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PRMT1 encodes a member of the protein arginine N-methyltransferase (PRMT) family. Additionally we are shipping PRMT1 Antibodies (142) and many more products for this protein.
Showing 10 out of 36 products:
Human PRMT1 Protein expressed in HEK-293 Cells - ABIN2729657
Tikhanovich, Kuravi, Artigues, Villar, Dorko, Nawabi, Roberts, Weinman: Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling. in The Journal of biological chemistry 2015
RALY (show RALY Proteins) promotes Protein Arginine Methyltransferase 1 alternatively spliced isoform v2 relative expression and metastatic potential in breast cancer cells
the two structural homologs FAM98A and FAM98B included in a novel complex with DDX1 (show DDX1 Proteins) and C14orf166 (show C14orf166 Proteins) are required for PRMT1 expression in colorectal cancer cell lines
Maintenance of the progenitors thus requires cooperation by PRMT1 and CSNK1a1 (show CSNK1A1 Proteins) to sustain proliferation gene expression and suppress premature differentiation driven by GRHL3 (show GRHL3 Proteins)
PRMT1 methylates Nrf2 (show GABPA Proteins) protein at a single residue of arginine 437, both in vitro and in vivo. This leads to a moderate increase of its DNA-binding activity and transactivation, which subsequently protects cells against the tBHP-induced glutathione depletion and cell death.
Our data suggest that miR (show MLXIP Proteins)-19a and PRMT1 might be novel indicators of asthma and present new disease-specific therapeutic targets to reduce airway wall remodeling and inflammation in asthmatic patients
The PRMT1 active site residues, Met48 and His293, have been determined to play a key role in dictating product specificity, as: (1) the single mutation of Met48 to Phe enabled PRMT1 to generate MMA (show MMD Proteins), ADMA, and a limited amount of SDMA; (2) the single mutation of His293 to Ser (show SIGLEC1 Proteins) formed the expected MMA (show MMD Proteins) and ADMA products only; (3) the double mutant H293S-M48F-PRMT1 produced SMDA as the major product with limit amount of SDMA.
This article reviews the current literature from research showing interdependent association between cav1 (show CAV1 Proteins)-PRMT1-SIRT1 (show SIRT1 Proteins) to the outcomes of experimental and clinical research aiming to preserve endothelial function with gene- or pharmaco-therapy. [review]
Increase in HLAB expression was concomitant with increase in HIF-1alpha (show HIF1A Proteins) and decrease in PRMT1 levels.
Low expression of PRMT1 is associated with low chemosensitivity in gastric cancer.
PRMT1 is overexpressed in human melanoma, and may regulate tumor growth and metastasis via targeting ALCAM (show ALCAM Proteins).
prmt8 (show PRMT8 Proteins) may play important roles non-overlapping with prmt1 in embryonic and neural development depending on its specific N-terminus.
prmt1 gene is actively and ubiquitously expressed at both RNA and protein levels at the early developmental stages of zebrafish.
PRMT1 functions transiently as a coactivator in thyroid hormone (show PTH Proteins) (T3) receptor (TR)-mediated transcription by enhancing TR-T3 response element binding and further suggest that PRMT1 has tissue-specific roles in regulating the rate of metamorphosis.
Results suggest that part of the type I arginine methyltransferases in brains, mainly PRMT1, are sequestered in an inactive form as they associated with membranes or large subcellular complexes.
Low Prmt1 expression is associated with osteosarcoma.
Collectively, the authors propose that Prmt1-dependent facilitation of KCNQ (show KCNQ1 Proteins)-phosphatidylinositol-4,5-bisphosphate interaction underlies the positive regulation of KCNQ (show KCNQ1 Proteins) activity by arginine methylation, which may serve as a key target for prevention of neuronal hyperexcitability and seizures.
Results identify a key molecular mechanism by which the BTG2 (show BTG2 Proteins)-PRMT1 module regulates pre-B cell differentiation and inhibits pre-B cell leukemogenesis.
Data, including data from studies in cells from knockout mice, suggest that Prmt1 activity was necessary for c-Myc (show MYC Proteins) binding to acetyltransferase p300 (show NOTCH1 Proteins) in myeloid cells; Prmt1 inhibition decreases p300 (show NOTCH1 Proteins) recruitment to c-Myc (show MYC Proteins) target promoters and increased Hdac1 (show HDAC1 Proteins) recruitment. [Prmt1, protein arginine N-methyltransferase 1; c-Myc (show MYC Proteins) = Proto-Oncogene (show RAB1A Proteins) Proteins c-myc (show MYC Proteins); Hdac1 (show HDAC1 Proteins) = histone deacetylase 1 (show HDAC1 Proteins)]
PRMT1-dependent regulation of macrophage PPARgamma (show PPARG Proteins) expression contributes to the infection susceptibility in PRMT1 knock-out mice
These findings suggest that arginine methylation by PRMT1 regulates muscle stem cell fate through the Eya1 (show EYA1 Proteins)/Six1 (show SIX1 Proteins)/MyoD (show MYOD1 Proteins) axis.
PRMT1 is necessary for lymphocyte functions in vivo.
The Protein arginine methyltransferase 1 (PRMT1) is involved in multiple cellular functions including proliferation and differentiation and PRMT1 is important for embryonic vascular formation.
A time-dependent decrease in serum and tissue ADMA and increase in mRNA expression of DDAH-1 and PRMT-1 as well as higher rates of mRNA expression of CAT-1 and lower rates of CAT-2A and CAT-2B were found after 8-week MCD diet.
PRMT1 is required for CNS development, especially for oligodendrocyte maturation processes
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5.
protein arginine N-methyltransferase 1
, protein arginine methyltransferase 1
, protein arginine N-methyltransferase
, HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2
, heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2
, histone-arginine N-methyltransferase PRMT1
, interferon receptor 1-bound protein 4
, HMT1 hnRNP methyltransferase-like 2
, histone-arginine N-methyltransferase PRMT1-A
, protein arginine N-methyltransferase 1-A
, heterogeneous nuclear ribonucleoproteins methyltransferase-like 2
, arginine N-methyltransferase 1