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PMEPA1 encodes a transmembrane protein that contains a Smad interacting motif (SIM). Additionally we are shipping PMEPA1 Antibodies (25) and PMEPA1 Kits (2) and many more products for this protein.
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these data elaborated on the diverse activity among TCF (show HNF4A Proteins)/LEF family members with respect to the transcriptional regulation of the TMEPAI gene.
Data show that over-expressed transmembrane prostate androgen-induced protein 1 (PMEPA1) can promote cell migration and maintain the mesenchymal-like morphology of breast cancer cells.
Data show that silencing of PMEPA1 protein facilitates the growth of prostate cancer cells and modulates androgen receptor (AR (show AR Proteins)) through NEDD4 (show NEDD4 Proteins) ubiquitin protein ligase (show UBE2K Proteins) and PTEN protein.
Downregulation of PMEPA1 may result in increased androgen receptor (show AR Proteins) protein levels and function in cancer of the prostate cells, contributing to prostate tumorigenesis.
EGF (show EGF Proteins) signaling collaboratively regulates TGF-beta (show TGFB1 Proteins)-induced TMEPAI expression.
TMEPAI is translocated on the lysosome and late endosome, and that association with Nedd4 (show NEDD4 Proteins) is required for the transport of TMEPAI to the lysosome.
TMEPAI promotes tumorigenic activities in lung cancer cells.
The levels of TMEPAI in lung tumor tissues are very high.
Differentially expressed genes were identified, including E-cadherin (show CDH1 Proteins), IL-8 (show IL8 Proteins) and STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 (show PCSK1 Proteins) subclone.
Results suggest that TMEPAI functions in breast cancer as a molecular switch that converts TGF-beta (show TGFB1 Proteins) from a tumor suppressor to a tumor promoter.
Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)/TCF7L2 (show TCF7L2 Proteins) pathway is preferentially able to alter the transcriptional regulation of the TGF-beta (show TGFB1 Proteins)-target gene, TMEPAI.
This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
transmembrane prostate androgen-induced protein
, transmembrane, prostate androgen induced RNA
, prostate transmembrane protein, androgen induced 1
, solid tumor-associated 1 protein
, NEDD4 WW domain-binding protein 4
, Nedd4 WW binding protein 4