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This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. Additionally we are shipping PTGS1 Kits (62) and PTGS1 Proteins (10) and many more products for this protein.
Showing 10 out of 127 products:
Human Polyclonal PTGS1 Primary Antibody for IF, IHC (p) - ABIN1882120
Helmersson, Arnlöv, Axelsson, Basu: A polymorphism in the cyclooxygenase 1 gene is associated with decreased inflammatory prostaglandin F2alpha formation and lower risk of cardiovascular disease. in Prostaglandins, leukotrienes, and essential fatty acids 2009
Human Polyclonal PTGS1 Primary Antibody for EIA, IHC (p) - ABIN782890
Yokoyama, Tanabe: Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. in Biochemical and biophysical research communications 1990
Cow (Bovine) Polyclonal PTGS1 Primary Antibody for WB - ABIN2777019
Canzian, Franceschi, Plummer, van Doorn, Lu, Gioia-Patricola, Vivas, Lopez, Severson, Schwartz, Muñoz, Kato: Genetic polymorphisms in mediators of inflammation and gastric precancerous lesions. in European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2008
Cow (Bovine) Polyclonal PTGS1 Primary Antibody for IHC, WB - ABIN2777018
Chubb, Fitzgerald, Nolan, Moman: The productive conformation of prostaglandin G2 at the peroxidase site of prostaglandin endoperoxide H synthase: docking, molecular dynamics, and site-directed mutagenesis studies. in Biochemistry 2006
This study showed that COX-1 and COX-2 (show PTGS2 Antibodies) in genital carcinomas in the horse is poor; microsomal PGES (show PTGES Antibodies)-1 is more prominently expressed.
COX-1 and COX-2 (show PTGS2 Antibodies) genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 (show PTGS2 Antibodies) gene expression at each subsequent time point, compared with baseline values.
In this study, both COX-1 and COX-2 (show PTGS2 Antibodies) were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2 (show PTGS2 Antibodies).
Immunoreactivity for COX-1 and COX-2 (show PTGS2 Antibodies) is high in equine corneal SCC (show CYP11A1 Antibodies), possibly indicating that COX (show CPOX Antibodies) plays a role in oncogenesis or progression of this tumor type at this site.
Suggest the expression of COX-1 and COX-2 (show COX2 Antibodies) in the urothelium protects bladder damage from radiation.
COX-1 inhibitor SC-560 has a protective effect on the thromboxane A2-mediated decrease in renal function in response to endotoxin.
Expression of COX-1 is essential for the protection of liver against chemical-induced hepatotoxicity and required for hepatic homeostatic maintenance.
Data suggest that multitarget FAAH (show FAAH Antibodies)/Cox (show CPOX Antibodies) blockade may provide a transformative approach to inflammatory bowel disease (IBD) and other pathologies in which fatty acid amide hydrolase (show FAAH Antibodies)/cyclooxygenases (FAAH (show FAAH Antibodies), Cox-1, and Cox-2 (show COX2 Antibodies)) are overactive.
In arteries from non-insulin (show INS Antibodies)-dependent diabetic mice, COX-1 remains a major contributor to the endothelial PGI2 (show PTGIR Antibodies) synthesis that evokes vasoconstrictor activity under the pathological condition.
specific inhibition of mmu-miR (show MLXIP Antibodies)-100-5p significantly enhanced expression of Il6 (show IL6 Antibodies), Ptgs1/2 and Tlr4 (show TLR4 Antibodies) mRNA
COX1 (show COX1 Antibodies)/2-derived prostanoids appear to play an important role in the TLR response, with elevated cytokine levels following COX1 (show COX1 Antibodies)/2 inhibition or genetic deletion.
Data suggest deletion of Cox1 (show COX1 Antibodies) delays ovarian follicle development prior to reproductive maturation of mutant mouse strain (Wv); inhibition of Cox1 (show COX1 Antibodies) (but not Cox2 (show COX2 Antibodies)) may prolong ovarian follicle lifespan and delay the onset of premature ovarian failure.
role of COX-1 during maturation of adipocyte
The production of prostanoids found in the systemic circulation is driven overwhelmingly by COX-1 and not COX-2 (show COX2 Antibodies).
there was no expression of COX-1, either mRNA or protein, on any day of the estrous cycle
In Indian peptic ulcer hemorrhage patients, those with Cox-1 (show COX1 Antibodies) A842G polymorphisms tended to have less gastric ulcers among those with the A842G/C50T polymorphism.
inverse allosteric regulation likely underlies the ability of PGHS-2 (show PTGS2 Antibodies) to operate at low AA concentrations, when PGHS-1 is effectively latent.
PON1 (show PON1 Antibodies), P2Y12 (show P2RY12 Antibodies) and COX1 (show COX1 Antibodies) polymorphisms were associated with poorer vascular outcomes in patients with extracranial or intracranial stents.
The regulation of important oxylipin metabolic genes in peripheral blood mononuclear cells varied with the extent of change in arachidonic acid concentrations in the case of PTGS1 and ALOX12 (show ALOX12 Antibodies) regulation.
Immunohistochemical expression of COX-1 (show COX1 Antibodies) and VEGF (show VEGFA Antibodies) is associated with poor prognostic parameters in renal cell carcinoma (show MOK Antibodies).
over-expression of COX-1 (show COX1 Antibodies) in an aberrant manner intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer
COX-2 (show COX2 Antibodies) displays an enhanced facilitatory control on tachykininergic contractile activity in diverticular disease
Significant associations with NSAID-exacerbated respiratory disease were identified for: ALOX15 (show ALOX15 Antibodies) homozygous genotype and PTGS-1 rs5789 A/A homozygous genotype
Origin of the Enigmatic Stepwise Tight-Binding Inhibition of Cyclooxygenase-1.
cadmium at the highest tested concentrations modulates COX-1 (show COX1 Antibodies) and COX-2 (show COX2 Antibodies) at mRNA level in THP-1 (show GLI2 Antibodies) macrophages
Brain death increases the expression of COX-1 (show COX1 Antibodies) and COX-2 (show PTGS2 Antibodies) mRNA in the renal medulla
Endometrial prostaglandin-endoperoxide synthase 1 (PTGS1) mRNA expression increased 2- to 3-fold after Day 10 of the estrous cycle and pregnancy, whereas PTGS2 (show PTGS2 Antibodies) mRNA expression increased 76-fold between Days 5 and 15 of the estrous cycle and pregnancy.
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants.
, prostaglandin G/H synthase 1
, prostaglandin G/H synthase and cyclooxygenase
, prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
, PGH synthase 1
, PHS 1
, prostaglandin H2 synthase 1
, prostaglandin-endoperoxide synthase 1
, cyclooxygenase 1
, cyclooxygenase 3
, prostaglandin endoperoxide synthase