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Protease, Serine, 21 (Testisin) Proteins (PRSS21)

PRSS21 encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. Additionally we are shipping PRSS21 Antibodies (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat PRSS21 PRSS21 353251  
PRSS21 57256 Q9JHJ7
PRSS21 10942 Q9Y6M0
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Top PRSS21 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

PRSS21 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Protease, Serine, 21 (Testisin) (PRSS21) Interaction Partners

Mouse (Murine) Protease, Serine, 21 (Testisin) (PRSS21) interaction partners

  1. ACR (show ACR Proteins) or PRSS21 or both may function cooperatively with SPAM1 (show SPAM1 Proteins) in sperm/cumulus penetration

  2. These data demonstrate that the trypsinlike protease activity of ACR (show ACR Proteins) and PRSS21 is essential for the process of sperm penetration through the cumulus matrix and zona pellucida in vitro

  3. The reduced fertility of Prss21-null epididymal sperm was rescued by exposure of the sperm to the uterine microenvironment and by in vitro treatment of the sperm with uterine fluids.

Human Protease, Serine, 21 (Testisin) (PRSS21) interaction partners

  1. Testisin activates PAR-2 (show F2RL1 Proteins), inducing PAR-2 (show F2RL1 Proteins) loss from the cell surface, internalization, and cellular signaling.

  2. Testisin may promote carcinogenesis by inhibiting tumor suppressor activity of maspin (show SERPINB5 Proteins).

  3. Loss of Testisin is caused, at least in part, by DNA hypermethylation and histone deacetylation, and suggest a tumour suppressor role for Testisin in testicular tumorigenesis.

  4. The results demonstrate for the first time that aberrant methylation of specific CpG sites near the transcription initiation site is an important factor in testisin gene silencing in TGCT.

  5. These data suggest that aberrant regulation of PRSS21 may underlie certain secondary male infertility syndromes, such as "easily decapitated" spermatozoa in humans.

PRSS21 Protein Profile

Protein Summary

This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with PRSS21

  • protease, serine, 21 (Prss21)
  • protease, serine, 21 (testisin) (PRSS21)
  • protease, serine, 41 (Prss41)
  • 1700023E12Rik protein
  • ESP-1 protein
  • ESP1 protein
  • mT4 protein
  • Resp-1 protein
  • RGD1304769 protein
  • TESP5 protein
  • Tessp1 protein
  • TEST1 protein
  • TESTISIN protein

Protein level used designations for PRSS21

eosinophil serine protease-1 , testisin , protease, serine, 21 (testisin) , testis serine protease 1 , testis-specific serine protease 1 , serine protease 21 , testicular serine protease 5 , tryptase 4 , eosinophil serine protease 1 , serine protease from eosinophils

GENE ID SPECIES
353251 Rattus norvegicus
479874 Canis lupus familiaris
528479 Bos taurus
699296 Macaca mulatta
681033 Rattus norvegicus
57256 Mus musculus
10942 Homo sapiens
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