGES-1 expression is positively correlated to hepatitis B virus X protein expression in hepatocellular carcinoma tissue.

  10. Data indicate that inhibition of lysine-specific demethylase 1 activity prevented IL-1beta (show IL1B Proteins)-induced histone H3 (show HIST3H3 Proteins) lysine 9 (H3K9) demethylation at microsomal prostaglandin E synthase 1 (mPGES-1) promoter.

Mouse (Murine) Prostaglandin E Synthase (PTGES) interaction partners

  1. Prostacyclin synthase (show PTGIS Proteins) and prostaglandin E synthase-1 cooperatively exacerbate inflammatory reactions but have opposing effects on carcinogenesis.

  2. Gas6 (show GAS6 Proteins), through upregulation of Ptges/PGE2, contributes to cancer-induced venous thrombosis.

  3. Vascular mPGES-1 plays a protective role in blood vessels and attenuates rupture of cerebral aneurysms.

  4. Suggest pivotal role of COX-2-mPGES-1-PGE2 axis in vascular calcification. Inhibition of COX-2 or mPGES-1 may increase the risk of calcification and subsequent adverse cardiovascular events during chronic renal failure.

  5. The present results suggest that mPGES-1 plays a significant role in lymphangiogenesis during inflammation, and represents a novel target for controlling IL.

  6. data suggests that an as yet unidentified prostaglanind E synthase but not mPGES-1 may couple with COX-2 to mediate increased renal PGE2 sythsesis in DN.

  7. This study shown that mPGES-1 is expressed in the mouse brain, both in vascular endothelial cells, in several other cellular of capillary associated pericytes, astrocytes, and cells in circumventricular organs, choroid plexus, and leptomeninges.

  8. mPGES-1 deficiency exacerbates bleomycin-induced pulmonary fibrosis.

  9. mPGES-1 appears to be critical for tumor metastasis in prostate cancers

  10. Melatonin modulates microsomal PGE (show LIPF Proteins) synthase 1 and NF-E2-related factor-2 (show NFE2L2 Proteins)-regulated antioxidant enzyme expression in LPS (show TLR4 Proteins)-induced murine peritoneal macrophages.

Cow (Bovine) Prostaglandin E Synthase (PTGES) interaction partners

  1. Prostaglandin E synthase interacts with inducible heat shock protein 70 (show HSPA1A Proteins) after heat stress in bovine primary dermal fibroblast cells.

  2. Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF (show TNF Proteins)) and Fas (show FAS Proteins) were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.

  3. Data suggest that elevated temperatures stimulate PGE2 production in ampullary oviduct by increasing expression of PGES and HSP90AA1 (show HSP90AA1 Proteins) (heat shock 90 kD protein 1 alpha).

  4. PGES pathway is responsible for the endometrial production of PGE (show LIPF Proteins)(2) in the bovine endometrium during the estrous cycle

Horse (Equine) Prostaglandin E Synthase (PTGES) interaction partners

  1. This study showed that COX-1 (show PTGS1 Proteins) and COX-2 (show PTGS2 Proteins) in genital carcinomas in the horse is poor; microsomal PGES-1 is more prominently expressed.

Prostaglandin E Synthase (PTGES) Protein Profile

Protein Summary

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.

Gene names and symbols associated with PTGES

  • prostaglandin E synthase (PTGES)
  • prostaglandin E synthase (ptges)
  • prostaglandin E synthase (Ptges)
  • 2410099E23Rik protein
  • D2Ertd369e protein
  • MGC80290 protein
  • MGST-IV protein
  • MGST1-L1 protein
  • MGST1L1 protein
  • mPGES protein
  • MPGES-1 protein
  • Pges protein
  • PIG12 protein
  • PP102 protein
  • PP1294 protein
  • PTGES protein
  • TP53I12 protein

Protein level used designations for PTGES

microsomal prostaglandin E synthase-1 , prostaglandin E synthase , MGST1-like 1 , glutathione S-transferase 1-like 1 , microsomal glutathione S-transferase 1-like 1 , microsomal prostaglandin E synthase 1 , p53-induced apoptosis protein 12 , p53-induced gene 12 protein , tumor protein p53 inducible protein 12

417193 Gallus gallus
654407 Sus scrofa
446534 Xenopus laevis
473071 Pan troglodytes
9536 Homo sapiens
64292 Mus musculus
59103 Rattus norvegicus
100733230 Cavia porcellus
282019 Bos taurus
480698 Canis lupus familiaris
100034143 Equus caballus
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