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Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Additionally we are shipping PRMT5 Proteins (8) and many more products for this protein.
Showing 10 out of 138 products:
Human Polyclonal PRMT5 Primary Antibody for EIA, IHC (p) - ABIN356529
Pal, Yun, Datta, Lacomis, Erdjument-Bromage, Kumar, Tempst, Sif: mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad. in Molecular and cellular biology 2003
Show all 4 references for ABIN356529
Human Polyclonal PRMT5 Primary Antibody for EIA, WB - ABIN356527
Rho, Choi, Seong, Cho, Kim, Im: Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family. in The Journal of biological chemistry 2001
Show all 4 references for ABIN356527
Dog (Canine) Monoclonal PRMT5 Primary Antibody for IF, WB - ABIN968581
Gilbreth, Yang, Bartholomeusz, Pimental, Kansra, Gadiraju, Marcus: Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs. in Proceedings of the National Academy of Sciences of the United States of America 1999
Show all 3 references for ABIN968581
Cow (Bovine) Polyclonal PRMT5 Primary Antibody for EIA, WB - ABIN401522
Zhao, Rank, Tan, Li, Moritz, Simpson, Cerruti, Curtis, Patel, Allis, Cunningham, Jane: PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. in Nature structural & molecular biology 2009
Chicken Polyclonal PRMT5 Primary Antibody for IHC, WB - ABIN2778654
Azzouz, Pillai, Däpp, Chari, Meister, Kambach, Fischer, Schümperli: Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes. in The Journal of biological chemistry 2005
Increased PRMT5 activity enhanced acute myeloid leukemia (show BCL11A Antibodies) growth.
arginine residues within the third intracellular loop of the D2 dopamine receptor were methylated by protein arginine methyltransferase 5 (PRMT5)
high nuclear expression of Protein arginine methyltransferase-5 is a potentially useful marker for estimating submucosal invasion of early colorectal carcinomas in endoscopically resected specimens
Findings provide new evidence that PRMT5 plays an important role in CRC (show CALR Antibodies) pathogenesis through epigenetically regulating arginine methylation of oncogenes such as eIF4E (show EIF4E Antibodies) and FGFR3 (show FGFR3 Antibodies).
PRMT5-induced methylation prevented phosphorylation of SREBP1a on S430 by GSK3beta (show GSK3b Antibodies)
PRMT5 plays an important role in human hepatocellular carcinoma growth via the downregulation of beta-catenin (show CTNNB1 Antibodies)
Data show that the E3 ubiquitin ligase (show MUL1 Antibodies) CHIP interacts with protein arginine methyltransferase-5 (PRMT5) both in vivo and in vitro.
PRMT5 gene is silencing gene expression by histone arginine methylation in keratinocytes.
PRMT5 co-localizes with RASSF1A (show RASSF1 Antibodies) on stabilized microtubules.RASSF1A promotes the translocation of cytosolic PRMT5 to microtubules.
UHRF1 (show UHRF1 Antibodies) could form a complex with PRMT5 to contribute to the endometrial carcinogenesis.
a combinatorial role of PRMT4/CARM1 (show CARM1 Antibodies) and PRMT5 for proper myogenesis in zebrafish
Data indicate that MEP50 (show WDR77 Antibodies) WD repeat protein (show DCAF7 Antibodies) is essential for methylation of histones H4 and H2A (show H2AFX Antibodies) by PRMT5 arginine methyltransferase.
data support a mechanism in which MEP50 (show WDR77 Antibodies) binds substrate and stimulates PRMT5 activity modulated by substrate post-translational modifications
Protein arginine methyltransferase Prmt5-Mep50 (show WDR77 Antibodies) methylates histones H2A (show H2AFX Antibodies) and H4 and the histone chaperone nucleoplasmin (show NPM1 Antibodies) in Xenopus laevis eggs
Taken together, our data reveal a pathophysiologically relevant role for PRMT5 in MHC II transactivation in macrophages
Prmt5 is required for germ cell survival during spermatogenesis in mice.
Prmt5 controls proliferation of adult muscle stem cells by direct epigenetic silencing of the cell cycle inhibitor (show CDKN2A Antibodies) p21 (show D4S234E Antibodies).
Prmt5 plays critical roles in germ cell development that are required for germ cell survival during embryonic stages
results demonstrate that PRMT5 plays distinct roles in the behavior of HSCs compared with HPCs and is essential for the maintenance of adult hematopoietic cells.
PRMT5 regulates gene expression by promoting methylation of the Sm spliceosomal proteins, but is not required for primordial germ cell specification.
PRMT5 controls symmetrical dimethylation on arginine-3 of histone H4 in mouse embryonic fibroblasts.
PRMT5 knockdown in non-Hodgkin lymphoma cell lines and primary lymphoma cells leads to RBL2 (show RBL2 Antibodies) derepression and RB1 (show RB1 Antibodies) reactivation, which in turn inhibit PRC2 expression.
PRMT5 is a master regulator of splicing in mammals
type II protein arginine methyltransferase 5 has a role in the regulation of Circadian Per1 (show PER1 Antibodies) and CRY1 (show CRY1 Antibodies) genes
Analysis of prmt-5-deficient worms indicated that methylation promoted the dopamine-mediated modulation of chemosensory and locomotory behaviors through the DOP (show COPB2 Antibodies)-3 receptor.
data confirm that MEP50 (show WDR77 Antibodies) plays a key role in substrate recognition and activates PRMT5 activity by increasing its affinity for protein substrates.
the substrate specificity, processivity, and kinetic mechanism of bacterially expressed Caenorhabditis elegans PRMT5 (cPRMT5).
analysis of structural insights into protein arginine symmetric dimethylation by PRMT5
PRMT-5 represses CEP-1 transcriptional activity through CBP-1, which represents a novel regulatory mechanism of p53 (show TP53 Antibodies)-dependent apoptosis.
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3)\; such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR\; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (By similarity). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (By similarity). Methylates HOXA9 (By similarity).
protein arginine methyltransferase 5
, protein arginine N-methyltransferase 5
, SKB1 homolog
, shk1 kinase-binding protein 1 homolog
, histone-arginine N-methyltransferase PRMT5
, putative arginine N-methyltransferase, type II
, protein arginine methyltransferase
, protein arginine N-methyltransferase 5-like
, 72 kDa ICln-binding protein
, HMT1 hnRNP methyltransferase-like 5
, jak-binding protein 1
, Jak-binding protein 1