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anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) Antibodies

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. Additionally we are shipping Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Kits (62) and Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Proteins (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PTGS2 19225 Q05769
PTGS2 29527 P35355
PTGS2 5743 P35354
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Top anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Antibodies at antibodies-online.com

Showing 10 out of 235 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Rabbit Un-conjugated IHC (p) Formalin fixed paraffin embedded human colon carcinoma stained with COX2 antibody. ABIN115419 1 mL Log in to see 6 to 8 Days
$720.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of Cox-2 expression in Jurkat cell lysates. 100 μg Log in to see 2 to 3 Days
$283.50
Details
Human Rabbit Un-conjugated IHC (p) 7 mL Log in to see 2 to 3 Days
$286.00
Details
Cow Goat Un-conjugated EIA, WB 20 μg Log in to see 6 to 8 Days
$203.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Confocal immunofluorescent analysis of PTGS2 Antibody (Center P378) (ABIN655500) with A549 cell followed by Alexa Fluor® 489-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB Confocal immunofluorescent analysis of Cyclooxygenase 2 Antibody (Center) Cat.-No AP53500PU-N with A549 cell followed by Alexa Fluor®489-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). Formalin fixed and paraffin embedded human uterus tissue stained with Cyclooxygenase 2 Antibody (Center) followed by peroxidase conjugation of the secondary antibody and DAB staining 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p) 1 mL Log in to see 2 to 3 Days
$517.00
Details
Human Goat Un-conjugated ELISA, WB ABIN184672 staining (0.5µg/ml) of H460 lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Log in to see 4 to 5 Days
$326.89
Details
Chicken Mouse Biotin WB Western blot analysis of Cox-2 on lysate from mouse macrophages treated with IFNgamma and LPS. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of anti-Cox-2. 50 μg Log in to see 5 to 6 Days
$341.03
Details
Human Rabbit Un-conjugated IHC, IHC (p), SimWes, WB Formalin fixed paraffin embedded human colon carcinoma stained with COX2 antibody. Immunohistochemistry-Paraffin: COX-2 Antibody [ABIN152112] - Formalin fixed paraffin embedded human colon carcinoma stained with COX2 antibody. 0.5 mL Log in to see 5 to 7 Days
$447.56
Details

PTGS2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Antibodies

  1. Human Monoclonal PTGS2 Primary Antibody for IHC (p) - ABIN1687606 : Yang, Hsu, Meng, Su: Supplement of 5-hydroxytryptophan before induction suppresses inflammation and collagen-induced arthritis. in Arthritis research & therapy 2015 (PubMed)
    Show all 29 references for ABIN1687606

  2. Human Monoclonal PTGS2 Primary Antibody for IHC (p) - ABIN1687611 : Carvalho, Pires, Prada, Ferreira, Queiroga: Positive Interplay Between CD3+ T-lymphocytes and Concurrent COX-2/EGFR Expression in Canine Malignant Mammary Tumors. in Anticancer research 2015 (PubMed)
    Show all 24 references for ABIN1687611

  3. Human Polyclonal PTGS2 Primary Antibody for IHC, IHC (p) - ABIN152112 : Chu, Yeh, Lin, Jung, Ma, Wang, Wu, Shiu, Chen: Deletion of the FHL2 gene attenuating neovascularization after corneal injury. in Investigative ophthalmology & visual science 2008 (PubMed)
    Show all 14 references for ABIN152112

  4. Chicken Monoclonal PTGS2 Primary Antibody for WB - ABIN967824 : Hla, Neilson: Human cyclooxygenase-2 cDNA. in Proceedings of the National Academy of Sciences of the United States of America 1992 (PubMed)
    Show all 5 references for ABIN967824

  5. Human Polyclonal PTGS2 Primary Antibody for EIA, IF - ABIN951767 : Duggan, Walters, Musee, Harp, Kiefer, Oates, Marnett: Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. in The Journal of biological chemistry 2010 (PubMed)
    Show all 4 references for ABIN951767

  6. Mouse (Murine) Polyclonal PTGS2 Primary Antibody for IHC (p) - ABIN115419 : Cras, Martin, Gheuens: Gamma-enolase and glial fibrillary acidic protein in nervous system tumors. An immunohistochemical study using specific monoclonal antibodies. in Acta neuropathologica 1988 (PubMed)
    Show all 2 references for ABIN115419

  7. Human Polyclonal PTGS2 Primary Antibody for ELISA, WB - ABIN184672 : Ballif, Mincek, Barratt, Wilson, Simmons: Interaction of cyclooxygenases with an apoptosis- and autoimmunity-associated protein. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)

  8. Human Polyclonal PTGS2 Primary Antibody for WB - ABIN223087 : Majed, Rashid, Khan, Nafees, Ali, Ali, Khan, Hasan, Mehdi, Sultana: Tannic acid mitigates the DMBA/croton oil-induced skin cancer progression in mice. in Molecular and cellular biochemistry 2014 (PubMed)

More Antibodies against Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Interaction Partners

Horse (Equine) Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. This study showed that COX-1 (show PTGS1 Antibodies) and COX-2 in genital carcinomas in the horse is poor; microsomal PGES (show PTGES Antibodies)-1 is more prominently expressed.

  2. Progestin treatment does not affect expression of cytokines, steroid receptors, oxytocin receptor (show OXTR Antibodies), and cyclooxygenase 2 in fetal membranes and endometrium.

  3. COX-1 (show PTGS1 Antibodies) and COX-2 genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 gene expression at each subsequent time point, compared with baseline values.

  4. The role for p38 (show MAPK14 Antibodies) mitogen-activated kinase (MAPK (show MAPK1 Antibodies)) in the signaling mechanism regulating pro-inflammatory cyclooxygenase (COX (show CPOX Antibodies)) gene expression in lipopolysaccharide (LPS (show IRF6 Antibodies))-activated equine leukocytes in horses is reported.

  5. In this study, both COX-1 (show PTGS1 Antibodies) and COX-2 were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2.

  6. Immunoreactivity for COX-1 (show PTGS1 Antibodies) and COX-2 is high in equine corneal SCC (show CYP11A1 Antibodies), possibly indicating that COX (show CPOX Antibodies) plays a role in oncogenesis or progression of this tumor type at this site.

  7. It was found that most equine squamous-cell carcinomas and many melanomas appear to express COX-2 and thus could respond to COX-2 inhibitor therapy.

  8. data support the hypothesis that prostaglandin G/H synthase 2(PGHS2)is a target for the antiluteolytic signal produced by equine conceptuses during early pregnancy

Cow (Bovine) Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. results indicate that nuclear receptor subfamily 1 group D member 1(REV-ERBalpha (show NR1D1 Antibodies)) plays an inhibitory role in the expression of prostaglandin-endoperoxide synthase 2(PTGS2) in both bovine USCs and UECs treated with ovarian steroids

  2. This study showed that neutrophils from periparturient heifers show impairment of COX-2 mRNA expression and lactoferrin (show LTF Antibodies), suggesting that these mechanisms may contribute to immunosuppression in cows around calving.

  3. Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Antibodies) and PTGS2, and decreased the expression of SOD2 (show SOD2 Antibodies), GPX3 (show GPX3 Antibodies), DAB2 (show DAB2 Antibodies), and NR3C1 (show NR3C1 Antibodies). TNF (show TNF Antibodies) and IL6 (show IL6 Antibodies) levels were also decreased while those of NAMPT (show NAMPT Antibodies) were unaffected.

  4. Purinergic P2Y1 receptor (show P2RY1 Antibodies) signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts

  5. Data suggest that Escherichia coli infections (here, administration of LPS (show IRF6 Antibodies)) provokes luteolysis in diestrus, non-lactating cows but no change in expression of PTGS2 in corpus luteum and has no effect on luteinization in the following cycle.

  6. This study is the first to report the involvement of PGE2 in oocyte MAPK (show MAPK1 Antibodies) activation during the maturation process.

  7. Inhibitors of c-Src (show SRC Antibodies) (PP2, 10 microm) and PI3K (LY294002, 25 microm) produced a significant decrease in oxytocin-induced PGF (show PGF Antibodies)(2 alpha) production and reduced COX2 expression by endometrial epithelial cells.

  8. COX-2 pathway is responsible for the endometrial production of PGE (show LIPF Antibodies)(2) in the bovine endometrium during the estrous cycle

  9. the conceptus, through its secretion of IFN-tau, stimulates maternal epithelial expression of COX-2 and GM-CSF (show CSF2 Antibodies) during the peri (show PLIN1 Antibodies)-attachment period in the cow.

  10. the PGHS-2 promoter is regulated by bovine upstream stimulatory factor 1 (show USF1 Antibodies) and 2 in preovulatory granulosa cells

Mouse (Murine) Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. results suggest that Cox-2 (show COX2 Antibodies) is involved in the pathogenesis of noise-induced hearing loss; and pharmacological inhibition of Cox-2 (show COX2 Antibodies) has considerable therapeutic potential in noise-induced hearing loss.

  2. COX-2 (show COX2 Antibodies) and EP1 (show PTGER1 Antibodies) receptors participate in the increased extracellular matrix deposition and vascular stiffness, the impaired vascular function and inflammation in hypertension. Targeting PGE2 receptors might have benefits in hypertension-associated vascular damage.

  3. The higher iNOS (show NOS2 Antibodies) inhibition activity of the tested Schiff bases, relative to that of COX-2 (show COX2 Antibodies), seems to be a reflection of the combined suppressive effects exerted by their nalidixic acid, isatins (4a-c), and l-amino acid moieties against iNOS (show NOS2 Antibodies) expression.

  4. these results not only provide a dataset of protein expression change in FA treatment but also suggest that Cox-2 (show COX2 Antibodies) and lipid droplets (LDs) are potential players in PA- and OA-mediated cellular processes

  5. prostaglandin E2 (PGE2) as a damage-associated molecular pattern that negatively regulates immune responses. The production of PGE2 is augmented under cell death-inducing conditions via the transcriptional induction of the cyclooxygenase 2 gene and cell-released PGE2 suppresses the expression of genes associated with inflammation, thereby limiting the cell's immunostimulatory activities.

  6. DHA and celecoxib diminished the COX-2 (show COX2 Antibodies) and iNOS (show NOS2 Antibodies) expression in the cells. This was associated with increased PPARgamma (show PPARG Antibodies) activity, supressed NF-kappaB (show NFKB1 Antibodies) activity in the nucleus.

  7. role of cyclooxygenase-1 (show PTGS1 Antibodies) and -2 in endothelium-dependent contraction of atherosclerotic mouse abdominal aortas

  8. Tat (show TAT Antibodies)-SOD inhibited SNP-induced COX-2 (show COX2 Antibodies) expression similarly to celecoxib and prevented the formation of peroxynitrite as 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide.

  9. Findings suggest that COX-2 (show COX2 Antibodies) deletion contributes to the repression of K-ras (show HRAS Antibodies)-induced lung tumorigenesis by reducing tumor cell proliferation, decreasing the production of PGE2, and increasing the production of 13,14-dihydro-15-keto-PGE2, possibly via the MAPK (show MAPK1 Antibodies) pathway.

  10. Glucose-related hyperosmolarity seems to be able to promote angiogenesis and retinopathy through activation of TonEBP (show NFAT5 Antibodies) and possibly increasing expression of AQP1 (show AQP1 Antibodies) and COX-2 (show COX2 Antibodies).

Human Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. In gastric adenocarcinoma, COX-2 expression might serve as a powerful indicator for intestinal type carcinoma, locally advanced disease and H. pylori infection, while VEGF was related to loco-regional progression. COX-2 might be involved in the development of angiogenesis in gastric carcinoma through VEGF upregulation.

  2. We evaluated the association between COX-2 (show COX2 Antibodies) polymorphisms and prognosis of hepatocellular carcinoma. We found that patients with the COX-2 (show COX2 Antibodies) -1195AG and -1195AG + AA genotypes and demonstrated significantly decreased disease-free survival (DFS (show FST Antibodies)) as compared with those carrying the -1195GG genotype.

  3. According to the present published data, Cox-2 (show COX2 Antibodies) expression was closely correlated to skin cancer.

  4. The significant correlation of VEGF expression with COX-2 expression and mast cell density may represent the roles of COX-2 and mast cell density in tumor angiogenesis by modulating VEGF production.

  5. COX2 (show COX2 Antibodies) was expressed in a significantly higher proportion of apocrine lesions than of normal glands

  6. Findings suggest that P50 (show CD40 Antibodies)-associated COX-2 (show COX2 Antibodies) extragenic RNA (PACER) promotes proliferation and metastasis of osteosarcoma cells by activating the cyclooxygenase-2 (COX-2) gene and its own expression was influenced by DNA methylation (show HELLS Antibodies).

  7. we conclude that resveratrol inhibits the proliferation of MCF-7 cells by TTP (show ADAMTS13 Antibodies) upregulation, which is associated with downregulation of COX-2 (show COX2 Antibodies) and VEGF (show VEGFA Antibodies) and upregulation of iNOS (show NOS2 Antibodies).

  8. Data show that alpha-linolenic acid (ALA) decreased the expression of VEGF (show VEGFA Antibodies) and COX2 (show COX2 Antibodies) proteins, and reduced the expression of Human papillomavirus type 16/18 onco-proteins E6 and E7, resulting into restoration of expression of tumor suppressor proteins, p53 (show TP53 Antibodies) and Rb in cervical cancer cell lines.

  9. COX-2 (show COX2 Antibodies) rs5277 C allele increases the risk of left main coronary artery lesion and is also correlated with poor prognosis of Left Main Coronary Artery Disease patients with CABG therapy.

  10. Our findings emphasize the importance of COX-2 (show COX2 Antibodies) as a potential marker of tumor progression and prognosis in GC, and that the inhibition of COX-2 (show COX2 Antibodies) activity may have a therapeutic benefit in GC.

Pig (Porcine) Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. These findings suggest that nuclear factor kappa B(NF-kappaB (show NFKB1 Antibodies)) and cyclooxygenase-2 play roles in epidermal cell regeneration following beta-irradiation of mini-pig skin.

  2. COX2 expression is upregulated in CAVD, and its activity contributes to osteogenic gene induction and valve calcification in vitro and in vivo.

  3. These results suggest that COX-2 plays a role in the pathogenesis of Mycoplasma hyopneumoniae -infection.

  4. Brain death increases the expression of COX-1 (show COX1 Antibodies) and COX-2 mRNA in the renal medulla

  5. COX-2 is differentially expressed in normal versus lungworm-infected lungs of pigs and is likely to be involved in the pathogenesis of porcine parasitic bronchopneumonia.

  6. In porcine vas (show AVP Antibodies) deferens epithelial cell monolayers, increases in anion secretion were associated with preferential upregulation of PTGS2 at the mRNA and protein levels.

  7. expression appears to be positively and negatively regulated by p38 MAPK (show MAPK14 Antibodies) and JNK (show MAPK8 Antibodies) pathways; alternatively, ERK1/2 (show MAPK1/3 Antibodies) appear to be involved in COX-2-independent reparative events that remain to be defined

  8. Neutrophils augment recovery of transepithelial electrical resistance in ischemia-injured ileal mucosa via IL-1beta (show IL1B Antibodies)-dependent upregulation of COX-2. (Cyclooxygenase 2)

  9. Administration of estrogen early in pregnancy alters endometrial prostaglandin-endoperoxide synthase 2 (PTGS2) mRNA and protein expression, which may disrupt pregnancy causing total embryonic loss during implantation in the pig.

  10. The effect of EGF (show EGF Antibodies) on pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha (show TNF Antibodies)) and cyclooxygenase-2 (COX-2), levels during wound healing in swine is reported.

Rabbit Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta (show IL1B Antibodies),COX-2 (show COX2 Antibodies), and TGFbeta1 (show TGFB1 Antibodies)

  2. The result demonstrate that mechanical stress on synovial cells induces gene expressions of COX-2 (show COX2 Antibodies).

  3. Diabetes enhances the vasodilator response of the rabbit carotid artery to testosterone by a mechanism that includes an increased modulatory activity of the endothelial nitric oxide and an augmented release of COX-2 (show COX2 Antibodies) vasodilator, prostacyclin.

  4. Local induction of COX-2 (show COX2 Antibodies) during atherosclerosis decreased the sensitivity to norepinephrine and that COX-2 (show COX2 Antibodies) inhibitors may increase vascular reactivity at sites of atherosclerotic lesions.

Goat Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. The vesicular gland of castrated goats showed significantly lower AR and COX-2 (show COX2 Antibodies) immuno-expression than intact goats indicating that both AR and COX-2 (show COX2 Antibodies) are androgen dependent.

Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) Antigen Profile

Protein Summary

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.

Gene names and symbols associated with PTGS2

  • cyclooxygenase-2 (COX-2) antibody
  • prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2) antibody
  • cyclooxygenase-2 (cox-2) antibody
  • cyclooxygenase 2 (cox-2) antibody
  • prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (ptgs2) antibody
  • cytochrome c oxidase subunit II (COX2) antibody
  • olfactory receptor, family 2, subfamily W, member 1-like (LOC782475) antibody
  • prostaglandin-endoperoxide synthase 2 (Ptgs2) antibody
  • CEF147 antibody
  • COII antibody
  • Cox-2 antibody
  • Cox2 antibody
  • GRIPGHS antibody
  • hCox-2 antibody
  • PGG/HS antibody
  • PGHS-2 antibody
  • PGHS2 antibody
  • PHS-2 antibody
  • PHSII antibody
  • PTGS2 antibody
  • TIS10 antibody

Protein level used designations for PTGS2

cyclooxygenase-2 , cyclooxygenase 2 , prostaglandin G/H synthase 2 , prostaglandin G/H synthase and cyclooxygenase , prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) , prostaglandin G/H synthase 2-like , PES-2 , PGH synthase 2 , PHS II , glucocorticoid-regulated inflammatory cyclooxygenase , gripghs , macrophage activation-associated marker protein P71/73 , prostaglandin H2 synthase 2 , PGHS-2 , cyclooxygenase 2b , COX-2 , prostaglandin G/H synthase-2 , cyclooxygenase, prostaglandin endoperoxide H synthase-2 , prostaglandin H synthase-2 , cyclooxygenase type 2 , mitogen-inducible PGHS

GENE ID SPECIES
100033836 Equus caballus
100126581 Felis catus
100136025 Oncorhynchus mykiss
100136456 Salmo salar
446781 Xenopus laevis
469616 Pan troglodytes
595089 Xenopus (Silurana) tropicalis
716671 Macaca mulatta
100407639 Callithrix jacchus
100436566 Pongo abelii
807845 Equus caballus
808252 Ovis aries
782475 Bos taurus
19225 Mus musculus
29527 Rattus norvegicus
100135607 Cavia porcellus
5743 Homo sapiens
282023 Bos taurus
791253 Equus caballus
443460 Ovis aries
442942 Canis lupus familiaris
397590 Sus scrofa
100009248 Oryctolagus cuniculus
396451 Gallus gallus
100860905 Capra hircus
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