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anti-Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8) Antibodies

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. Additionally we are shipping Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) Proteins (14) and Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PSMB8 16913 P28063
PSMB8 5696 P28062
PSMB8 24968 P28064
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Top anti-Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) Antibodies at antibodies-online.com

Showing 10 out of 80 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Goat Un-conjugated EIA, WB Anti-LMP7 (0.01µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Mouse Un-conjugated ICC, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Immunofluorescence analysis of Hela cells using PSMB8 mouse mAb (green) . Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. 100 μL Log in to see 3 to 4 Days
$430.10
Details
Human Mouse Un-conjugated IF Immunofluorescence of monoclonal antibody to PSMB8 on HeLa cell (antibody concentration 10 µg/mL). Immunoperoxidase of monoclonal antibody to PSMB8 on formalin-fixed paraffin-embedded human colon (antibody concentration 3 µg/mL). 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated FACS, WB PSMB8 Antibody (N-term) (ABIN658498) western blot analysis in HL-60 cell line lysates (35 µg/lane). This demonstrates the PSMB8 antibody detected the PSMB8 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Mouse Un-conjugated EIA, IF, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$423.50
Details
Human Mouse Un-conjugated IF, IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to PSMB8 on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml] Immunofluorescence of monoclonal antibody to PSMB8 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated ICC, IF, IHC, ELISA, WB 100 μL Log in to see 8 to 10 Days
$551.83
Details
Human Goat Un-conjugated IHC (p), ELISA, WB Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit Un-conjugated ICC, IHC (p), WB   100 μL Log in to see 8 to 10 Days
$507.83
Details

PSMB8 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) Antibodies

  1. Human Monoclonal PSMB8 Primary Antibody for EIA, IF - ABIN1108774 : Mehta, Jordanova, Corver, van Wezel, Uh, Kenter, Jan Fleuren: Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma. in Genes, chromosomes & cancer 2009 (PubMed)
    Show all 2 references for ABIN1108774

  2. Human Monoclonal PSMB8 Primary Antibody for ICC, IHC - ABIN969371 : Camarena, Aquino-Galvez, Falfán-Valencia, Sánchez, Montaño, Ramos, Juárez, García-de-Alba, Granados, Selman: PSMB8 (LMP7) but not PSMB9 (LMP2) gene polymorphisms are associated to pigeon breeder's hypersensitivity pneumonitis. in Respiratory medicine 2010 (PubMed)
    Show all 2 references for ABIN969371

  3. Cow (Bovine) Polyclonal PSMB8 Primary Antibody for EIA, WB - ABIN615902 : Deshpande, Wheeler, Hunt, Peyton, White, Valdez, Nolan: Variation in HLA class I antigen-processing genes and susceptibility to human papillomavirus type 16-associated cervical cancer. in The Journal of infectious diseases 2008 (PubMed)

  4. Human Monoclonal PSMB8 Primary Antibody for IF - ABIN393460 : Hamamura, Chen, Nishimura, Tanjung, Sudo, Yokota: Predicting and validating the pathway of Wnt3a-driven suppression of osteoclastogenesis. in Cellular signalling 2014 (PubMed)

  5. Human Monoclonal PSMB8 Primary Antibody for IF, IHC (p) - ABIN562483 : Nijholt, de Graaf, van Haastert, Oliveira, Berkers, Zwart, Ovaa, Baas, Hoozemans, Scheper: Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease. in Cell death and differentiation 2011 (PubMed)

More Antibodies against Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) Interaction Partners

Mouse (Murine) Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8) interaction partners

  1. LMP7 deficiency decreased inflammatory responses such as macrophage infiltration and chemokine (show CCL1 Antibodies) expression while it increased serum adiponection levels.

  2. these data support that LMP7 inhibition in the context of BMT modulates allogeneic responses by decreasing endogenous miHA (show XIAP Antibodies) presentation and that the consequential reduction in allogeneic stimulation and cytokine production reduces GVHD development.

  3. PSMB8, ALDH1A1 (show ALDH1A1 Antibodies), and HSPA4 (show HSPA4 Antibodies) were identified to be located in ovarian tissues, to regulate 12 cellular pathways, and demonstrate age-dependent dynamic changes in expression profiling.

  4. Overexpression of the immunoproteasome LMP7 subunit in antigen-presenting cells due to lipopolysaccharide exposure as well as LMP7 expression in peripheral cells, are required for CD8 (show CD8A Antibodies)+ T-cell auto-reactivity.

  5. Data show that knockdown of i-proteasome catalytic subunit PSMB9 (show PSMB9 Antibodies) by short hairpin RNA (shRNA) decreased the expression of both PSMB9 (show PSMB9 Antibodies) and PSMB8 without affecting other catalytic subunits of the proteasome.

  6. we present novel evidence for the requirement of the beta5i immunosubunit to generate a strong Th2 response during OVA- but not HDM (show HDAC3 Antibodies)-induced acute asthma.

  7. Red blood cells of LMP7-deficient mice were more likely to deform in response to infection with malaria parasites, presumably resulting in higher susceptibility to phagocytosis and in the partial resistance to malaria.

  8. Deletion or inhibition of LMP7 suppresses generation of T helper (Th)17 cells but promotes regulatory T cell (Treg) development.

  9. Probeta5 predominantly promotes integration into LMP2 (show PSMB9 Antibodies)/MECL-1 (show PSMB10 Antibodies)-containing precursors in IFNgamma-stimulated, LMP7-deficient cells and infected LMP7-deficient mice.

  10. LMP7 and MECL1 (show PSMB10 Antibodies) regulate cytokine expression, suggesting this system represents a novel mechanism for the regulation of cytokines and cytokine signaling

Human Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8) interaction partners

  1. demonstrated that patients with the LMP-7 CA/AA genotypes were more likely to have advanced fibrosis scores than those bearing the CC genotype

  2. lupus nephritis showed up-regulation of the immunoproteasome subunit LMP7 in tubular epithelial cells associated with type I interferon (show IFNA Antibodies) signature.

  3. Comparison with reference profiles of sorted immune cells and healthy muscle confirmed upregulation of PSMB8 and -9 in myositis biopsies beyond infiltration related changes.

  4. The LMP7 gene promoter methylation and protein downregulation were correlated at high extent in Kazakh's ESCC patients, and may explain the epigenetic regulation on gene expression.

  5. In patients with primary Sjogren's syndrome, the expression of LMP7 (but not LMP2 (show PSMB9 Antibodies)) is up-regulated in the labial (show LAT2 Antibodies) gland.

  6. Data indicate that treatment-emergent resistance to single-agent bortezomib was independent of variants in the proteasome genes PSMB1 (show PSMB1 Antibodies), PSMB5 (show PSMB5 Antibodies), PSMB6 (show PSMB6 Antibodies), PSMB8, PSMB9 (show PSMB9 Antibodies), and PSMB10 (show PSMB10 Antibodies).

  7. The MAGE (show MAGEB10 Antibodies)-C(2336-344) antigenic peptide is produced by the immunoproteasome and intermediate proteasome beta1i (show PSMB9 Antibodies)-beta5i, but not by the standard proteasome nor intermediate proteasome beta5i.

  8. high risk of colon cancer was associated with LMP7-K/Q genotype and low risk with LMP7-Q/Q genotype; results suggest the presence of LMP7-K can reduce formation of immunoproteasomes and thus peptide processing, followed by reduced peptide-HLA presentation, a crucial factor in the immune response against cancer

  9. CANDLE syndrome is caused by mutations in PSMB8, a gene recently reported to cause "JMP" syndrome in adults.

  10. the genetic variant within the LMP2 (show PSMB9 Antibodies)/LMP7 gene would increase the risk of intestinal M. tuberculosis infection.

Pig (Porcine) Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8) interaction partners

  1. These results suggest LMP2 (show PSMB9 Antibodies)/LMP7 gene should be regarded as molecular marker to estimate animal's immune status for their effects on hematological traits.

Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8) Antigen Profile

Protein Summary

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified\; both isoforms are processed to yield the same mature subunit.

Gene names and symbols associated with PSMB8

  • proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) (Psmb8) antibody
  • proteasome (prosome, macropain) subunit, beta type, 8 (PSMB8) antibody
  • proteasome (prosome, macropain) subunit, beta type, 8 (Psmb8) antibody
  • proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) (PSMB8) antibody
  • ALDD antibody
  • ATP6V0D2 antibody
  • D6S216 antibody
  • D6S216E antibody
  • JMP antibody
  • Lmp-7 antibody
  • LMP7 antibody
  • NKJO antibody
  • PSMB5i antibody
  • Ring10 antibody

Protein level used designations for PSMB8

MC13 (LMP7) , large multifunctional protease 7 , low molecular mass protein 7 , macropain subunit C13 , multicatalytic endopeptidase complex subunit C13 , proteasome component C13 , proteasome subunit MC13 , proteasome subunit beta type-8 , proteasome subunit beta-5i , proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) , proteosome beta 8 subunit , large multifunctional peptidase 7 , low molecular weight protein 7 , protease component C13 , proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) , proteasome catalytic subunit 3i , proteasome subunit Y2 , proteasome subunit beta 5i , proteasome-related gene 7 , really interesting new gene 10 protein , low molecular mass polypeptide 7 , proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) , MHC class II DO beta , proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7) , proteasome beta 8 subunit , proteasome subunit LMP7 , macropain , proteasome subunit, beta type 8

GENE ID SPECIES
16913 Mus musculus
5696 Homo sapiens
24968 Rattus norvegicus
474865 Canis lupus familiaris
396975 Sus scrofa
282013 Bos taurus
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