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Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Proteins (PTGS2)

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. Additionally we are shipping Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Antibodies (222) and Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Kits (77) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTGS2 19225 Q05769
PTGS2 29527 P35355
PTGS2 5743 P35354
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Top Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Proteins at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Baculovirus infected Insect Cells Human His tag 50 μg Log in to see 16 Days
$382.80
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HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$633.60
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HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$668.80
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,688.67
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$841.86
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details

PTGS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , ,
, ,

More Proteins for Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) Interaction Partners

Horse (Equine) Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. This study showed that COX-1 (show PTGS1 Proteins) and COX-2 in genital carcinomas in the horse is poor; microsomal PGES (show PTGES Proteins)-1 is more prominently expressed.

  2. Progestin treatment does not affect expression of cytokines, steroid receptors, oxytocin receptor (show OXTR Proteins), and cyclooxygenase 2 in fetal membranes and endometrium.

  3. COX-1 (show PTGS1 Proteins) and COX-2 genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 gene expression at each subsequent time point, compared with baseline values.

  4. The role for p38 (show MAPK14 Proteins) mitogen-activated kinase (MAPK (show MAPK1 Proteins)) in the signaling mechanism regulating pro-inflammatory cyclooxygenase (COX (show CPOX Proteins)) gene expression in lipopolysaccharide (LPS (show IRF6 Proteins))-activated equine leukocytes in horses is reported.

  5. In this study, both COX-1 (show PTGS1 Proteins) and COX-2 were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2.

  6. Immunoreactivity for COX-1 (show PTGS1 Proteins) and COX-2 is high in equine corneal SCC (show CYP11A1 Proteins), possibly indicating that COX (show CPOX Proteins) plays a role in oncogenesis or progression of this tumor type at this site.

  7. It was found that most equine squamous-cell carcinomas and many melanomas appear to express COX-2 and thus could respond to COX-2 inhibitor therapy.

  8. data support the hypothesis that prostaglandin G/H synthase 2(PGHS2)is a target for the antiluteolytic signal produced by equine conceptuses during early pregnancy

Cow (Bovine) Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. results indicate that nuclear receptor subfamily 1 group D member 1(REV-ERBalpha (show NR1D1 Proteins)) plays an inhibitory role in the expression of prostaglandin-endoperoxide synthase 2(PTGS2) in both bovine USCs and UECs treated with ovarian steroids

  2. This study showed that neutrophils from periparturient heifers show impairment of COX-2 mRNA expression and lactoferrin (show LTF Proteins), suggesting that these mechanisms may contribute to immunosuppression in cows around calving.

  3. Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2, and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1 (show NR3C1 Proteins). TNF (show TNF Proteins) and IL6 (show IL6 Proteins) levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.

  4. Purinergic P2Y1 receptor (show P2RY1 Proteins) signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts

  5. Data suggest that Escherichia coli infections (here, administration of LPS (show IRF6 Proteins)) provokes luteolysis in diestrus, non-lactating cows but no change in expression of PTGS2 in corpus luteum and has no effect on luteinization in the following cycle.

  6. This study is the first to report the involvement of PGE2 in oocyte MAPK (show MAPK1 Proteins) activation during the maturation process.

  7. Inhibitors of c-Src (show SRC Proteins) (PP2, 10 microm) and PI3K (LY294002, 25 microm) produced a significant decrease in oxytocin-induced PGF (show PGF Proteins)(2 alpha) production and reduced COX2 expression by endometrial epithelial cells.

  8. COX-2 pathway is responsible for the endometrial production of PGE (show LIPF Proteins)(2) in the bovine endometrium during the estrous cycle

  9. the conceptus, through its secretion of IFN-tau, stimulates maternal epithelial expression of COX-2 and GM-CSF (show CSF2 Proteins) during the peri (show PLIN1 Proteins)-attachment period in the cow.

  10. the PGHS-2 promoter is regulated by bovine upstream stimulatory factor 1 (show USF1 Proteins) and 2 in preovulatory granulosa cells

Mouse (Murine) Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. role of cyclooxygenase-1 (show PTGS1 Proteins) and -2 in endothelium-dependent contraction of atherosclerotic mouse abdominal aortas

  2. Tat (show TAT Proteins)-SOD inhibited SNP-induced COX-2 expression similarly to celecoxib and prevented the formation of peroxynitrite as 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide.

  3. Findings suggest that COX-2 deletion contributes to the repression of K-ras (show HRAS Proteins)-induced lung tumorigenesis by reducing tumor cell proliferation, decreasing the production of PGE2, and increasing the production of 13,14-dihydro-15-keto-PGE2, possibly via the MAPK (show MAPK1 Proteins) pathway.

  4. Glucose-related hyperosmolarity seems to be able to promote angiogenesis and retinopathy through activation of TonEBP (show NFAT5 Proteins) and possibly increasing expression of AQP1 (show AQP1 Proteins) and COX-2.

  5. COX-2 has a direct role in modulating tumor progression in tumors arising within collagen-dense microenvironments, and suggest that COX-2 may be an effective therapeutic target for women with dense breast tissue and early-stage breast cancer.

  6. COX-2 deletion delays BM megakaryopoiesis promoting compensatory splenic MK hyperplasia, releasing hyper-responsive platelets increasing thrombogenicity. COX-2 contributes to MK maturation and pro-platelet formation.

  7. Suggest the expression of COX-1 (show PTGS1 Proteins) and COX-2 in the urothelium protects bladder damage from radiation.

  8. Ptgs2 mRNAs increased within 5 h after injury in mouse cortical slices.

  9. Modulation of COX-2-driven metabolization of 2-AG may provide a novel physiological concept allowing the specific targeting of HSCs in liver fibrosis.

  10. alveolar type II cell-derived COX-2 plays an important role in regulating basal airway function and LPS (show TLR4 Proteins)-induced lung inflammation

Human Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. These findings demonstrate that Tan-IIA inhibits the migration ability of AGS (show JAG1 Proteins) human gastric cancer cells and that decreasing the protein expression of NF-kappaB (show NFKB1 Proteins)-p65 (show GORASP1 Proteins), COX-2, and MMP-2 (show MMP2 Proteins), -7 and -9 may be an underlying molecular mechanism

  2. our data suggest that the inhibition of both COX-2/5-LOX (show ALOX5 Proteins) may be an effective therapeutic approach for colon cancer management, particularly for those patients with high expression of COX-2/5-LOX (show ALOX5 Proteins)

  3. COX2 -1195G>A polymorphism might play a protective role in the onset of Parkinson disease and G-A-C haplotype in this three promoter region polymorphisms also showed a negative association.

  4. High PTGS2 expression is associated with Thyroid cancer.

  5. NFKB1 (show NFKB1 Proteins) -94 ins (show INS Proteins)/del and COX-2 (-1195G>A) polymorphisms may be, respectively, associated with decreased and increased prostate cancer risk in the Chinese population.

  6. Findings suggest that COX-2 deletion contributes to the repression of K-ras (show HRAS Proteins)-induced lung tumorigenesis by reducing tumor cell proliferation, decreasing the production of PGE2, and increasing the production of 13,14-dihydro-15-keto-PGE2, possibly via the MAPK (show MAPK1 Proteins) pathway.

  7. The findings of this study indicated that COX-2/PGE2 may be associated with the Middle Cerebral Artery occlusion and the hemorrhagic stroke in patients with Moyamoya Disease.

  8. Glucose-related hyperosmolarity seems to be able to promote angiogenesis and retinopathy through activation of TonEBP (show NFAT5 Proteins) and possibly increasing expression of AQP1 (show AQP1 Proteins) and COX-2.

  9. Results show a platelets cancer cells cross-talk involving an aberrant expression of COX-2 which influences cell-cycle progression and contributes to the acquisition of a cell migratory phenotype through the induction of epithelial mesenchymal transition.

  10. The aim of this study was to investigate the association between cyclooxygenase-2 (COX-2) rs689466 (-1195 G>A) polymorphism and susceptibility to head and neck squamous cell carcinoma (HNSCC) by performing a meta-analysis

Pig (Porcine) Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. These findings suggest that nuclear factor kappa B(NF-kappaB (show NFKB1 Proteins)) and cyclooxygenase-2 play roles in epidermal cell regeneration following beta-irradiation of mini-pig skin.

  2. COX2 expression is upregulated in CAVD, and its activity contributes to osteogenic gene induction and valve calcification in vitro and in vivo.

  3. These results suggest that COX-2 plays a role in the pathogenesis of Mycoplasma hyopneumoniae -infection.

  4. Brain death increases the expression of COX-1 and COX-2 mRNA in the renal medulla

  5. COX-2 is differentially expressed in normal versus lungworm-infected lungs of pigs and is likely to be involved in the pathogenesis of porcine parasitic bronchopneumonia.

  6. In porcine vas (show AVP Proteins) deferens epithelial cell monolayers, increases in anion secretion were associated with preferential upregulation of PTGS2 at the mRNA and protein levels.

  7. expression appears to be positively and negatively regulated by p38 MAPK (show MAPK14 Proteins) and JNK (show MAPK8 Proteins) pathways; alternatively, ERK1/2 appear to be involved in COX-2-independent reparative events that remain to be defined

  8. Neutrophils augment recovery of transepithelial electrical resistance in ischemia-injured ileal mucosa via IL-1beta (show IL1B Proteins)-dependent upregulation of COX-2. (Cyclooxygenase 2)

  9. Administration of estrogen early in pregnancy alters endometrial prostaglandin-endoperoxide synthase 2 (PTGS2) mRNA and protein expression, which may disrupt pregnancy causing total embryonic loss during implantation in the pig.

  10. The effect of EGF (show EGF Proteins) on pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha (show TNF Proteins)) and cyclooxygenase-2 (COX-2), levels during wound healing in swine is reported.

Rabbit Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) interaction partners

  1. results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta (show IL1B Proteins),COX-2, and TGFbeta1 (show TGFB1 Proteins)

  2. The result demonstrate that mechanical stress on synovial cells induces gene expressions of COX-2.

  3. Diabetes enhances the vasodilator response of the rabbit carotid artery to testosterone by a mechanism that includes an increased modulatory activity of the endothelial nitric oxide and an augmented release of COX-2 vasodilator, prostacyclin.

  4. Local induction of COX-2 during atherosclerosis decreased the sensitivity to norepinephrine and that COX-2 inhibitors may increase vascular reactivity at sites of atherosclerotic lesions.

Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2) Protein Profile

Protein Summary

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.

Gene names and symbols associated with PTGS2

  • cyclooxygenase-2 (COX-2)
  • prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2)
  • cyclooxygenase-2 (cox-2)
  • cyclooxygenase 2 (cox-2)
  • prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (ptgs2)
  • cytochrome c oxidase subunit II (COX2)
  • olfactory receptor, family 2, subfamily W, member 1-like (LOC782475)
  • prostaglandin-endoperoxide synthase 2 (Ptgs2)
  • CEF147 protein
  • COII protein
  • Cox-2 protein
  • Cox2 protein
  • GRIPGHS protein
  • hCox-2 protein
  • PGG/HS protein
  • PGHS-2 protein
  • PGHS2 protein
  • PHS-2 protein
  • PHSII protein
  • PTGS2 protein
  • TIS10 protein

Protein level used designations for PTGS2

cyclooxygenase-2 , cyclooxygenase 2 , prostaglandin G/H synthase 2 , prostaglandin G/H synthase and cyclooxygenase , prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) , prostaglandin G/H synthase 2-like , PES-2 , PGH synthase 2 , PHS II , glucocorticoid-regulated inflammatory cyclooxygenase , gripghs , macrophage activation-associated marker protein P71/73 , prostaglandin H2 synthase 2 , PGHS-2 , cyclooxygenase 2b , COX-2 , prostaglandin G/H synthase-2 , cyclooxygenase, prostaglandin endoperoxide H synthase-2 , prostaglandin H synthase-2 , cyclooxygenase type 2 , mitogen-inducible PGHS

GENE ID SPECIES
100033836 Equus caballus
100126581 Felis catus
100136025 Oncorhynchus mykiss
100136456 Salmo salar
446781 Xenopus laevis
469616 Pan troglodytes
595089 Xenopus (Silurana) tropicalis
716671 Macaca mulatta
100407639 Callithrix jacchus
100436566 Pongo abelii
807845 Equus caballus
808252 Ovis aries
782475 Bos taurus
19225 Mus musculus
29527 Rattus norvegicus
100135607 Cavia porcellus
5743 Homo sapiens
282023 Bos taurus
791253 Equus caballus
443460 Ovis aries
442942 Canis lupus familiaris
397590 Sus scrofa
100009248 Oryctolagus cuniculus
396451 Gallus gallus
100860905 Capra hircus
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