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PRSS8 encodes a trypsinogen, which is a member of the trypsin family of serine proteases. Additionally we are shipping Protease, serine, 8 Kits (25) and Protease, serine, 8 Proteins (15) and many more products for this protein.
Showing 10 out of 91 products:
Human Monoclonal PRSS8 Primary Antibody for IF, WB - ABIN968773
Chen, Hodge, Guarda, Welch, Greenberg, Chai: Down-regulation of prostasin serine protease: a potential invasion suppressor in prostate cancer. in The Prostate 2001
Show all 4 references for ABIN968773
Human Polyclonal PRSS8 Primary Antibody for IHC, IHC (p) - ABIN441590
Sherman-Baust, Becker, Wood Iii, Zhang, Morin: Gene expression and pathway analysis of ovarian cancer cells selected for resistance to cisplatin, paclitaxel, or doxorubicin. in Journal of ovarian research 2012
PRSS8 may serve as a tumour suppressor in hepatocellular carcinoma progression.
Overexpression of PRSS8 mRNA and high levels of prostasin in multiple subtypes of early stage ovarian tumors may provide clinical biomarkers for early detection of ovarian cancer.
It is concluded that prostasin protein level change is less likely to be causally involved in placental dysfunction in preeclampsia.
In urinary exosomes, NCC (show SLC12A3 Antibodies) and prostasin had a diurnal pattern parallel to ADH (show AVP Antibodies) and aquaporin 2 (show AQP2 Antibodies), confirming that, in healthy subjects, both prostasin and NCC (show SLC12A3 Antibodies) relate to water balance.
Polymorphism of the prostasin gene is closely associated with poor pregnancy outcomes of early-onset severe preeclampsia.
Prostasin regulate the Lin28 (show LIN28A Antibodies)/Let-7 loop in ovarian cancer cells.
The higher frequency of C allele of prostasin gene at rs12597511 is associated with severe preeclampsia.
Prostasin repress cancer cells and contribute to chemoresistance by modulating the CASP (show CUX1 Antibodies)/PAK2-p34 (show PAK2 Antibodies)/actin pathway.
Our study suggested that Axl (show AXL Antibodies) and prostasin expression may be closely related to carcinogenesis, metastasis, and prognosis of ovarian adenocarcinoma.
urinary prostasin correlates with the aldosterone to renin (show REN Antibodies) ratio, and it is physiologically modulated by natriuresis in normotensive individuals
a proteolysis-dependent function of activated prostasin in hair follicles, dependent on zymogen conversion by matriptase (show ST14 Antibodies).
The claudin-4 (show CLDN4 Antibodies)-mediated chloride conductance can be regulated endogenously by a protease-channel-activating protease 1 (cap1).
HAI-1 (show SPINT1 Antibodies) regulates the activity of activated matriptase (show ST14 Antibodies), whereas HAI-2 (show SPINT2 Antibodies) has an essential role in regulating prostasin-dependent matriptase (show ST14 Antibodies) zymogen activation.
a novel inhibitory interaction between CAP1/Prss8 and nexin-1 (show SERPINE2 Antibodies), opening the search for specific CAP1/Prss8 antagonists that are independent of its catalytic activity
Data indicate that liver-specific serine protease (show F2 Antibodies) prostasin (PRSS8) knockout (LKO) mice develop insulin (show INS Antibodies) resistance associated with the increase in hepatic Toll-like receptor 4 (TLR4 (show TLR4 Antibodies)).
Data indicate that serine protease (show F2 Antibodies) prostasin (CAP1/PRSS8) supports terminal epidermal differentiation through a non-catalytic mechanism.
mutations in Prss8 restored placentation and normal development of HAI-1 (show SPINT1 Antibodies)-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2 (show SPINT2 Antibodies)-deficient embryos.
Mutations of the serine protease (show F2 Antibodies) CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC (show SCNN1A Antibodies) activity.
The T to A mutation at residue 170 (Val to Asp (show C3 Antibodies)) in Prss8 is responsible for the mutant frizzy (fr) phenotype.
Deficiency of CAP1/Prss8 in alveolar epithelial cells induced in vitro a 40% decrease in epithelial sodium channel-mediated sodium currents.
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.
channel-activating protease 1
, serine protease 8
, channel activating protease 1