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anti-Protein Arginine Methyltransferase 5 (PRMT5) Antibodies

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Additionally we are shipping PRMT5 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PRMT5 445443  
PRMT5 10419 O14744
PRMT5 27374 Q8CIG8
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Top anti-PRMT5 Antibodies at antibodies-online.com

Showing 10 out of 147 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-PRMT5 Antibody Titration: 2.5ug/mlELISA Titer: 1:62500Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Cow Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Dog Mouse Un-conjugated IF, WB Western blot analysis of JBP1/SKB1HS on SW13 lysate. Lane 1: 1:500), lane 2: 1:1000, lane 3: 1:2000 of JBP1/SKB1HS. PC12 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-PRMT5 Antibody (C-term C487) (ABIN387841) in HL60 cell line lysates (35 µg/lane).PRMT5(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB PRMT5 Antibody (N-term) (ABIN657695) western blot analysis in HL-60 cell line lysates (35 µg/lane). This demonstrates the PRMT5 antibody detected the PRMT5 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated IHC (p), IP, WB 50 μL Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-PRMT5 Pab (ABIN387843) is used in Western blot to detect PRMT5 in HL60 cell lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details

PRMT5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-PRMT5 Antibodies

  1. Human Polyclonal PRMT5 Primary Antibody for EIA, WB - ABIN356527 : Pal, Yun, Datta, Lacomis, Erdjument-Bromage, Kumar, Tempst, Sif: mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad. in Molecular and cellular biology 2003 (PubMed)
    Show all 4 references for ABIN356527

  2. Human Polyclonal PRMT5 Primary Antibody for EIA, IHC (p) - ABIN356529 : Rho, Choi, Seong, Cho, Kim, Im: Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family. in The Journal of biological chemistry 2001 (PubMed)
    Show all 4 references for ABIN356529

  3. Dog (Canine) Monoclonal PRMT5 Primary Antibody for IF, WB - ABIN968581 : Gilbreth, Yang, Bartholomeusz, Pimental, Kansra, Gadiraju, Marcus: Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs. in Proceedings of the National Academy of Sciences of the United States of America 1999 (PubMed)
    Show all 3 references for ABIN968581

  4. Cow (Bovine) Polyclonal PRMT5 Primary Antibody for EIA, WB - ABIN401522 : Zhao, Rank, Tan, Li, Moritz, Simpson, Cerruti, Curtis, Patel, Allis, Cunningham, Jane: PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. in Nature structural & molecular biology 2009 (PubMed)

  5. Chicken Polyclonal PRMT5 Primary Antibody for IHC, WB - ABIN2778654 : Azzouz, Pillai, Däpp, Chari, Meister, Kambach, Fischer, Schümperli: Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes. in The Journal of biological chemistry 2005 (PubMed)

More Antibodies against PRMT5 Interaction Partners

Human Protein Arginine Methyltransferase 5 (PRMT5) interaction partners

  1. Our results indicate that PRMT5 is a marker of poor prognosis in NPC (show NPC1 Antibodies) patients. PRMT5 promoted the radioresistance of NPC (show NPC1 Antibodies) cells via targeting FGFR3 (show FGFR3 Antibodies), at least partly if not totally.

  2. Data show that Omomyc protein co-localized with proto-oncogene (show RAB1A Antibodies) protein c (show PROC Antibodies)-myc (c-Myc (show MYC Antibodies)), protein arginine methyltransferase 5 (PRMT5) and histone H4 H4R3me2s-enriched chromatin domains.

  3. PRMT5 expression was upregulated during HTLV-1-mediated T-cell transformation.

  4. Increased PRMT5 activity enhanced acute myeloid leukemia (show BCL11A Antibodies) growth.

  5. arginine residues within the third intracellular loop of the D2 dopamine receptor were methylated by protein arginine methyltransferase 5 (PRMT5)

  6. high nuclear expression of Protein arginine methyltransferase-5 is a potentially useful marker for estimating submucosal invasion of early colorectal carcinomas in endoscopically resected specimens

  7. Findings provide new evidence that PRMT5 plays an important role in CRC (show CALR Antibodies) pathogenesis through epigenetically regulating arginine methylation of oncogenes such as eIF4E (show EIF4E Antibodies) and FGFR3 (show FGFR3 Antibodies).

  8. PRMT5-induced methylation prevented phosphorylation of SREBP1a on S430 by GSK3beta (show GSK3b Antibodies)

  9. PRMT5 plays an important role in human hepatocellular carcinoma growth via the downregulation of beta-catenin (show CTNNB1 Antibodies)

  10. Data show that the E3 ubiquitin ligase (show MUL1 Antibodies) CHIP interacts with protein arginine methyltransferase-5 (PRMT5) both in vivo and in vitro.

Zebrafish Protein Arginine Methyltransferase 5 (PRMT5) interaction partners

  1. a combinatorial role of PRMT4/CARM1 (show CARM1 Antibodies) and PRMT5 for proper myogenesis in zebrafish

Xenopus laevis Protein Arginine Methyltransferase 5 (PRMT5) interaction partners

  1. Data indicate that MEP50 (show WDR77 Antibodies) WD repeat protein (show DCAF7 Antibodies) is essential for methylation of histones H4 and H2A (show H2AFX Antibodies) by PRMT5 arginine methyltransferase.

  2. data support a mechanism in which MEP50 (show WDR77 Antibodies) binds substrate and stimulates PRMT5 activity modulated by substrate post-translational modifications

  3. Protein arginine methyltransferase Prmt5-Mep50 (show WDR77 Antibodies) methylates histones H2A (show H2AFX Antibodies) and H4 and the histone chaperone nucleoplasmin (show NPM1 Antibodies) in Xenopus laevis eggs

Mouse (Murine) Protein Arginine Methyltransferase 5 (PRMT5) interaction partners

  1. Taken together, our data reveal a pathophysiologically relevant role for PRMT5 in MHC II transactivation in macrophages

  2. Prmt5 is required for germ cell survival during spermatogenesis in mice.

  3. Prmt5 controls proliferation of adult muscle stem cells by direct epigenetic silencing of the cell cycle inhibitor (show CDKN2A Antibodies) p21 (show D4S234E Antibodies).

  4. Prmt5 plays critical roles in germ cell development that are required for germ cell survival during embryonic stages

  5. results demonstrate that PRMT5 plays distinct roles in the behavior of HSCs compared with HPCs and is essential for the maintenance of adult hematopoietic cells.

  6. PRMT5 regulates gene expression by promoting methylation of the Sm spliceosomal proteins, but is not required for primordial germ cell specification.

  7. PRMT5 controls symmetrical dimethylation on arginine-3 of histone H4 in mouse embryonic fibroblasts.

  8. PRMT5 knockdown in non-Hodgkin lymphoma cell lines and primary lymphoma cells leads to RBL2 (show RBL2 Antibodies) derepression and RB1 (show RB1 Antibodies) reactivation, which in turn inhibit PRC2 expression.

  9. PRMT5 is a master regulator of splicing in mammals

  10. type II protein arginine methyltransferase 5 has a role in the regulation of Circadian Per1 (show PER1 Antibodies) and CRY1 (show CRY1 Antibodies) genes

Caenorhabditis elegans (C. elegans) Protein Arginine Methyltransferase 5 (PRMT5) interaction partners

  1. Analysis of prmt-5-deficient worms indicated that methylation promoted the dopamine-mediated modulation of chemosensory and locomotory behaviors through the DOP (show COPB2 Antibodies)-3 receptor.

  2. data confirm that MEP50 (show WDR77 Antibodies) plays a key role in substrate recognition and activates PRMT5 activity by increasing its affinity for protein substrates.

  3. the substrate specificity, processivity, and kinetic mechanism of bacterially expressed Caenorhabditis elegans PRMT5 (cPRMT5).

  4. analysis of structural insights into protein arginine symmetric dimethylation by PRMT5

  5. PRMT-5 represses CEP-1 transcriptional activity through CBP-1, which represents a novel regulatory mechanism of p53 (show TP53 Antibodies)-dependent apoptosis.

PRMT5 Antigen Profile

Protein Summary

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3)\; such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR\; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (By similarity). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (By similarity). Methylates HOXA9 (By similarity).

Gene names and symbols associated with PRMT5

  • protein arginine methyltransferase 5 (PRMT5) antibody
  • putative arginine N-methyltransferase, type II (PRMT5) antibody
  • Skb1 family protein (prmt5) antibody
  • protein arginine N-methyltransferase 5 (Prmt5) antibody
  • prmt5 protein (prmt5) antibody
  • protein arginine methyltransferase 5 (prmt5) antibody
  • HMT1 hnRNP methyltransferase-like 5 (S. cerevisiae) (Hrmt1l5) antibody
  • protein arginine methyltransferase 5 (Prmt5) antibody
  • Protein PRMT-5 (prmt-5) antibody
  • DDBDRAFT_0187422 antibody
  • DDBDRAFT_0235403 antibody
  • DDB_0187422 antibody
  • DDB_0235403 antibody
  • HRMT1L5 antibody
  • hsl7 antibody
  • IBP72 antibody
  • Jbp1 antibody
  • NV18830 antibody
  • Prmt5 antibody
  • si:zc14a17.2 antibody
  • Skb1 antibody
  • SKB1Hs antibody
  • wu:fb95f10 antibody
  • zgc:110669 antibody

Protein level used designations for PRMT5

protein arginine methyltransferase 5 , protein arginine N-methyltransferase 5 , SKB1 homolog , shk1 kinase-binding protein 1 homolog , histone-arginine N-methyltransferase PRMT5 , putative arginine N-methyltransferase, type II , protein arginine methyltransferase , protein arginine N-methyltransferase 5-like , 72 kDa ICln-binding protein , HMT1 hnRNP methyltransferase-like 5 , jak-binding protein 1 , Jak-binding protein 1

GENE ID SPECIES
100052729 Equus caballus
100583805 Nomascus leucogenys
100173581 Pongo abelii
452789 Pan troglodytes
712718 Macaca mulatta
5068851 Leishmania infantum JPCM5
8626071 Dictyostelium discoideum AX4
100024287 Monodelphis domestica
100115766 Nasonia vitripennis
100144380 Oryzias latipes
100145788 Xenopus (Silurana) tropicalis
100357415 Oryctolagus cuniculus
100473723 Ailuropoda melanoleuca
100555438 Anolis carolinensis
445443 Rattus norvegicus
10419 Homo sapiens
368664 Danio rerio
495515 Xenopus laevis
480242 Canis lupus familiaris
100294711 Sus scrofa
515594 Bos taurus
364382 Rattus norvegicus
27374 Mus musculus
175717 Caenorhabditis elegans
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