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Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 Proteins (PSMC2)

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. Additionally we are shipping Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 Antibodies (73) and Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PSMC2 84705 Q969Y2
PSMC2 19181  
Rat PSMC2 PSMC2 25581 Q63347
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Top Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$721.60
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$3,206.50
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Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,206.50
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,210.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$904.80
Details

PSMC2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

More Proteins for Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2) Interaction Partners

Human Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2) interaction partners

  1. GTPBP3 (show GTPBP3 Proteins) defective expression is associated with an mitochondrial-tRNA hypomodification status.GTPBP3 plays a role in the regulation of UCP2 (show UCP2 Proteins) and MCP1 (show CCL2 Proteins) proteins through AMPK (show PRKAA1 Proteins) signaling.

  2. Results show that post-transcriptional expression of GTPBP3 (show GTPBP3 Proteins), MTO1 and TRMU (show TRMU Proteins) genes is down-regulated, leading to mt-tRNA hypomodification and contributing to mitochondrial dysfunction in MELAS cybrids.

  3. Most individuals with GTPBP3 (show GTPBP3 Proteins) mutations developed neurological symptoms and MRI (show C7ORF49 Proteins) involvement of thalamus, putamen, and brainstem resembling Leigh syndrome.

  4. GTPBP3 localizes in the mitochondria and is a deafness-associated homolog of yeast MSS1.

  5. Phenotype of non-syndromic deafness associated with the mitochondrial A1555G mutation is modulated by mitochondrial RNA modifying enzymes MTO1 and GTPBP3 (show GTPBP3 Proteins).

  6. Data show that the two most abundant GTPBP3 (show GTPBP3 Proteins) isoforms exhibit moderate affinity for guanine nucleotides like their bacterial homologue, MnmE, although they hydrolyze GTP (show AK3 Proteins) at a 100-fold lower rate.

  7. structural determinants for the binding of ubiquitin-like domains to 26s proteasome (show Psmd4 Proteins)

Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2) Protein Profile

Protein Summary

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with PSMC2

  • 26S protease regulatory subunit 7 (NCU02840)
  • 26S protease regulatory subunit 7 (ANI_1_1748024)
  • 26S protease regulatory subunit 7 (BBOV_IV009940)
  • 26S protease regulatory subunit 7 (GL50803_86683)
  • 26S protease regulatory subunit 7 (GL50803_21331)
  • 26S protease regulatory subunit 7 (AOR_1_728084)
  • 26S protease regulatory subunit 7 (EHI_080890)
  • 26S protease regulatory subunit 7 (UREG_01412)
  • 26S protease regulatory subunit 7 (psmC2)
  • 26S protease regulatory subunit 7 (PITG_10169)
  • 26S protease regulatory subunit 7 (MGYG_05184)
  • 26S protease regulatory subunit 7 (CGB_G1530W)
  • 26S protease regulatory subunit 7 (Tsp_09237)
  • proteasome (prosome, macropain) 26S subunit, ATPase, 2 (PSMC2)
  • 26S protease regulatory subunit 7 (psmc2)
  • GTP binding protein 3 (mitochondrial) (GTPBP3)
  • proteasome (prosome, macropain) 26S subunit, ATPase 2 (psmc2)
  • proteasome (prosome, macropain) 26S subunit, ATPase 2 (Psmc2)
  • proteasome (prosome, macropain) 26S subunit, ATPase, 2 (psmc2)
  • 23.m06337 protein
  • An02g12760 protein
  • AO090020000414 protein
  • DDBDRAFT_0168337 protein
  • DDBDRAFT_0232966 protein
  • DDB_0168337 protein
  • DDB_0232966 protein
  • GTPBG3 protein
  • MSS1 protein
  • MTGP1 protein
  • Nbla10058 protein
  • NCU02840.1 protein
  • psmc2 protein
  • S7 protein
  • THDF1 protein
  • xMSS1 protein
  • zgc:63995 protein

Protein level used designations for PSMC2

26S protease regulatory subunit 7 , 26S proteasome ATPase 2 subunit , 26S proteasome AAA-ATPase subunit RPT1 , proteasome 26S subunit ATPase 2 , mitochondrial GTP-binding protein 1 , tRNA modification GTPase GTPBP3, mitochondrial , mammalian suppressor of sgv-1 of yeast , protease 26S subunit 7 , proteasome 26S subunit, ATPase, 2 , putative protein product of Nbla10058 , proteasome (prosome, macropain) 26S subunit, ATPase 2

GENE ID SPECIES
3880279 Neurospora crassa OR74A
4979816 Aspergillus niger CBS 513.88
5479150 Babesia bovis T2Bo
5700344 Giardia lamblia ATCC 50803
5701262 Giardia lamblia ATCC 50803
5996822 Aspergillus oryzae RIB40
6220187 Entamoeba histolytica HM-1:IMSS
8440666 Uncinocarpus reesii 1704
8620693 Dictyostelium discoideum AX4
9461342 Phytophthora infestans T30-4
10027865 Arthroderma gypseum CBS 118893
10188938 Cryptococcus gattii WM276
10905033 Trichinella spiralis
100173102 Pongo abelii
100194555 Salmo salar
84705 Homo sapiens
393941 Danio rerio
19181 Mus musculus
25581 Rattus norvegicus
5701 Homo sapiens
399327 Xenopus laevis
417716 Gallus gallus
475896 Canis lupus familiaris
530186 Bos taurus
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