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PMEPA1 encodes a transmembrane protein that contains a Smad interacting motif (SIM). Additionally we are shipping PMEPA1 Proteins (8) and PMEPA1 Kits (2) and many more products for this protein.
Showing 10 out of 23 products:
Human Monoclonal PMEPA1 Primary Antibody for ELISA, WB - ABIN566055
Hirokawa, Takagi, Uchida, Kozuka, Yoneda, Watanabe, Shiraishi: High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone. in Cellular & molecular biology letters 2012
Show all 8 references for ABIN566055
Human Polyclonal PMEPA1 Primary Antibody for EIA, IF - ABIN954212
Li, Xu, Masuda, Raymundo, McLeod, Dobi, Srivastava: A feedback loop between the androgen receptor and a NEDD4-binding protein, PMEPA1, in prostate cancer cells. in The Journal of biological chemistry 2008
Show all 2 references for ABIN954212
Human Polyclonal PMEPA1 Primary Antibody for DB, EIA - ABIN493520
Richter, Masuda, Cook, Ehrich, Tadese, Li, Owusu, Srivastava, Dobi: A role for DNA methylation in regulating the growth suppressor PMEPA1 gene in prostate cancer. in Epigenetics : official journal of the DNA Methylation Society 2008
Show all 2 references for ABIN493520
Data show that over-expressed transmembrane prostate androgen-induced protein 1 (PMEPA1) can promote cell migration and maintain the mesenchymal-like morphology of breast cancer cells.
Data show that silencing of PMEPA1 protein facilitates the growth of prostate cancer cells and modulates androgen receptor (AR (show AR Antibodies)) through NEDD4 (show NEDD4 Antibodies) ubiquitin protein ligase (show UBE2K Antibodies) and PTEN (show PTEN Antibodies) protein.
Downregulation of PMEPA1 may result in increased androgen receptor (show AR Antibodies) protein levels and function in cancer of the prostate cells, contributing to prostate tumorigenesis.
EGF (show EGF Antibodies) signaling collaboratively regulates TGF-beta (show TGFB1 Antibodies)-induced TMEPAI expression.
TMEPAI is translocated on the lysosome and late endosome, and that association with Nedd4 (show NEDD4 Antibodies) is required for the transport of TMEPAI to the lysosome.
TMEPAI promotes tumorigenic activities in lung cancer cells.
The levels of TMEPAI in lung tumor tissues are very high.
Differentially expressed genes were identified, including E-cadherin (show CDH1 Antibodies), IL-8 (show IL8 Antibodies) and STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 (show PCSK1 Antibodies) subclone.
Results suggest that TMEPAI functions in breast cancer as a molecular switch that converts TGF-beta (show TGFB1 Antibodies) from a tumor suppressor to a tumor promoter.
Expression of PMEPA1 was well maintained both in colon cancer primary tumors and in colon cancer liver metastases.
Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies)/TCF7L2 (show TCF7L2 Antibodies) pathway is preferentially able to alter the transcriptional regulation of the TGF-beta (show TGFB1 Antibodies)-target gene, TMEPAI.
This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
transmembrane prostate androgen-induced protein
, transmembrane, prostate androgen induced RNA
, prostate transmembrane protein, androgen induced 1
, solid tumor-associated 1 protein
, NEDD4 WW domain-binding protein 4
, Nedd4 WW binding protein 4