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Protein AF-10 Proteins (MLLT10)

MLLT10 encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Additionally we are shipping MLLT10 Antibodies (112) and MLLT10 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MLLT10 8028 P55197
MLLT10 17354 O54826
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Top MLLT10 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

MLLT10 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Protein AF-10 (MLLT10) Interaction Partners

Human Protein AF-10 (MLLT10) interaction partners

  1. The PZP (show PZP Proteins) domain of AF10 senses unmodified H3K27 to regulate DOT1L (show DOT1L Proteins)-mediated methylation of H3K79.

  2. we report that variants at the MLLT10 locus are unlikely to alter risk of glioma, and they have no prognostic value among patients with high-grade tumors (glioblastoma).

  3. Results provide evidence that transformation driven by MLL (show MLL Proteins) fusions as well as the recurrent AML (show RUNX1 Proteins)-associated NUP98 (show NUP98 Proteins)-NSD1 fusion oncogene (show RAB1A Proteins) is critically dependent on the ability of AF10 to stimulate DOT1L (show DOT1L Proteins) activity.

  4. detection of PICALM (show PICALM Proteins)-MLLT10 fusion transcript occurs in 7% of children with T-lineage ALL and is not associated with a poorer outcome for patients treated with contemporary, intensive chemotherapy

  5. In pediatric T-acute lymphoblastic leukemia, we have identified 2 RNA processing genes, that is, HNRNPH1 (show HNRNPH1 Proteins)/5q35 and DDX3X (show DDX3X Proteins)/Xp11.3 as new MLLT10 fusion partners.

  6. results strongly indicate that the differential regulation of these three genes is not due to the break point effect but as a consequence of the CALM/AF10 fusion gene expression, though the mechanism of regulation is not well understood

  7. In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin

  8. a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 x 10(-14)) was identified.

  9. FISH analysis in infant AML (show RUNX1 Proteins)-M5 showed a complex rearrangement between chromosomes 10 and 11, disrupting the MLL (show MLL Proteins) gene, a paracentric inversion of the 11q13-q23 fragment translocated to 10p12. AF10 was the fusion partner gene of MLL (show MLL Proteins) in this rearrangement.

  10. ALL1 (show MLL Proteins) is involved in remodeling, acetylating, deacetylating, and methylating nucleosomes and/or free histones

Mouse (Murine) Protein AF-10 (MLLT10) interaction partners

  1. Results provide evidence that transformation driven by MLL (show MLL Proteins) fusions as well as the recurrent AML (show RUNX1 Proteins)-associated NUP98 (show NUP98 Proteins)-NSD1 fusion oncogene (show RAB1A Proteins) is critically dependent on the ability of AF10 to stimulate DOT1L (show DOT1L Proteins) activity.

  2. During leukemogenesis, CALM-AF10 plays critical roles in the cytoplasm.

  3. In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin

  4. further suggest that future approaches to antagonize CALM-AF10-induced transformation should incorporate strategies, which aim at blocking these key domains

  5. conclude that Mllt10/Af10-Dot1l (show DOT1L Proteins) are essential, largely dedicated activators of Wnt (show WNT2 Proteins)-dependent transcription, critical for maintenance of intestinal proliferation and homeostasis

MLLT10 Protein Profile

Protein Summary

This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Protein AF-10 Proteins (MLLT10)

  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 (MLLT10)
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 (Mllt10)
  • Af10 protein
  • B130021D15Rik protein
  • D630001B22Rik protein
  • mKIAA4140 protein

Protein level used designations for Protein AF-10 Proteins (MLLT10)

ALL1-fused gene from chromosome 10 protein , protein AF-10 , type I AF10 protein , type III AF10 protein , type IV AF10 protein , myeloid/lymphoid or mixed lineage-leukemia translocation to 10 homolog

GENE ID SPECIES
8028 Homo sapiens
17354 Mus musculus
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