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PTGIS encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping Prostaglandin I2 (Prostacyclin) Synthase Antibodies (63) and Prostaglandin I2 (Prostacyclin) Synthase Proteins (8) and many more products for this protein.
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Prostacyclin synthase and prostaglandin E synthase (show PTGES ELISA Kits)-1 cooperatively exacerbate inflammatory reactions but have opposing effects on carcinogenesis.
Cyclooxygenase-2 (show PTGS2 ELISA Kits)-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor (show F3 ELISA Kits) in a sirtuin-1 (show SIRT1 ELISA Kits)-dependent-manner.
CD40 ligand (show CD40LG ELISA Kits) might contribute to the initiation and progression of atherosclerosis by increasing activity of prostacyclin synthase.
Sepiapterin not only reversed the effects of high glucose on both angiotensin II-induced relaxation and PGI(2 (show PTGIR ELISA Kits)) release but also abolished high-glucose-enhanced PGIS nitration.
Alpha(2)-adrenoreceptor activation is required for coupling heart rate to central inspiratory drive during acute hypoxia, and PGI(2 (show PTGIR ELISA Kits)) is required to enhance the inhibition of sympathoactivation.
The results provide strong evidence that the protective effects of COX-2 (show COX2 ELISA Kits) within the liver are mediated through the production of PGE (show LIPF ELISA Kits)(2) and PGI(2 (show PTGIR ELISA Kits)), which exert anti-inflammatory functions.
Endothelial PGI (show BGN ELISA Kits) synthase-mediated prostacyclin contributes to renal protection against endotoxemia-related acute kidney injury.
identify PGI(2)-prostaglandin I2 receptor (show PTGIR ELISA Kits) as an important pathway for inhibiting allergic pulmonary inflammation by controlling recruitment of CD4 (show CD4 ELISA Kits)(+) Th2 cells into the inflammatory site
COX-1 (show PTGS1 ELISA Kits) contributes to the enhanced formation of both PGI(2 (show PTGIR ELISA Kits)) and TXA(2 (show TBXA2R ELISA Kits)) in atherosclerosis, and to the development of the disease
PGIS/ IP transgenic animals with lung-specific PPARgamma (show PPARG ELISA Kits) overexpression also developed fewer lung tumors.
In examining the tumor suppressor PTGIS as a potential biomarker for treatment with either 5-Aza-dC or TSA (show PRDX2 ELISA Kits), 5-Aza-dC effectively stabilized cell cycling, restricted genetic instability and derepressed PTGIS expression
Based on the predicted crystal structure of CYP8A1( *)5 using the Molecular Operating Environment platform, the distance from CYP8A1 Cys441 to the heme was altered with a significantly changed binding free energy for the mutant protein.
results indicate that PGIS expression was associated with radiotherapy efficiency
Type-2 diabetes is associated with higher COX-2 (show COX2 ELISA Kits) expression, but lower eNOS (show NOS3 ELISA Kits) and PGIS expression in subcutaneous arteries.
In a case-control study unaffected carriers of a BMPR2 mutation, linked to pulmonary artery hypertension (PAH), were most often found to have prostacyclin synthase promoter sequence variants, which were thought to protect against PAH.
These findings suggest that PGIS is induced by hypoxia and regulates the expression of VEGF in fibroblasts.
High PTGIS expression is associated with colorectal cancer hepatic metastasis.
The CC genotype of C1117A polymorphism is associated with higher risk of LM-CAD (show CAD ELISA Kits)
Overexpression of PTGIS is associated with liver metastasis in colon cancer.
diabetes preferentially increases PGIS nitration that is associated with excessive vascular inflammation in atherosclerotic carotid arteries from patients with type 2 diabetes
crystal structures of ligand-free, inhibitor (minoxidil)-bound and substrate analog U51605-bound PGIS
Disturbances in prostacyclin synthase and its receptor may lead to disruption of the oviductal environment and, in turn, perturbed development of embryos and their transport to the uterus.
Prostacyclin synthase is differentially expressed in the endometrium of cyclic and pregnant gilts resulting in higher PGI(2 (show PTGIR ELISA Kits)) synthesis in pregnant animals
CRP (show CRP ELISA Kits) stimulates superoxide production and the subsequent formation of peroxynitrite from basal released nitric oxide compromises PGI(2 (show PTGIR ELISA Kits)) synthesis.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.
, prostaglandin I2 (prostacyclin) synthase
, prostaglandin I2 synthase
, cytochrome P450, family 8, subfamily A, polypeptide 1
, prostaglandin I2 (prostacyclin) synthase like
, cytochrome P450 8A1