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PRMT1 encodes a member of the protein arginine N-methyltransferase (PRMT) family. Additionally we are shipping PRMT1 Antibodies (142) and PRMT1 Proteins (36) and many more products for this protein.
Our data suggest that miR (show MLXIP ELISA Kits)-19a and PRMT1 might be novel indicators of asthma and present new disease-specific therapeutic targets to reduce airway wall remodeling and inflammation in asthmatic patients
The PRMT1 active site residues, Met48 and His293, have been determined to play a key role in dictating product specificity, as: (1) the single mutation of Met48 to Phe enabled PRMT1 to generate MMA (show MMD ELISA Kits), ADMA, and a limited amount of SDMA; (2) the single mutation of His293 to Ser (show SIGLEC1 ELISA Kits) formed the expected MMA (show MMD ELISA Kits) and ADMA products only; (3) the double mutant H293S-M48F-PRMT1 produced SMDA as the major product with limit amount of SDMA.
This article reviews the current literature from research showing interdependent association between cav1 (show CAV1 ELISA Kits)-PRMT1-SIRT1 (show SIRT1 ELISA Kits) to the outcomes of experimental and clinical research aiming to preserve endothelial function with gene- or pharmaco-therapy. [review]
Increase in HLAB expression was concomitant with increase in HIF-1alpha (show HIF1A ELISA Kits) and decrease in PRMT1 levels.
Low expression of PRMT1 is associated with low chemosensitivity in gastric cancer.
PRMT1 is overexpressed in human melanoma, and may regulate tumor growth and metastasis via targeting ALCAM (show ALCAM ELISA Kits).
Protein arginine N-methyltransferase 1 expression was found to be significantly upregulated in hepatocellular carcinoma cell lines and clinical tissues.
FAM98A, whose physiological function is unknown, was arginine-methylated by PRMT1.
PRMT1 promoted the methylation of Gli1 (show GLI1 ELISA Kits).
The oncogenic roles of PRMT1 in the progression of ESCC.
prmt8 (show PRMT8 ELISA Kits) may play important roles non-overlapping with prmt1 in embryonic and neural development depending on its specific N-terminus.
prmt1 gene is actively and ubiquitously expressed at both RNA and protein levels at the early developmental stages of zebrafish.
PRMT1 functions transiently as a coactivator in thyroid hormone (show PTH ELISA Kits) (T3) receptor (TR)-mediated transcription by enhancing TR-T3 response element binding and further suggest that PRMT1 has tissue-specific roles in regulating the rate of metamorphosis.
Results suggest that part of the type I arginine methyltransferases in brains, mainly PRMT1, are sequestered in an inactive form as they associated with membranes or large subcellular complexes.
Collectively, the authors propose that Prmt1-dependent facilitation of KCNQ (show KCNQ1 ELISA Kits)-phosphatidylinositol-4,5-bisphosphate interaction underlies the positive regulation of KCNQ (show KCNQ1 ELISA Kits) activity by arginine methylation, which may serve as a key target for prevention of neuronal hyperexcitability and seizures.
Results identify a key molecular mechanism by which the BTG2 (show BTG2 ELISA Kits)-PRMT1 module regulates pre-B cell differentiation and inhibits pre-B cell leukemogenesis.
Data, including data from studies in cells from knockout mice, suggest that Prmt1 activity was necessary for c-Myc (show MYC ELISA Kits) binding to acetyltransferase p300 (show NOTCH1 ELISA Kits) in myeloid cells; Prmt1 inhibition decreases p300 (show NOTCH1 ELISA Kits) recruitment to c-Myc (show MYC ELISA Kits) target promoters and increased Hdac1 (show HDAC1 ELISA Kits) recruitment. [Prmt1, protein arginine N-methyltransferase 1; c-Myc (show MYC ELISA Kits) = Proto-Oncogene (show RAB1A ELISA Kits) Proteins c-myc (show MYC ELISA Kits); Hdac1 (show HDAC1 ELISA Kits) = histone deacetylase 1 (show HDAC1 ELISA Kits)]
PRMT1-dependent regulation of macrophage PPARgamma (show PPARG ELISA Kits) expression contributes to the infection susceptibility in PRMT1 knock-out mice
These findings suggest that arginine methylation by PRMT1 regulates muscle stem cell fate through the Eya1 (show EYA1 ELISA Kits)/Six1 (show SIX1 ELISA Kits)/MyoD (show MYOD1 ELISA Kits) axis.
PRMT1 is necessary for lymphocyte functions in vivo.
The Protein arginine methyltransferase 1 (PRMT1) is involved in multiple cellular functions including proliferation and differentiation and PRMT1 is important for embryonic vascular formation.
A time-dependent decrease in serum and tissue ADMA and increase in mRNA expression of DDAH-1 and PRMT-1 as well as higher rates of mRNA expression of CAT-1 and lower rates of CAT-2A and CAT-2B were found after 8-week MCD diet.
PRMT1 is required for CNS development, especially for oligodendrocyte maturation processes
Pharmacological inhibition of KDM4C (show KDM4C ELISA Kits)/PRMT1 suppresses transcription and transformation ability of MLL (show MLL ELISA Kits) fusions
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5.
protein arginine N-methyltransferase 1
, protein arginine methyltransferase 1
, protein arginine N-methyltransferase
, HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2
, heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2
, histone-arginine N-methyltransferase PRMT1
, interferon receptor 1-bound protein 4
, HMT1 hnRNP methyltransferase-like 2
, histone-arginine N-methyltransferase PRMT1-A
, protein arginine N-methyltransferase 1-A
, heterogeneous nuclear ribonucleoproteins methyltransferase-like 2
, arginine N-methyltransferase 1